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Income Taxes - Additional Information (Details) - USD ($)
$ in Thousands
Dec. 31, 2020
Dec. 31, 2019
Operating Loss Carryforwards [Line Items]    
Federal and state research and development tax credits $ 10,210 $ 9,686
Accumulated deficit (1,823,390) $ (1,652,869)
Foreign Subsidiaries    
Operating Loss Carryforwards [Line Items]    
Accumulated deficit 21,200  
Domestic    
Operating Loss Carryforwards [Line Items]    
Net operating losses inherited via acquisition 42,100  
Operating loss carryforwards 756,200  
Deferred tax assets, capital loss carryforwards 211,500  
Federal and state research and development tax credits 10,200  
Foreign    
Operating Loss Carryforwards [Line Items]    
Operating loss carryforwards 82,300  
Generated after 2017 | Domestic    
Operating Loss Carryforwards [Line Items]    
Operating loss carryforwards $ 503,500