<SEC-DOCUMENT>0000899140-20-000297.txt : 20200612
<SEC-HEADER>0000899140-20-000297.hdr.sgml : 20200612
<ACCEPTANCE-DATETIME>20200612173029
ACCESSION NUMBER:		0000899140-20-000297
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20200612
DATE AS OF CHANGE:		20200612

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Entasis Therapeutics Holdings Inc.
		CENTRAL INDEX KEY:			0001724344
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				824592913
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90651
		FILM NUMBER:		20961209

	BUSINESS ADDRESS:	
		STREET 1:		35 GATEHOUSE DRIVE
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451
		BUSINESS PHONE:		(781) 810-0120

	MAIL ADDRESS:	
		STREET 1:		35 GATEHOUSE DRIVE
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Entasis Therapeutics Ltd
		DATE OF NAME CHANGE:	20171204

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Innoviva, Inc.
		CENTRAL INDEX KEY:			0001080014
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				943265960
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		2000 SIERRA POINT PARKWAY
		STREET 2:		SUITE 500
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005
		BUSINESS PHONE:		6502389600

	MAIL ADDRESS:	
		STREET 1:		2000 SIERRA POINT PARKWAY
		STREET 2:		SUITE 500
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	THERAVANCE INC
		DATE OF NAME CHANGE:	20020207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADVANCED MEDICINE INC
		DATE OF NAME CHANGE:	20000302
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>i35408460a.htm
<DESCRIPTION>SCHEDULE 13D/A (AMENDMENT NO. 1)
<TEXT>
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    <div style="text-align: center; margin-right: 166.6pt; margin-left: 166.9pt; margin-top: 4.45pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; margin-right: 166.6pt; margin-left: 167pt; margin-top: 0.5pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; margin-right: 166.45pt; margin-left: 167pt; margin-top: 2.05pt; font-weight: bold;">Washington, D.C.&#160; 20549</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="margin-top: 0.5pt;"><br>
    </div>
    <div style="text-align: center; margin-right: 166.6pt; margin-left: 166.95pt; font-size: 14pt; font-weight: bold;">SCHEDULE 13D/A</div>
    <div style="text-align: center; margin-right: 178.95pt; margin-left: 179.45pt; margin-top: 1.35pt; font-weight: bold;">Under the Securities Exchange Act of 1934 </div>
    <div style="text-align: center; margin-right: 178.95pt; margin-left: 179.45pt; margin-top: 1.35pt; font-weight: bold;">(Amendment No. 1)*</div>
    <div><br>
    </div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">ENTASIS THERAPEUTICS HOLDINGS INC.</div>
    <div style="margin-top: 0.1pt;">
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; margin-right: 166.6pt; margin-left: 166.9pt; margin-top: 1.15pt;">(Name of Issuer)</div>
    <div style="margin-top: 1.15pt;"><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Common Stock, $0.001 par value</div>
    <div style="margin-top: 0.1pt;">
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; margin-right: 166.55pt; margin-left: 167pt; margin-top: 1.15pt;">(Title of Class of Securities)</div>
    <div style="margin-top: 1.15pt;"><br>
    </div>
    <div style="text-align: center; font-weight: bold;">293614 103</div>
    <div style="margin-top: 0.1pt;">
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; margin-right: 166.6pt; margin-left: 166.9pt; margin-top: 1.15pt;">(CUSIP Number)</div>
    <div style="margin-top: 1.15pt;"><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Geoffrey Hulme</div>
    <div style="text-align: center; font-weight: bold;">Interim Principal Executive Officer</div>
    <div style="text-align: center; font-weight: bold;">Innoviva, Inc.</div>
    <div style="text-align: center; font-weight: bold;">1350 Old Bayshore Highway Suite 400</div>
    <div style="text-align: center; font-weight: bold;">Burlingame, CA</div>
    <div style="text-align: center; font-weight: bold;">877-202-1097</div>
    <div style="margin-top: 0.1pt;">
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="margin: 1.15pt 0px 0px; font-family: 'Times New Roman',Times,serif; text-align: center; text-indent: -55.1pt;">(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)</div>
    <div style="margin-top: 1.15pt;"><br>
    </div>
    <div style="text-align: center; font-weight: bold;">June 11, 2020</div>
    <div style="margin-top: 0.25pt;">
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="font-family: 'Times New Roman',Times,serif; text-align: center;">(Date of Event which Requires Filing of this Statement)</div>
    <div style="margin-top: 0.45pt;"><br>
    </div>
    <div style="text-align: justify; margin-right: 60.15pt; margin-left: 59pt;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of
      &#167;&#167;240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. &#9744;</div>
    <div style="margin-top: 0.45pt;"><br>
    </div>
    <div style="text-align: justify; margin-right: 60.2pt; margin-left: 59pt; margin-top: 4.55pt;"><font style="font-weight: bold;">Note</font>: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all
      exhibits. See &#167;240.13d-7 for other parties to whom copies are to be sent.</div>
    <div><br>
    </div>
