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Stock-Based Compensation and Stockholders' Equity (Net Capital Deficiency) (Details 2) (USD $) | 3 Months Ended | 9 Months Ended |  | 12 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended
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Sep. 30, 2012 | Sep. 30, 2011 | Sep. 30, 2012 | Sep. 30, 2011 | Sep. 30, 2012 Stock options | Sep. 30, 2012 RSUs | Sep. 30, 2012 RSAs | Dec. 31, 2011 RSAs Employee Performance-Contingent Senior management | Sep. 30, 2012 Research and development | Sep. 30, 2011 Research and development | Sep. 30, 2012 Research and development | Sep. 30, 2011 Research and development | Dec. 31, 2011 Research and development RSAs Employee Performance-Contingent Senior management | Sep. 30, 2012 General and administrative | Sep. 30, 2011 General and administrative | Sep. 30, 2012 General and administrative | Sep. 30, 2011 General and administrative | Dec. 31, 2011 General and administrative RSAs Employee Performance-Contingent Senior management
Allocation of stock-based compensation expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | $ 5,830,000 | $ 6,890,000 | $ 18,044,000 | $ 18,706,000 |  |  |  |  | $ 3,259,000 | $ 3,510,000 | $ 10,329,000 | $ 10,021,000 |  | $ 2,571,000 | $ 3,380,000 | $ 7,715,000 | $ 8,685,000 |
Information related to share-based compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Timeframe for performance targets |  |  |  |  |  |  |  | 6 years |  |  |  |  |  |  |  |  |  |
Total unrecognized compensation cost related to unvested stock-based compensation |  |  |  |  | 6,500,000 | 16,900,000 | 25,600,000 |  |  |  |  |  |  |  |  |  |  |
Maximum potential expenses associated with 2011 performance-contingent restricted stock grant |  |  |  |  |  |  |  | $ 31,900,000 |  |  |  |  | $ 6,300,000 |  |  |  |  | $ 25,600,000

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- Definition Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph A240 -Subparagraph g(1) -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph 64 -Subparagraph b -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=6793087&loc=d3e301413-122809 + Details
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- Definition As of the balance sheet date, the aggregate unrecognized cost of equity-based awards made to employees under equity-based compensation awards that have yet to vest. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (i) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph A240 -Subparagraph h -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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- Definition Estimated period over which an employee is required to provide service in exchange for the equity-based payment award, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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