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Net Loss Per Share (Tables)
12 Months Ended
Dec. 31, 2020
Earnings Per Share [Abstract]  
Summary of Basic and Diluted Net Loss Per Share of Common Stock
The following table summarizes the computation of basic and diluted net loss per share of our common stock for 2020, 2019 and 2018:
 Year Ended December 31,
 202020192018
 (in thousands, except share and per share data)
Numerator:
Net loss$(98,849)$(53,845)$(55,545)
Denominator:
Weighted-average common shares outstanding, basic and diluted51,036,824 48,731,791 46,456,825 
Net loss per share, basic and diluted$(1.94)$(1.10)$(1.20)
Anti-Dilutive Securities Excluded from Computation Diluted Weighted Average Shares Outstanding
The following potentially dilutive securities outstanding, prior to the use of the treasury stock method, have been excluded from the computation of diluted weighted-average shares outstanding for the respective periods below because they would have been anti-dilutive:
 Year Ended December 31,
 202020192018
Options to purchase common stock1,933,013 2,705,458 3,713,179 
Unvested restricted stock— — 21,677 
Unvested restricted stock units2,941,914 2,936,924 2,773,773 
Shares to be issued under ESPP101,658 53,167 74,634 
Convertible senior notes9,299,432 5,530,176 5,530,176 
Total14,276,017 11,225,725 12,113,439