    <div style="text-align: justify; margin-right: 60.05pt; margin-left: 58.95pt; margin-top: 0.05pt;"><font style="font-size: 8pt;">* </font>The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with
      respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.</div>
    <div><br>
    </div>
    <div style="text-align: justify; margin-right: 60.15pt; margin-left: 58.95pt; margin-top: 0.05pt;">The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange
      Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="margin-right: 117.45pt; margin-left: 86pt; margin-top: 5.75pt; font-weight: bold;">Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB
      control number.</div>
    <div style="margin-top: 0.1pt;"><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div><br>
    </div>
    <div style="margin-left: 23.6pt; margin-top: 3.7pt;">CUSIP No. ..<font style="font-weight: bold;">&#160;</font>04216R 102...</div>
    <div style="margin: 3.7pt 0px 0px;"> <br>
    </div>
    <div style="margin: 3.7pt 0px 0px;"> <br>
    </div>
    <div style="margin: 3.7pt 0px 0px;">
      <div>
        <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 12pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

            <tr>
              <td style="width: 7.75%; vertical-align: top; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt; text-align: center;">&#160;&#160;<font style="font-weight: bold;">1</font>&#160;</div>
              </td>
              <td style="width: 1.55%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;</div>
              </td>
              <td colspan="5" style="width: 90.71%; vertical-align: top; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">Names of Reporting Persons.<br>
                </div>
                <div style="font-size: 10pt;">I.R.S. Identification Nos. of above persons (entities only).<br>
                </div>
                <div>&#160;</div>
                <div style="margin-bottom: 1pt;">
                  <div style="font-size: 10pt;"><u>Innoviva, Inc.</u></div>
                </div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 7.75%; vertical-align: top; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt; text-align: center;">&#160;&#160;<font style="font-weight: bold;">2</font></div>
              </td>
              <td style="width: 1.55%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">&#160;</div>
              </td>
              <td colspan="5" style="width: 90.71%; vertical-align: top; border-right: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
                <div style="font-size: 10pt;">(a)&#160;&#160;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)&#160;&#160;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
                <div style="margin-bottom: 1pt;">&#160;</div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 7.75%; vertical-align: top; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt; text-align: center;">&#160;&#160;<font style="font-weight: bold;">3</font></div>
              </td>
              <td style="width: 1.55%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;</div>
              </td>
              <td colspan="5" style="width: 90.71%; vertical-align: top; border-right: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">SEC USE ONLY</div>
                <div style="margin-bottom: 1pt;">&#160;</div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 7.75%; vertical-align: top; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt; text-align: center;">&#160;&#160;<font style="font-weight: bold;">4</font></div>
              </td>
              <td style="width: 1.55%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;</div>
              </td>
              <td colspan="5" style="width: 90.71%; vertical-align: top; border-right: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">SOURCE OF FUNDS</div>
                <div>&#160;</div>
                <div style="margin-bottom: 1pt;">WC</div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 7.75%; vertical-align: top; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt; text-align: center;">&#160;&#160;<font style="font-weight: bold;">5</font></div>
              </td>
              <td style="width: 1.55%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;</div>
              </td>
              <td colspan="5" style="width: 90.71%; vertical-align: top; border-right: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)</div>
                <div>&#160;</div>
                <div style="margin-bottom: 1pt; font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 7.75%; vertical-align: top; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt; text-align: center;">&#160;&#160;<font style="font-weight: bold;">6</font></div>
              </td>
              <td style="width: 1.55%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;</div>
              </td>
              <td colspan="5" style="width: 90.71%; vertical-align: top; border-right: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
                <div>&#160;</div>
                <div style="margin-bottom: 1pt;">Delaware</div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" rowspan="4" style="width: 17.03%; vertical-align: middle; border-left: #000000 2px solid;">
