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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Cash flows from operating activities      
Net loss $ (170,521) $ (323,916) $ (514,706)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 17,516 24,896 33,112
Loss on abandonment and disposals of assets, net 4,442 3,071 20,928
Impairment of goodwill 9,635 87,862 0
Impairment of other noncurrent assets 13,326 32,627 60,504
Gain on sale of discontinued operations (672) 0 0
Loss on release of cumulative foreign currency translation adjustment 26,957 0 0
Reacquisition of in-process research and development 0 0 236,748
Loss on settlement agreement 11,436 0 0
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock, net 106 (7,833) 30,200
Noncash dividend income 0 (48) (14,841)
Amortization of discounts on investments, net (699) (1,005) (771)
Equity in net loss of affiliates 1,176 6,730 11,608
Stock-based compensation expense 18,366 18,950 36,296
Shares issued as payment for services 1,006 10,446 10,695
Provision for credit losses 899 3,242 1,779
Accretion of debt discount and amortization of deferred financing costs 10,587 9,459 4,378
Deferred income taxes (156) (3,674) (21,278)
Other noncash items 226 837 1,093
Receivables:      
Trade 2,214 (262) (2,698)
Related parties 258 967 11,003
Other 1,853 (656) (542)
Inventory 2,511 4,100 (478)
Prepaid expenses and other (812) (2,262) 1,006
Other assets (142) 333 652
Accounts payable (1,097) (5,349) 4,680
Accrued compensation and benefits (789) 5,186 4,385
Other accrued liabilities (2,682) (5,516) 356
Deferred revenue (21,045) 7,423 (38,578)
Lease liabilities (887) (995) 0
Related party payables (33) 45 (52)
Other long-term liabilities 0 (585) 281
Net cash used in operating activities (77,021) (135,927) (124,240)
Cash flows from investing activities      
Purchases of investments (171,360) (55,073) (178,681)
Sales and maturities of investments 133,000 166,495 65,975
Proceeds from sales of equity securities 0 23,456 217
Acquisitions of businesses, net of cash received 0 0 (920)
Investments in affiliates 0 (3,713) (16,582)
Decrease in cash from deconsolidation of subsidiary 0 (7,244) 0
Return of investment in affiliate 0 125 2,598
Cash received in asset acquisitions 0 0 15,500
Purchases of property, plant and equipment (7,527) (37,883) (41,587)
Proceeds from sale of assets 6,484 688 2,267
Proceeds from sale of discontinued operations, net of cash sold 64,240 0 0
Proceeds from repayment of notes receivable 2,942 0 0
Net cash provided by (used in) investing activities 27,779 86,851 (151,213)
Cash flows from financing activities      
Proceeds from issuance of shares in a private placement 35,000 0 0
Proceeds from issuance of shares and warrants in public offerings, net of issuance costs 0 6,611 87,990
Advances from lines of credit 10,005 11,757 4,561
Repayments of advances from lines of credit (11,927) (10,301) (4,328)
Proceeds from long-term debt, net of issuance costs 0 376 219,859
Payments of long-term debt (490) (618) (623)
Proceeds from stock option and warrant exercises 117 313 2,336
Net cash provided by financing activities 32,705 8,138 309,795
Effect of exchange rate changes on cash, cash equivalents, and restricted cash 353 (810) 295
Net increase (decrease) in cash, cash equivalents, and restricted cash (16,184) (41,748) 34,637
Cash, cash equivalents, and restricted cash      
Beginning of year 68,434 110,182 75,545
End of year 52,250 68,434 110,182
Supplemental disclosure of cash flow information      
Cash paid during the period for interest 7,202 3,751 3,868
Cash paid during the period for income taxes 48 50 216
Significant noncash activities      
Fair value of stock received as consideration for collaboration agreements 0 4,530 0
Fair value of stock issued for reacquired in-process research and development 0 0 159,323
Fair value of stock issued upon conversion of long-term debt 56,827 0 0
Fair value of stock issued in conjunction with settlement agreement 18,103 0 0
Long-term debt issued to a related party in an asset acquisition 0 0 30,000
Accrued compensation paid in equity awards 5,100 1,102 0
Purchases of property and equipment included in accounts payable and other accrued liabilities 277 694 2,267
Purchases of equipment financed through debt 0 0 234
Sales of assets included in receivables $ 4,227 $ 0 $ 0