<SEC-DOCUMENT>0001315863-20-000990.txt : 20201214
<SEC-HEADER>0001315863-20-000990.hdr.sgml : 20201214
<ACCEPTANCE-DATETIME>20201214080301
ACCESSION NUMBER:		0001315863-20-000990
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20201214
DATE AS OF CHANGE:		20201214
GROUP MEMBERS:		ALEXANDER J. DENNER, PH.D.
GROUP MEMBERS:		SARISSA CAPITAL CATAPULT FUND LLC
GROUP MEMBERS:		SARISSA CAPITAL HAWKEYE FUND LP
GROUP MEMBERS:		SARISSA CAPITAL MASTER FUND II LP
GROUP MEMBERS:		SARISSA CAPITAL OFFSHORE MASTER FUND LP

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Innoviva, Inc.
		CENTRAL INDEX KEY:			0001080014
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				943265960
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-80415
		FILM NUMBER:		201385122

	BUSINESS ADDRESS:	
		STREET 1:		2000 SIERRA POINT PARKWAY
		STREET 2:		SUITE 500
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005
		BUSINESS PHONE:		6502389600

	MAIL ADDRESS:	
		STREET 1:		2000 SIERRA POINT PARKWAY
		STREET 2:		SUITE 500
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	THERAVANCE INC
		DATE OF NAME CHANGE:	20020207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADVANCED MEDICINE INC
		DATE OF NAME CHANGE:	20000302

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sarissa Capital Management LP
		CENTRAL INDEX KEY:			0001577524
		IRS NUMBER:				900924432
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203-302-2330

