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  <xs:element id="pgen_ContractWithCustomerAssetAndLiabilityTable" abstract="true" name="ContractWithCustomerAssetAndLiabilityTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="pgen_DisposalGroupIncludingDiscontinuedOperationsLongTermDebtCurrentMaturities" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationsLongTermDebtCurrentMaturities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_DisposalGroupIncludingDiscontinuedOperationOwnershipInterestDisposedOf" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationOwnershipInterestDisposedOf" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="pgen_StockIssuedDuringPeriodSharesStockOptionsExercisedAndRestrictedStockAwards" abstract="false" name="StockIssuedDuringPeriodSharesStockOptionsExercisedAndRestrictedStockAwards" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="pgen_JointVentureAdditionalCapitalContributionsCommitted" abstract="false" name="JointVentureAdditionalCapitalContributionsCommitted" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_CompensationArrangementWithIndividualExpense" abstract="false" name="CompensationArrangementWithIndividualExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_CapitalExpendituresNetOfProceedsFromSaleOfAssetsAndInvestmentsInAffiliates" abstract="false" name="CapitalExpendituresNetOfProceedsFromSaleOfAssetsAndInvestmentsInAffiliates" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_DisposalGroupIncludingDiscontinuedOperationOtherAccruedLiabilities" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationOtherAccruedLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_PrecigenStockOptionPlanMember" abstract="true" name="PrecigenStockOptionPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_NetIncomeLossAttributabletoParentAdjustedEBITDAIncludingCashPaidforCapitalExpendituresandInvestmentsinAffiliates" abstract="false" name="NetIncomeLossAttributabletoParentAdjustedEBITDAIncludingCashPaidforCapitalExpendituresandInvestmentsinAffiliates" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_NumberofSeatsonGoverningBoard" abstract="false" name="NumberofSeatsonGoverningBoard" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="pgen_IntrexonEnergyPartnersMember" abstract="true" name="IntrexonEnergyPartnersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_DisposalGroupIncludingDiscontinuedOperationCostsOfServices" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationCostsOfServices" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_IntrexonEnergyPartnersLLAndIntrexonEnergyPartnersIILLCMember" abstract="true" name="IntrexonEnergyPartnersLLAndIntrexonEnergyPartnersIILLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_IntrexonEnergyPartnersIILLCMember" abstract="true" name="IntrexonEnergyPartnersIILLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_BiopharmaceuticalsSegmentMember" abstract="true" name="BiopharmaceuticalsSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_TransOvaMember" abstract="true" name="TransOvaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_GeneratedAfter2017Member" abstract="true" name="GeneratedAfter2017Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_PrecigenStockOptionPlan2019PlanMember" abstract="true" name="PrecigenStockOptionPlan2019PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_DisposalGroupIncludingDiscontinuedOperationReimbursementLimit" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationReimbursementLimit" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_EliminationsAndReconcilingItemsMember" abstract="true" name="EliminationsAndReconcilingItemsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_LongLivedAssetsIncludingPropertyPlantandEquipmentandRightOfUseAssets" abstract="false" name="LongLivedAssetsIncludingPropertyPlantandEquipmentandRightOfUseAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_PrepaidProductAndServiceRevenuesMember" abstract="true" name="PrepaidProductAndServiceRevenuesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_RelatedPartyOwnershipInterest" abstract="false" name="RelatedPartyOwnershipInterest" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="pgen_CompensationArrangementWithIndividualAllocatedShareBasedCompensationExpenseMonthlyExpense" abstract="false" name="CompensationArrangementWithIndividualAllocatedShareBasedCompensationExpenseMonthlyExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_ComputerHardwareandSoftware" abstract="false" name="ComputerHardwareandSoftware" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_DisposalGroupIncludingDiscontinuedOperationsRightOfUseAssets" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationsRightOfUseAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_AllInvestorsMember" abstract="true" name="AllInvestorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_ContractWithCustomerAssetAndLiabilityLineItems" abstract="true" name="ContractWithCustomerAssetAndLiabilityLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="pgen_DeferredRevenueOtherMember" abstract="true" name="DeferredRevenueOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_PrecigenStockOptionPlan2013PlanMember" abstract="true" name="PrecigenStockOptionPlan2013PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_MBPTitanMember" abstract="true" name="MBPTitanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_RelatedPartyReceivableAllowanceforCreditLossCurrent" abstract="false" name="RelatedPartyReceivableAllowanceforCreditLossCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_OtherMember" abstract="true" name="OtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_StockIssuedDuringPeriodValueRestrictedStockAwardsVestedAndStockOptionsExercised" abstract="false" name="StockIssuedDuringPeriodValueRestrictedStockAwardsVestedAndStockOptionsExercised" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsReconciliationAbstract" abstract="true" name="CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsReconciliationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="pgen_ShareLendingAgreementLengthOfTimeForSharesToBeReturnedUponTermination" abstract="false" name="ShareLendingAgreementLengthOfTimeForSharesToBeReturnedUponTermination" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="pgen_LesseeOperatingLeaseTerminationPeriod" abstract="false" name="LesseeOperatingLeaseTerminationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="pgen_ExemplarGeneticsLLCMember" abstract="true" name="ExemplarGeneticsLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_DisposalGroupIncludingDiscontinuedOperationsLongTermDebtExcludingCurrentMaturities" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationsLongTermDebtExcludingCurrentMaturities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopment" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_AdjustmentForBonusesPaidInEquityAwards" abstract="false" name="AdjustmentForBonusesPaidInEquityAwards" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_InterestExpenseDebtAmortizationofDebtDiscountPremiumandDebtIssuanceCosts" abstract="false" name="InterestExpenseDebtAmortizationofDebtDiscountPremiumandDebtIssuanceCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_PrecigenStockOptionPlan2008PlanMember" abstract="true" name="PrecigenStockOptionPlan2008PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_CompensationArrangementWithIndividualAnnualRSUGrantGrantDateFairValue" abstract="false" name="CompensationArrangementWithIndividualAnnualRSUGrantGrantDateFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_ExemplarSegmentMember" abstract="true" name="ExemplarSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_LockupPeriodOnRestrictedStockUnitShares" abstract="false" name="LockupPeriodOnRestrictedStockUnitShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="pgen_ReportableSegmentsMember" abstract="true" name="ReportableSegmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_CostOfProductsMember" abstract="true" name="CostOfProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_CorporateAndReconcilingItemsMember" abstract="true" name="CorporateAndReconcilingItemsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_ExecutiveChairmanMember" abstract="true" name="ExecutiveChairmanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_PrecigenAndRemainingIEPInvestorsMember" abstract="true" name="PrecigenAndRemainingIEPInvestorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_AmericanStateBankMember" abstract="true" name="AmericanStateBankMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_StockIssuedDuringThePeriodSharesAccruedCompensation" abstract="false" name="StockIssuedDuringThePeriodSharesAccruedCompensation" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="pgen_AccruedCompensationPaidinEquityAwards" abstract="false" name="AccruedCompensationPaidinEquityAwards" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_SaleOfAssetsIncludedInAccountsReceivable" abstract="false" name="SaleOfAssetsIncludedInAccountsReceivable" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_RelatedPartiesAggregatedMember" abstract="true" name="RelatedPartiesAggregatedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_DisposalGroupIncludingDiscontinuedOperationEarnOutPayments" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationEarnOutPayments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_SuppliesEmbryosAndOtherProductionMaterialsMember" abstract="true" name="SuppliesEmbryosAndOtherProductionMaterialsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="pgen_PercentageOfRevenueAttributableToCustomer" abstract="false" name="PercentageOfRevenueAttributableToCustomer" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="pgen_SharesIssuedDuringPeriodValueIssuedForServices" abstract="false" name="SharesIssuedDuringPeriodValueIssuedForServices" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_CollaborationandLicensingRevenueTableTextBlock" abstract="false" name="CollaborationandLicensingRevenueTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="pgen_CompensationArrangementWithIndividualAnnualStockOptionGrantGrantDateFairValue" abstract="false" name="CompensationArrangementWithIndividualAnnualStockOptionGrantGrantDateFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="pgen_NumberofSeatsonGoverningBoardInternallySelected" abstract="false" name="NumberofSeatsonGoverningBoardInternallySelected" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="pgen_CashCashEquivalentsRestrictedCashAndShortTermInvestments" abstract="false" name="CashCashEquivalentsRestrictedCashAndShortTermInvestments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
