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Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Income Tax Disclosure [Abstract]
Computed statutory income tax benefit from continuing operations	$ (21,810)	$ (35,965)	$ (83,141)
State and provincial income tax benefit, net of federal income taxes	(5,167)	(5,494)	(21,717)
Nondeductible stock based compensation	5,709	10,303	4,696
Nondeductible officer compensation	728	595	294
Impairment of goodwill	0	273	0
Research and development tax incentives	(524)	(1,772)	(185)
Acquisition and internal restructuring transaction costs	0	260	52
Reacquired in-process research and development	0	0	2,696
Change in deferred state tax rate	0	0	8,666
United States-foreign rate differential	(21)	(76)	215
Other, net	(306)	(72)	(3,517)
Income tax reconciliation income tax benefit before valuation allowance, total	(21,391)	(31,948)	(91,941)
Change in valuation allowance for deferred tax assets	21,309	31,018	76,516
Total income tax benefit from continuing operations	$ (82)	$ (930)	$ (15,425)

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to adjustments for acquisition-related transaction costs.

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic deferred state income tax rates, attributable to increase (decrease) in the income tax rates.

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Income Tax Reconciliation Income Tax Expense Benefit Before Valuation Allowance

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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