	MAIL ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>sc_13da_innoviva.htm
<TEXT>
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          <div style="text-align: center; text-indent: -10pt; margin-left: 10pt; font-size: 12pt; font-weight: bold;">UNITED STATES</div>
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          <div style="text-align: center; text-indent: -10pt; margin-left: 10pt; font-weight: bold;">Washington, D.C. 20549</div>
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          <div style="text-align: center; text-indent: -10pt; margin-left: 10pt; font-family: 'Times New Roman', serif; font-size: 1pt; font-weight: bold;">&#160;</div>
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          <div style="text-align: center; text-indent: -10pt; margin-left: 10pt; font-size: 12pt; font-weight: bold;">SCHEDULE 13D</div>
        </td>
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          <div style="font-family: 'Times New Roman', serif; font-size: 1pt; font-weight: bold;">&#160;</div>
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  <div>&#160;</div>
  <div style="text-align: center; font-weight: bold;">Under the Securities Exchange Act of 1934<br>
    (Amendment No.&#160;1)*</div>
  <div style="text-align: center; font-size: 12pt;">&#160;</div>
  <div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-size: 18pt; font-weight: bold;">Innoviva, Inc.</div>
  </div>
  <div style="text-align: center;">(Name of Issuer)</div>
  <div style="text-align: center; font-size: 12pt;">&#160;</div>
  <div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-weight: bold;">Common Stock, $0.01 par value</div>
  </div>
  <div style="text-align: center;">(Title of Class of Securities)</div>
  <div style="text-align: center; font-size: 12pt;">&#160;</div>
  <div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-weight: bold;">45781M101</div>
  </div>
  <div style="text-align: center;">(CUSIP Number)</div>
  <div style="text-align: center;">&#160;</div>
  <div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-weight: bold;">Mark DiPaolo</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-weight: bold;">Senior Partner and General Counsel</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-weight: bold;">Sarissa Capital Management LP</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-weight: bold;">660 Steamboat Road</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-weight: bold;">Greenwich, CT 06830</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-weight: bold;">203-302-2330</div>
  </div>
  <div style="text-align: center;">(Name, Address and Telephone Number of Person<br>
    Authorized to Receive Notices and Communications)</div>
  <div style="text-align: center; font-size: 12pt;">&#160;</div>
  <div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-weight: bold;">December 11, 2020</div>
  </div>
  <div style="text-align: center;">(Date of Event Which Requires Filing of this Statement)<br>
    <br>
  </div>
  <div style="margin-right: 36pt; margin-left: 36pt;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e), 13d-1(f)
    or 13d-1(g), check the following box. &#9633;</div>
  <div style="margin-right: 36pt; margin-left: 36pt; margin-top: 5pt; margin-bottom: 5pt;"><font style="font-weight: bold;">Note</font>: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all
    exhibits. See Rule 13d-7 for other parties to whom copies are to be sent.</div>
  <div style="margin-right: 36pt; margin-left: 36pt; margin-top: 5pt; margin-bottom: 5pt; font-size: 8pt;">*<font style="font-size: 10pt;">&#160;The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with
      respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.</font></div>
  <div style="margin-right: 36pt; margin-left: 36pt;">The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the
    liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
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          <td style="width: 50.00%;">
            <div><font style="font-size: 12pt;">CUSIP No. 45781M101</font> <br>
            </div>
          </td>
          <td style="width: 50%; font-size: 12pt;">
            <div style="text-align: right;">&#160;Page <u>2</u> of <u>10</u><br>
            </div>
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  <div style="font-size: 12pt;"> </div>
  <div style="font-size: 12pt; text-align: center;"> <br>
    SCHEDULE 13D<br>
  </div>
  <div style="font-size: 12pt; text-align: center;"> <br>
  </div>
  <div style="font-size: 12pt;"> <br>
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        <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;&#160;1&#160;</div>
        </td>
        <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;</div>
        </td>
        <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
          <div style="font-size: 12pt;">NAME OF REPORTING PERSON OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON<br>
          </div>
          <div style="font-size: 12pt;">&#160;</div>
          <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">
            <div>Sarissa Capital Management LP</div>
          </div>
        </td>
      </tr>
      <tr>
        <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;&#160;2</div>
        </td>
        <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;</div>
        </td>
        <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
          <div style="font-size: 12pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
          <div style="font-size: 12pt;"> <br>
          </div>
          <div style="font-size: 12pt;">(a)&#160;&#160;&#9744;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)&#160;&#160;&#9744;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;&#160;3</div>
        </td>
        <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;</div>
        </td>
        <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
          <div style="font-size: 12pt;">SEC USE ONLY</div>
          <div style="font-size: 12pt;">&#160;</div>
          <div style="font-size: 12pt;"> <br>
          </div>
        </td>
      </tr>
      <tr>
        <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;&#160;4</div>
        </td>
        <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;</div>
        </td>
        <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
          <div style="font-size: 12pt;">SOURCE OF FUNDS</div>
          <div style="font-size: 12pt;">&#160;</div>
          <div style="font-size: 12pt;">AF</div>
        </td>
      </tr>
      <tr>
        <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;&#160;5</div>
        </td>
        <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;</div>
        </td>
        <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
          <div style="font-size: 12pt;">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR</div>
          <div style="font-size: 12pt;">2(e)&#160;&#160;&#9744;</div>
          <div style="font-size: 12pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;&#160;6</div>
        </td>
        <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;</div>
        </td>
        <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
          <div style="font-size: 12pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
          <div style="font-size: 12pt;">&#160;</div>
          <div style="font-size: 12pt;">DELAWARE<br>
          </div>
        </td>
      </tr>
      <tr>
        <td style="width: 18.41%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="4" colspan="3">
          <div style="text-align: center; font-size: 12pt;">NUMBER&#160;OF</div>
          <div style="text-align: center; font-size: 12pt;">SHARES</div>
          <div style="text-align: center; font-size: 12pt;">BENEFICIALLY</div>
          <div style="text-align: center; font-size: 12pt;">OWNED&#160;BY</div>
          <div style="text-align: center; font-size: 12pt;">EACH</div>
          <div style="text-align: center; font-size: 12pt;">REPORTING</div>
          <div style="text-align: center; font-size: 12pt;">PERSON</div>
          <div style="text-align: center; font-size: 12pt;">WITH</div>
          <div style="font-size: 12pt;">&#160;</div>
        </td>
        <td style="width: 1.68%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">&#160;&#160;</div>
        </td>
        <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">&#160;&#160;7&#160;</div>
        </td>
        <td style="width: 1.56%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">&#160;&#160;</div>
        </td>
        <td style="width: 70%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">SOLE VOTING POWER</div>
          <div style="font-size: 12pt;">&#160;</div>
          <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">
            <div>755,400</div>
          </div>
        </td>
      </tr>
      <tr>
        <td style="width: 1.69%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">&#160;&#160;</div>
        </td>
        <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">&#160;&#160;8</div>
        </td>
        <td style="width: 1.68%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">&#160;&#160;</div>
        </td>
        <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">SHARED&#160;VOTING POWER</div>
          <div style="font-size: 12pt;">&#160;</div>
          <div style="font-size: 12pt;">5,658,600<br>
          </div>
        </td>
      </tr>
      <tr>
        <td style="width: 1.69%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">&#160;&#160;</div>
        </td>
        <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">&#160;&#160;9</div>
        </td>
        <td style="width: 1.68%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">&#160;&#160;</div>
        </td>
        <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">SOLE DISPOSITIVE POWER</div>
          <div style="font-size: 12pt;">&#160;</div>
          <div style="font-size: 12pt;">755,400<br>
          </div>
        </td>
      </tr>
      <tr>
        <td style="width: 1.69%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">&#160;&#160;</div>
        </td>
        <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">10</div>
        </td>
        <td style="width: 1.68%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">&#160;&#160;</div>
        </td>
        <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-size: 12pt;">SHARED&#160;DISPOSITIVE POWER</div>
          <div style="font-size: 12pt;">&#160;</div>
          <div style="font-size: 12pt;">5,658,600<br>
          </div>
        </td>
      </tr>
      <tr>
        <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">11</div>
        </td>
        <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;</div>
        </td>
        <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
          <div style="font-size: 12pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
          <div style="font-size: 12pt;">&#160;</div>
          <div style="font-size: 12pt;">6,414,000<br>
          </div>
        </td>
      </tr>
      <tr>
        <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">12</div>
        </td>
        <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;</div>
        </td>
        <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
          <div style="font-size: 12pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES&#160;&#160;&#9744;</div>
          <div style="font-size: 12pt;"> <br>
          </div>
          <div style="font-size: 12pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">13</div>
        </td>
        <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;</div>
        </td>
        <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
          <div style="font-size: 12pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
          <div style="font-size: 12pt;">&#160;</div>
          <div style="font-size: 12pt;">6.33%</div>
        </td>
      </tr>
      <tr>
        <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">14</div>
        </td>
        <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
          <div style="font-size: 12pt;">&#160;</div>
        </td>
        <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
          <div style="font-size: 12pt;">TYPE OF REPORTING PERSON</div>
          <div style="font-size: 12pt;">&#160;</div>
          <div style="font-size: 12pt;">PN, IA<br>
          </div>
        </td>
      </tr>

