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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Cash flows from operating activities |  |  |
Net income (loss) | $ 134,272 | $ 59,536 | $ (18,760)
Adjustments to reconcile net income (loss) to net cash provided by operating activities: |  |  |
Depreciation and amortization | 13,982 | 13,954 | 13,933
Stock-based compensation | 9,833 | 8,297 | 6,873
Amortization of debt discount and issuance costs | 5,116 | 2,847 | 2,943
Loss (gain) on extinguishment of debt | 7,256 | (2,342) | 0
Amortization of discount on short term investment | (105) | (9) | 583
Amortization of lease guarantee | (325) | (190) | 0
Interest added to the principal balance of the non-recourse term notes due 2029 | 0 | 855 | 22,635
Realized gain on sale of marketable securities, net | 0 | 0 | (1,220)
Other non-cash items | 0 | 0 | (3)
Changes in operating assets and liabilities: |  |  |
Receivables from collaborative arrangements | (23,693) | (20,619) | (15,678)
Prepaid expenses and other current assets | 12 | 48 | 320
Other assets | 0 | (19) | 0
Accounts payable | 473 | (690) | 818
Payable to Theravance Biopharma, Inc., net | 0 | 0 | (1,056)
Accrued personnel-related expenses and other accrued liabilities | (81) | 276 | (725)
Accrued interest payable | (1,908) | (83) | 360
Other long-term liabilities | 16 | 8 | (7)
Deferred revenue | (3,099) | (885) | (885)
Net cash provided by operating activities | 141,749 | 60,984 | 10,131
Cash flows from investing activities |  |  |
Maturities of marketable securities | 44,387 | 88,422 | 137,621
Purchases of marketable securities | (67,623) | (95,719) | (86,523)
Sales of marketable securities | 0 | 2,995 | 108,077
Purchases of property and equipment | 0 | (278) | (7)
Net cash (used in) provided by investing activities | (23,236) | (4,580) | 159,168
Cash flows from financing activities |  |  |
Proceeds from senior secured term loans | 250,000 | 0 | 0
Proceeds from issuance of convertible senior notes due 2025 | 192,500 | 0 | 0
Payments of debt issuance costs and debt discount | (12,803) | 0 | 0
Payment of principal on non-recourse notes due 2029 | (487,189) | (6,828) | 0
Repurchase of shares to satisfy tax withholding | (2,128) | (1,079) | (2,192)
Payments of principal on senior secured term loans | 6,250 | 0 | 0
Payments of cash dividends to stockholders | (281) | (960) | (87,331)
Proceeds from issuances of common stock, net | 435 | 385 | 8,240
Repurchase of common stock | (97,500) | (78,094) | (25,636)
Repurchase of convertible subordinated notes due 2023 | 0 | (11,570) | 0
Proceeds from capped-call options | 0 | 578 | 0
Contributions from noncontrolling interest | 23 | 0 | 0
Net cash used in financing activities | (163,193) | (97,568) | (106,919)
Net (decrease) increase in cash and cash equivalents | (44,680) | (41,164) | 62,380
Cash and cash equivalents at beginning of period | 118,016 | 159,180 | 96,800
Cash and cash equivalents at end of period | 73,336 | 118,016 | 159,180
Supplemental disclosure of cash flow information |  |  |
Cash paid for interest | $ 40,353 | $ 48,797 | $ 25,863

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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the issuance of a long-term debt instrument which can be exchanged for a specified amount of another security, typically the entity's common stock, at the option of the issuer or the holder. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The cash inflow provided by derivative instruments during the period, which are classified as financing activities, excluding those designated as hedging instruments. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 23 -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3505-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The cash inflow from amounts received from issuance of long-term debt that is wholly or partially secured by collateral. Excludes proceeds from tax exempt secured debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with maturities (principal being due), prepayments and calls (requests of early payments) on securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 + Details
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- Definition Amount of cash inflow from a noncontrolling interest. Includes, but is not limited to, purchase of additional shares or other increase in noncontrolling interest ownership. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the sale of debt and equity securities classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 + Details
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- Definition The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4K -URI http://asc.fasb.org/extlink&oid=84234705&loc=SL4591552-111686 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 45 -Paragraph 19 -URI http://asc.fasb.org/extlink&oid=96868048&loc=SL4569616-111683 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=84161450&loc=SL4573702-111684 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4J -URI http://asc.fasb.org/extlink&oid=84234705&loc=SL4591551-111686 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=84161450&loc=SL4573702-111684 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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