                <div style="text-align: center; font-size: 10pt;">NUMBER&#160;OF</div>
                <div style="text-align: center; font-size: 10pt;">SHARES</div>
                <div style="text-align: center; font-size: 10pt;">BENEFICIALLY</div>
                <div style="text-align: center; font-size: 10pt;">OWNED&#160;BY</div>
                <div style="text-align: center; font-size: 10pt;">EACH</div>
                <div style="text-align: center; font-size: 10pt;">REPORTING</div>
                <div style="text-align: center; font-size: 10pt;">PERSON</div>
                <div style="text-align: center; font-size: 10pt;">WITH</div>
                <div style="margin-bottom: 1pt; font-size: 10pt;">&#160;</div>
                <div>&#160;</div>
              </td>
              <td style="width: 1.37%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;&#160;</div>
              </td>
              <td style="width: 2.76%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt; text-align: center;">&#160;&#160;<font style="font-weight: bold;">7</font>&#160;</div>
              </td>
              <td style="width: 1.37%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;&#160;</div>
              </td>
              <td style="width: 77.48%; vertical-align: top; border-right: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">SOLE VOTING POWER</div>
                <div>&#160;</div>
                <div style="margin-bottom: 1pt;">28,000,000 <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1.55%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;&#160;</div>
              </td>
              <td style="width: 7.74%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt; text-align: center;">&#160;&#160;<font style="font-weight: bold;">8</font></div>
              </td>
              <td style="width: 1.37%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;&#160;</div>
              </td>
              <td style="width: 2.76%; vertical-align: top; border-right: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">SHARED VOTING POWER</div>
                <div>&#160;</div>
                <div style="margin-bottom: 1pt;">0<br>
                </div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1.55%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;&#160;</div>
              </td>
              <td style="width: 7.74%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt; text-align: center;">&#160;&#160;<font style="font-weight: bold;">9</font></div>
              </td>
              <td style="width: 1.37%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;&#160;</div>
              </td>
              <td style="width: 2.76%; vertical-align: top; border-right: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">SOLE DISPOSITIVE POWER</div>
                <div>&#160;</div>
                <div style="margin-bottom: 1pt;">28,000,000 <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1.55%; vertical-align: bottom; border-left: #000000 2px solid;">
                <div>&#160;&#160;</div>
              </td>
              <td style="width: 7.74%; vertical-align: top;">
                <div style="font-size: 10pt; font-weight: bold; text-align: center;">10</div>
              </td>
              <td style="width: 1.37%; vertical-align: bottom; border-left: #000000 2px solid;">
                <div>&#160;&#160;</div>
              </td>
              <td style="width: 2.76%; vertical-align: top; border-right: #000000 2px solid;">
                <div style="font-size: 10pt;">SHARED DISPOSITIVE POWER</div>
                <div>&#160;</div>
                <div style="margin-bottom: 1pt;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">0</sup></div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 7.75%; vertical-align: top; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt; font-weight: bold; text-align: center;">11</div>
              </td>
              <td style="width: 1.55%; vertical-align: bottom; border-left: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;</div>
              </td>
              <td colspan="5" style="width: 90.71%; vertical-align: top; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
                <div>&#160;</div>
                <div style="margin-bottom: 1pt;">28,000,000 <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 7.75%; vertical-align: top; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt; font-weight: bold; text-align: center;">12</div>
              </td>
              <td style="width: 1.55%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;</div>
              </td>
              <td colspan="5" style="width: 90.71%; vertical-align: top; border-right: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES</div>
                <div>&#160;</div>
                <div style="margin-bottom: 1pt; font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 7.75%; vertical-align: top; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt; font-weight: bold; text-align: center;">13</div>
              </td>
              <td style="width: 1.55%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;</div>
              </td>
              <td colspan="5" style="width: 90.71%; vertical-align: top; border-right: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
                <div>&#160;</div>