  </table>
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      <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
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  <div style="text-align: center; font-size: 12pt;">
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;">

          <tr>
            <td style="width: 50.00%;">
              <div><font style="font-size: 12pt;">CUSIP No. 45781M101</font> <br>
              </div>
            </td>
            <td style="width: 50%; font-size: 12pt;">
              <div style="text-align: right;">&#160;Page <u>3</u> of <u>10</u><br>
              </div>
            </td>
          </tr>

      </table>
    </div>
  </div>
  <div style="text-align: center; font-size: 12pt;"> <br>
  </div>
  <div style="text-align: center; font-size: 12pt;">&#160;SCHEDULE 13D</div>
  <div style="text-align: center; font-size: 12pt;"> <br>
  </div>
  <div></div>
  <div>
    <div style="font-size: 12pt;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z5e38090cb03c4bc991d869287f4241f0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;1&#160;</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">NAME OF REPORTING PERSON OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">
              <div>Alexander J. Denner, Ph.D.</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;2</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
            <div style="font-size: 12pt;"> <br>
            </div>
            <div style="font-size: 12pt;">(a)&#160;&#160;&#9744;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)&#160;&#160;&#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;3</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">SEC USE ONLY</div>
            <div style="font-size: 12pt;"> <br>
            </div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;4</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">SOURCE OF FUNDS</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">AF</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;5</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR</div>
            <div style="font-size: 12pt;">2(e)&#160;&#160;&#9744;</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;6</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">UNITED STATES<br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 18.41%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="4" colspan="3">
            <div style="text-align: center; font-size: 12pt;">NUMBER&#160;OF</div>
            <div style="text-align: center; font-size: 12pt;">SHARES</div>
            <div style="text-align: center; font-size: 12pt;">BENEFICIALLY</div>
            <div style="text-align: center; font-size: 12pt;">OWNED&#160;BY</div>
            <div style="text-align: center; font-size: 12pt;">EACH</div>
            <div style="text-align: center; font-size: 12pt;">REPORTING</div>
            <div style="text-align: center; font-size: 12pt;">PERSON</div>
            <div style="text-align: center; font-size: 12pt;">WITH</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;7&#160;</div>
          </td>
          <td style="width: 1.56%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 70%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SOLE VOTING POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;"><br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;8</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SHARED&#160;VOTING POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">
              <div style="font-family: 'Times New Roman',Times,serif;">6,414,000</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;9</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SOLE DISPOSITIVE POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;"><br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">10</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">SHARED&#160;DISPOSITIVE POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">
              <div style="font-family: 'Times New Roman',Times,serif;">6,414,000</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">11</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">
              <div style="font-family: 'Times New Roman',Times,serif;">6,414,000</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">12</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES&#160;&#160;&#9744;</div>
            <div style="font-size: 12pt;"> <br>
            </div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">13</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">6.33%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">14</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">TYPE OF REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">IN, HC<br>
            </div>
          </td>
        </tr>

