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Share-based payments - Long-Term Incentive Plan (LTIP) (Details) |  |  |  |  |  |  |  |  |  |  |  | 1 Months Ended | 12 Months Ended |  |  |  |  |  |  |
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Apr. 01, 2023 Option | Mar. 31, 2023 shares | Apr. 01, 2022 Option € / shares | Mar. 31, 2022 | Mar. 01, 2022 $ / shares | Jan. 01, 2022 Option € / shares | Aug. 01, 2021 Option | Jul. 01, 2021 Option € / shares | Mar. 01, 2021 Option € / shares | Dec. 01, 2020 Option | Nov. 16, 2020 Option € / shares | Jan. 31, 2022 | Dec. 31, 2023 Option | Dec. 31, 2022 Option € / shares | Dec. 31, 2022 $ / shares | Apr. 01, 2022 $ / shares | Jan. 01, 2022 $ / shares | Dec. 31, 2021 € / shares | Dec. 31, 2021 $ / shares | Jul. 01, 2021 $ / shares | Mar. 01, 2021 $ / shares | Nov. 16, 2020 $ / shares
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of options granted | $ / shares |  |  |  |  | $ 19.35 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting percentage (as a percent) |  |  |  |  | 25.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of days increase related to percentage of stock price |  |  |  |  |  |  |  |  |  |  |  |  | 10 days |  |  |  |  |  |  |  |  |
LTIP Stock Options |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of share options granted |  |  |  |  | 130,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
LTIP Stock Options | Chief Scientific Officer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of share options granted |  |  |  |  | 25,000 |  |  |  |  |  | 266,155 |  |  |  |  |  |  |  |  |  |  |
Exercise price of options granted | € / shares |  |  |  |  |  |  |  |  |  |  | € 10.04 |  |  |  |  |  |  |  |  |  |  |
Threshold duration of volume weighted average price |  |  |  |  |  |  |  |  |  |  | 10 days |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  |  |  |  |  |  |  |  |  | 4 years |  |  |  |  |  |  |  |  |  |  |
Vesting percentage (as a percent) |  |  |  |  |  |  |  |  |  |  | 25.00% |  |  |  |  |  |  |  |  |  |  |
Percentage of increase in share price |  |  |  |  |  |  |  |  |  |  | 20.00% |  |  |  |  |  |  |  |  |  |  |
Exercised during the period |  |  |  |  |  |  |  |  |  |  |  |  | 0 | (6,303) |  |  |  |  |  |  |  |
LTIP Stock Options | Chief Business Officer and Chief Commercial Officer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of share options granted |  |  |  |  | 25,000 |  |  |  |  | 266,156 |  |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |  |  |  |  |  |  |
Percentage of increase in share price |  |  |  |  |  |  |  |  |  |  | 10.00% |  |  |  |  |  |  |  |  |  |  |
Number of days increase related to percentage of stock price |  |  |  |  |  |  |  |  |  |  |  |  |  | 10 days |  |  |  |  |  |  |  |
LTIP Stock Options | Chief Business Officer and Chief Commercial Officer | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  |  |  |  |  |  |  |  |  | 1 year |  |  |  |  |  |  |  |  |  |  |
LTIP Stock Options | Chief Business Officer and Chief Commercial Officer | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  |  |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |  |
LTIP Stock Options | Chief Business Officer and Chief Commercial Officer | First tranche |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of options granted | (per share) |  |  |  |  |  |  |  |  |  |  | € 43.87 |  |  | € 81.65 | $ 98.57 |  |  | € 81.48 | $ 98.36 |  |  | $ 52.96
LTIP Stock Options | Chief Business Officer and Chief Commercial Officer | Second tranche |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of options granted | (per share) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | € 33.07 | $ 39.92 |  |  |
LTIP Stock Options | Chief Business Officer and Chief Commercial Officer | Third tranche |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of options granted | (per share) |  |  |  |  |  |  |  |  |  |  |  |  |  | € 7.35 | $ 7.68 |  |  |  |  |  |  |
LTIP Stock Options | Key employees |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of share options granted |  |  | 700 |  |  | 9,500 |  |  | 2,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of options granted | (per share) |  |  | € 17.45 |  |  | € 30.67 |  |  | € 77.73 |  |  |  |  |  |  | $ 19.28 | $ 33.87 |  |  |  | $ 88.16 |
Threshold duration of volume weighted average price |  |  | 10 days | 10 years |  | 30 days |  |  | 10 days |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  | 4 years |  |  | 4 years |  |  | 4 years |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting percentage (as a percent) |  |  | 25.00% |  |  |  |  |  | 25.00% |  |  | 25.00% |  |  |  |  |  |  |  |  |  |
Percentage of increase in share price |  |  | 20.00% |  |  |  |  |  | 10.00% |  |  | 20.00% |  |  |  |  |  |  |  |  |  |
Number of days increase related to percentage of stock price |  |  |  |  |  |  |  |  |  |  |  | 10 days |  |  |  |  |  |  |  |  |  |
LTIP Stock Options | Chief Operating Officer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of share options granted |  |  |  |  | 25,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of options granted | (per share) |  |  |  |  |  |  |  | € 70.92 |  |  |  |  |  |  |  |  |  |  |  | $ 84.03 |  |
Threshold duration of volume weighted average price |  |  |  |  |  |  |  | 20 days |  |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  |  |  |  |  |  | 4 years |  |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting percentage (as a percent) |  |  |  |  |  |  |  | 25.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of increase in share price |  |  |  |  |  |  |  | 20.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of days increase related to percentage of stock price |  |  |  |  |  |  |  | 10 days |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercised during the period |  |  |  |  |  |  |  | (20,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |
LTIP Stock Options | Chief Development Officer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of options granted | (per share) |  |  |  |  |  |  |  | € 46.16 |  |  |  |  |  |  |  |  |  |  |  | $ 54.79 |  |
Vesting period (in years) |  |  |  |  |  |  |  | 4 years |  |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting percentage (as a percent) |  |  |  |  |  |  |  | 25.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of increase in share price |  |  |  |  |  |  |  | 20.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of days increase related to percentage of stock price |  |  |  |  |  |  |  | 10 days |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercised during the period |  |  |  |  |  |  | (30,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
LTIP Stock Options | Chief Financial Officer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of share options granted |  |  |  |  | 25,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
LTIP Stock Options | the Chief Executive Officer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of share options granted | 144,379 |  |  |  | 30,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted Stock Units |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting percentage (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  | 0.33% |  |  |  |  |  |  |  |  |
Restricted Stock Units | LTIP Stock Options |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period (in years) |  |  |  |  |  |  |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |  |
Vesting percentage (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  | 0.33% |  |  |  |  |  |  |  |  |
Restricted Stock Units | Members of supervisory board | LTIP Stock Options |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of share options granted | shares |  | 92,701 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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