                <div style="margin-bottom: 1pt;">67.8% <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup><br>
                </div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 7.75%; vertical-align: top; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt; font-weight: bold; text-align: center;">14</div>
              </td>
              <td style="width: 1.55%; vertical-align: bottom; border-left: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div>&#160;</div>
              </td>
              <td colspan="5" style="width: 90.71%; vertical-align: top; border-right: #000000 2px solid; border-bottom: #000000 2px solid;">
                <div style="font-size: 10pt;">TYPE OF REPORTING PERSON</div>
                <div>&#160;</div>
                <div style="margin-bottom: 1pt;">CO</div>
                <div>&#160;</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <br>
    <div>
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              <div style="margin-left: 18pt; margin-top: 0.5pt;">(1)</div>
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              <div style="margin-top: 0.5pt;">Based on 14,614,073 shares of Common Stock outstanding as of April 30, 2020 (inclusive of the 1,322,510 shares of Common Stock issued by the Issuer to the Reporting Person on April 23, 2020), as reported by the
                Issuer in its Form 10-Q filed on May 7, 2020, <u>plus</u> (i) 12,677,490 shares of Common Stock issued by the Issuer to the Reporting Person on June 11, 2020 and (ii) Warrants to purchase 14,000,000 shares of Common Stock held by the
                Reporting Person.</div>
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    <div style="margin-left: 22.4pt; font-weight: bold;">Explanatory Note</div>
    <div style="margin-top: 0.4pt;"><br>
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    <div style="text-align: justify; margin-right: 23.65pt; margin-left: 36pt; margin-top: 0.05pt;">This Amendment No. 1 (the &#8220;Amendment No. 1&#8221;) amends and supplements the initial Statement of Beneficial Ownership on Schedule 13D, as filed with the
      Securities and Exchange Commission on April 23, 2020 (the &#8220;<font style="font-style: italic;">Schedule 13D</font>&#8221;) with respect to shares of common stock, $0.001 par value per share (&#8220;<font style="font-style: italic;">Common Stock</font>&#8221;), of
      Entasis Therapeutics Holdings Inc., a Delaware corporation (the &#8220;<font style="font-style: italic;">Issuer</font>&#8221;) and warrants to acquire additional shares of Common Stock of the Issuer, which are exercisable immediately and will have a five year
      term (&#8220;<font style="font-style: italic;">Warrants</font>&#8221;). Innoviva, Inc. (the &#8220;<font style="font-style: italic;">Reporting Person</font>&#8221;) is filing this amendment to reflect the acquisition of additional shares of Common Stock and Warrants. Except
      as specifically amended and supplemented by this Amendment No. 1, the Schedule 13D remains in full force and effect.</div>
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    <div style="margin-left: 23.6pt; margin-top: 0.05pt; font-weight: bold;">Item 3. Source and Amount of Funds or Other Consideration</div>
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    <div style="margin-left: 36pt;">Item 3 in Schedule 13D is hereby supplemented as follows:</div>
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    <div style="margin-left: 36pt; font-size: 12pt;"><font style="font-size: 10pt;">The aggregate purchase price for the Common Stock and Warrants reported in this Amendment No. 1 was approximately $31.7 million. The Common Stock and Warrants reported in
        this Amendment No. 1 were acquired with funds provided from working capital of the Reporting Person</font>.</div>
    <div style="margin-top: 0.15pt;"><br>
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    <div style="margin-left: 23.55pt; margin-top: 0.05pt; font-weight: bold;">Item 4. Purpose of Transaction</div>
    <div style="margin-left: 36pt; margin-top: 12pt; margin-bottom: 12pt;">Item 4 in Schedule 13D is hereby supplemented as follows:</div>
    <div style="margin-left: 36pt; margin-top: 12pt; margin-bottom: 12pt;">As previously disclosed on the Schedule 13D, on April 23, 2020, the Reporting Person entered into that certain Securities Purchase Agreement with the Issuer (the &#8220;<font style="font-style: italic;">Purchase Agreement</font>&#8221;), pursuant to which the Issuer agreed to issue and sell to the Reporting Person, in a private placement, up to 14,000,000 newly issued shares of Common Stock and Warrants to purchase up to
      14,000,000 shares of Common Stock, with an exercise price per share of $2.50.</div>
    <div style="margin-left: 36pt; margin-top: 12pt; margin-bottom: 12pt;">On April 22, 2020 and in connection with the first closing under the Purchase Agreement, the Issuer issued to the Reporting Person 1,322,510 shares of Common Stock and Warrants to
      acquire an additional 1,322,510 shares of Common Stock of the Issuer (the &#8220;<font style="font-style: italic;">First Issuance</font>&#8221;). As previously disclosed on the Schedule 13D, as a result of, and immediately following, the First Issuance, the