    </table>
  </div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
    <div style="page-break-after: always;" id="DSPFPageBreak">
      <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
  </div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;">

        <tr>
          <td style="width: 50.00%;">
            <div><font style="font-size: 12pt;">CUSIP No. 45781M101</font> <br>
            </div>
          </td>
          <td style="width: 50%; font-size: 12pt;">
            <div style="text-align: right;">&#160;Page <u>4</u> of <u>10</u><br>
            </div>
          </td>
        </tr>

    </table>
  </div>
  <div> </div>
  <br>
  <div style="text-align: center; font-size: 12pt;">&#160;SCHEDULE 13D</div>
  <div style="text-align: center; font-size: 12pt;"> <br>
  </div>
  <div><br>
  </div>
  <div>
    <table cellspacing="0" cellpadding="0" id="z1917b7ebb0a646b89fd90056a1d20501" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;1&#160;</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">NAME OF REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">
              <div style="font-family: 'Times New Roman',Times,serif;">Sarissa Capital Offshore Master Fund LP</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;2</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
            <div style="font-size: 12pt;"> <br>
            </div>
            <div style="font-size: 12pt;">(a)&#160;&#160;&#9744;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)&#160;&#160;&#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;3</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">SEC USE ONLY</div>
            <div style="font-size: 12pt;"> <br>
            </div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;4</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">SOURCE OF FUNDS</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">WC<br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;5</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR</div>
            <div style="font-size: 12pt;">2(e)&#160;&#160;&#9744;</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;6</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">CAYMAN ISLANDS<br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 18.41%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="4" colspan="3">
            <div style="text-align: center; font-size: 12pt;">NUMBER&#160;OF</div>
            <div style="text-align: center; font-size: 12pt;">SHARES</div>
            <div style="text-align: center; font-size: 12pt;">BENEFICIALLY</div>
            <div style="text-align: center; font-size: 12pt;">OWNED&#160;BY</div>
            <div style="text-align: center; font-size: 12pt;">EACH</div>
            <div style="text-align: center; font-size: 12pt;">REPORTING</div>
            <div style="text-align: center; font-size: 12pt;">PERSON</div>
            <div style="text-align: center; font-size: 12pt;">WITH</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;7&#160;</div>
          </td>
          <td style="width: 1.56%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 70%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SOLE VOTING POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">
              <div style="font-family: 'Times New Roman',Times,serif;">3,607,125</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;8</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SHARED&#160;VOTING POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;"><br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;9</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SOLE DISPOSITIVE POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">3,607,125</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">10</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">SHARED&#160;DISPOSITIVE POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;"><br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">11</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">3,607,125</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">12</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES&#160;&#160;&#9744;</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">13</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">3.56%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">14</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">TYPE OF REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">PN</div>
          </td>
        </tr>

    </table>
  </div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
    <div style="page-break-after: always;" id="DSPFPageBreak">
      <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
  </div>
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  </div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div>
    <div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;">

          <tr>
            <td style="width: 50.00%;">
              <div><font style="font-size: 12pt;">CUSIP No. 45781M101</font> <br>
              </div>
            </td>
            <td style="width: 50%; font-size: 12pt;">
              <div style="text-align: right;">&#160;Page <u>5</u> of <u>10</u><br>
              </div>
            </td>
          </tr>

