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Condensed Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 9 Months Ended | 12 Months Ended
--- | --- | ---
Sep. 30, 2023 | Sep. 30, 2022 | Dec. 31, 2022 | Dec. 31, 2021
Cash flows from operating activities: |  |  |  |
Net loss | $ (101,733) | $ (76,453) | $ (101,052) | $ (70,760)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |
Net amortization of premiums and discounts on investments in marketable securities | (3,422) | (479) | (1,600) | 0
Depreciation and amortization | 2,265 | 1,670 | 2,352 | 734
Non-cash lease expense | 3,860 | 4,454 | 5,994 | 1,460
Stock-based compensation expense | 8,269 | 9,912 | 13,534 | 7,871
Loss on disposal of assets | 71 | 0 |  |
Impairment of assets | 43,276 | 0 |  |
Change in fair value of the Series A redeemable convertible preferred stock tranche liability |  |  | 0 | 10,341
Changes in assets and liabilities: |  |  |  |
Assets held for sale | (20) | 0 |  |
Prepaid expenses and other current assets and other assets | 4,884 | (2,437) | (3,211) | (3,914)
Accounts payable | 1,145 | 1,275 | 194 | 1,825
Accrued compensation | (1,900) | 657 | 1,110 | 2,223
Accrued research costs | (690) | (280) | 87 | (1,131)
Accrued expenses and other current liabilities and other liabilities | 2,479 | 399 | 94 | 257
Operating lease liabilities | (2,614) | (4,269) | (5,482) | (1,758)
Net cash used in operating activities | (44,130) | (65,551) | (87,980) | (52,852)
Cash flows from investing activities: |  |  |  |
Purchases of property and equipment | (10,806) | (5,573) | (6,594) | (5,740)
Proceeds from sales of property and equipment | 1,225 | 0 |  |
Purchases of investments in marketable securities | (28,130) | (339,814) | (405,519) | 0
Proceeds from maturities of marketable securities | 216,975 | 90,000 | 170,250 | 0
Net cash provided by (used in) investing activities | 179,264 | (255,387) | (241,863) | (5,740)
Cash flows from financing activities: |  |  |  |
Proceeds from issuance of common stock upon exercise of vested stock options | 34 | 18 | 20 | 28
Proceeds from employee stock purchase plan | 157 | 414 | 656 | 306
Proceeds from issuance of redeemable convertible preferred stock, net of issuance costs |  |  | 0 | 165,521
Proceeds from initial public offering, net of issuance costs |  |  | 0 | 251,323
Proceeds from issuance of common stock upon early exercises of stock options |  |  | 0 | 289
Repurchase of unvested early exercised shares and founders' shares | (67) | (79) | (79) | 0
Net cash provided by financing activities | 124 | 353 | 597 | 417,467
Net increase (decrease) in cash, cash equivalents and restricted cash | 135,258 | (320,585) | (329,246) | 358,875
Cash, cash equivalents and restricted cash, at beginning of period | 49,446 | 378,692 | 378,692 | 19,817
Cash, cash equivalents and restricted cash, at end of period | 184,704 | 58,107 | 49,446 | 378,692
Reconciliation of cash, cash equivalents and restricted cash to statement of financial position: |  |  |  |
Cash and cash equivalents | 182,988 | 56,391 | 47,730 | 376,976
Restricted cash | 1,716 | 1,716 | 1,716 | 1,716
Cash, cash equivalents and restricted cash in statement of financial position | 184,704 | 58,107 | 49,446 | 378,692
Supplemental disclosures of non-cash investing and financing information: |  |  |  |
Property and equipment purchases in accounts payable and accrued expenses | 0 | (319) | (36) | (75)
Conversion of redeemable convertible preferred stock to common stock at closing of initial public offering |  |  | 0 | 260,532
Settlement of redeemable convertible preferred stock tranche liability |  |  | 0 | (39,403)
Lessor funded lease incentive additions included in property and equipment | 7,193 | 2,616 | 11,920 | 0
Repurchase of unvested early exercised shares included in accounts payable |  |  | (17) | (42)
Proceeds from issuance of common stock upon exercise of stock options included in accounts receivable |  |  |  | (14)
Proceeds from sale of property and equipment in accounts receivable | 449 | 0 |  |
Additions to ROU assets from new operating lease liabilities | 31,974 | 0 | 0 | 13,034
Vesting of early exercised stock options | $ 48 | $ 108 | $ 131 | $ 144

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