      Reporting Person beneficially owned approximately 19.99% of the Issuer's outstanding shares of Common Stock.</div>
    <div style="margin-left: 36pt; margin-top: 12pt; margin-bottom: 12pt;">At a special meeting of stockholders held on June 10, 2020 (the &#8220;<font style="font-style: italic;">Special Meeting</font>&#8221;), the Issuer's stockholders approved the issuance of the
      shares of Common Stock and Warrants to the Reporting Person in the second tranche of the private placement. On June 11, 2020, the Issuer issued to the Reporting Person 12,677,490 shares of Common Stock and Warrants to acquire an additional 12,677,490
      shares of Common Stock of the Issuer (the &#8220;<font style="font-style: italic;">Second Issuance</font>&#8221;). The Warrants, at an exercise price per share of $2.50, are exercisable immediately and have a five year term. Each share of Common Stock and
      Warrant (together, a &#8220;<font style="font-style: italic;">Common Unit</font>&#8221;) have been issued and sold together at price per Common Unit of $2.50. As a result of the Second Issuance, the Reporting Person acquired control of the Issuer, owning
      approximately 51.3% of the Issuer&#8217;s outstanding shares of Common Stock without the exercise of the Warrants. If the Reporting Person exercises the Warrants in their entirety, it will own approximately 67.8% of the Issuer&#8217;s outstanding shares of
      Common Stock.</div>
    <div style="margin-left: 36pt; margin-top: 12pt; margin-bottom: 12pt;">At the Special Meeting, the Issuer&#8217;s stockholders approved an amendment to the Issuer&#8217;s Amended and Restated Certificate of Incorporation (the &#8220;<font style="font-style: italic;">Charter</font>&#8221;)



      to renounce any interest or expectancy of the Issuer in, or in being offered an opportunity to participate in, any business opportunity that is presented to the Issuer&#8217;s directors, officers or stockholders (the &#8220;<font style="font-style: italic;">Corporate



        Opportunities Amendment</font>&#8221;). Promptly following such vote, on June 10, 2020, the Issuer filed the Certificate of Amendment to the Charter with the Secretary of State of the State of Delaware to effect the Corporate Opportunities Amendment,
      effective upon filing.</div>
    <div style="margin-left: 36pt;">The Reporting Person purchased the Common Stock and Warrants reported in this Amendment No. 1 for investment purposes.</div>
    <div style="margin-left: 23.55pt; margin-top: 0.05pt;"><font style="font-weight: bold;"> </font><br>
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    <div style="margin-left: 23.55pt; margin-top: 0.05pt; font-weight: bold;">Item 5. Interest in Securities of the Issuer</div>
    <div style="margin-left: 36pt; margin-top: 12pt; margin-bottom: 12pt;">Item 5 in Schedule 13D is hereby amended and restated as follows:</div>
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              <div style="margin-left: 18pt; margin-top: 0.5pt;">(2)</div>
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              <div style="margin-top: 0.5pt;">The Reporting Person has sole voting power and sole dispositive power with regard to 28,000,000 shares of Common Stock, representing approximately 67.8% of the outstanding shares of Common Stock of the Issuer
                as of the date of this Schedule 13D, based on 14,614,073 shares of Common Stock outstanding as of April 30, 2020, as reported by the Issuer in its Form 10-Q filed on May 7, 2020 (which includes 1,322,510 shares of Common Stock issued by the
                Issuer to the Reporting Person at the First Issuance), <u>plus</u> (i) 12,677,490 shares of Common Stock issued by the Issuer to the Reporting Person on June 11, 2020 and (ii) Warrants to purchase an aggregate of 14,000,000 shares of
                Common Stock held by the Reporting Person following the Second Issuance. Except as set forth in Item 4, the Reporting Person did not acquire or sell any shares of Common Stock or other securities of the Issuer during the last 60 days.</div>
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    <div style="text-align: center; margin-left: 23pt; font-weight: bold;">SIGNATURE</div>
    <div style="margin-top: 0.45pt;"><br>
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    <div style="text-align: justify; text-indent: 36pt; margin-right: 23.6pt; margin-left: 23pt;">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-right: 23.6pt; margin-left: 23pt;">Dated: June 12, 2020</div>
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    <div style="text-indent: 36pt; margin-right: 23.6pt; margin-left: 23pt;"><font style="font-weight: bold;">INNOVIVA, INC.<br>
      </font><br>
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    <div style="text-indent: 36pt; margin-right: 23.6pt; margin-left: 23pt; font-weight: bold;">By: <u>/s/ Geoffrey Hulme &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;</u></div>
    <div style="margin-right: 23.6pt; margin-left: 36pt; font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Name: Geoffrey Hulme</div>
    <div style="margin-right: 23.6pt; margin-left: 36pt; font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Title: Interim Principal Executive Officer</div>
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