      </table>
    </div>
  </div>
  <div>
    <div style="text-align: center;"><font style="font-size: 12pt;"> <br>
      </font></div>
    <div style="text-align: center;"><font style="font-size: 12pt;">&#160;SCHEDULE 13D</font></div>
    <div style="text-align: center;"><font style="font-size: 12pt;"> <br>
      </font></div>
    <div>
      <div>
        <div style="font-size: 12pt;">&#160;</div>
        <table cellspacing="0" cellpadding="0" id="zda3a54077d9f4ad7b65b7ff9ec4d2207" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;1&#160;</div>
              </td>
              <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;</div>
              </td>
              <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
                <div style="font-size: 12pt;">NAME OF REPORTING PERSON</div>
                <div style="font-size: 12pt;">&#160;</div>
                <div style="font-size: 12pt;">
                  <div style="font-family: 'Times New Roman',Times,serif;">Sarissa Capital Catapult Fund LLC</div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;2</div>
              </td>
              <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;</div>
              </td>
              <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
                <div style="font-size: 12pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
                <div style="font-size: 12pt;"> <br>
                </div>
                <div style="font-size: 12pt;">(a)&#160;&#160;&#9744;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)&#160;&#160;&#9744; <br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;3</div>
              </td>
              <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;</div>
              </td>
              <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
                <div style="font-size: 12pt;">SEC USE ONLY</div>
                <div style="font-size: 12pt;">&#160;</div>
                <div style="font-size: 12pt;"> <br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;4</div>
              </td>
              <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;</div>
              </td>
              <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
                <div style="font-size: 12pt;">SOURCE OF FUNDS</div>
                <div style="font-size: 12pt;">&#160;</div>
                <div style="font-size: 12pt;">WC<br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;5</div>
              </td>
              <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;</div>
              </td>
              <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
                <div style="font-size: 12pt;">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR</div>
                <div style="font-size: 12pt;">2(e)&#160;&#160;&#9744;</div>
                <div style="font-size: 12pt;">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;6</div>
              </td>
              <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;</div>
              </td>
              <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
                <div style="font-size: 12pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
                <div style="font-size: 12pt;">&#160;</div>
                <div style="font-size: 12pt;">DELAWARE</div>
              </td>
            </tr>
            <tr>
              <td style="width: 18.41%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="4" colspan="3">
                <div style="text-align: center; font-size: 12pt;">NUMBER&#160;OF</div>
                <div style="text-align: center; font-size: 12pt;">SHARES</div>
                <div style="text-align: center; font-size: 12pt;">BENEFICIALLY</div>
                <div style="text-align: center; font-size: 12pt;">OWNED&#160;BY</div>
                <div style="text-align: center; font-size: 12pt;">EACH</div>
                <div style="text-align: center; font-size: 12pt;">REPORTING</div>
                <div style="text-align: center; font-size: 12pt;">PERSON</div>
                <div style="text-align: center; font-size: 12pt;">WITH</div>
                <div style="font-size: 12pt;">&#160;</div>
              </td>
              <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;</div>
              </td>
              <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;7&#160;</div>
              </td>
              <td style="width: 1.56%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;</div>
              </td>
              <td style="width: 70%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">SOLE VOTING POWER</div>
                <div style="font-size: 12pt;">&#160;</div>
                <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">
                  <div>1,147,700</div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;</div>
              </td>
              <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;8</div>
              </td>
              <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;</div>
              </td>
              <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">SHARED&#160;VOTING POWER</div>
                <div style="font-size: 12pt;">&#160;</div>
                <div style="font-size: 12pt;"><br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;</div>
              </td>
              <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;9</div>
              </td>
              <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;&#160;</div>
              </td>
              <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">SOLE DISPOSITIVE POWER</div>
                <div style="font-size: 12pt;">&#160;</div>
                <div style="font-size: 12pt;">1,147,700</div>
              </td>
            </tr>
            <tr>
              <td style="width: 1.69%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-size: 12pt;">&#160;&#160;</div>
              </td>
              <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-size: 12pt;">10</div>
              </td>
              <td style="width: 1.68%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-size: 12pt;">&#160;&#160;</div>
              </td>
              <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="font-size: 12pt;">SHARED&#160;DISPOSITIVE POWER</div>
                <div style="font-size: 12pt;">&#160;</div>
                <div style="font-size: 12pt;"><br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">11</div>
              </td>
              <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;</div>
              </td>
              <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
                <div style="font-size: 12pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
                <div style="font-size: 12pt;">&#160;</div>
                <div style="font-size: 12pt;">1,147,700</div>
              </td>
            </tr>
            <tr>
              <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">12</div>
              </td>
              <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;</div>
              </td>
              <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
                <div style="font-size: 12pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES&#160;&#160;&#9744;</div>
                <div style="font-size: 12pt;">&#160;</div>
                <div style="font-size: 12pt;"> <br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">13</div>
              </td>
              <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;</div>
              </td>
              <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
                <div style="font-size: 12pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
                <div style="font-size: 12pt;">&#160;</div>
                <div style="font-size: 12pt;">1.13%</div>
              </td>
            </tr>
            <tr>
              <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">14</div>
              </td>
              <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                <div style="font-size: 12pt;">&#160;</div>
              </td>
              <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
                <div style="font-size: 12pt;">TYPE OF REPORTING PERSON</div>
                <div style="font-size: 12pt;">&#160;</div>
                <div style="font-size: 12pt;">OO<br>
                </div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
        <div><br>
        </div>
        <div><br>
        </div>
      </div>
    </div>
  </div>
  <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
    <div id="DSPFPageBreak" style="page-break-after:always;">
      <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
  </div>
  <div style="font-size: 12pt; text-align: center;"> <br>
  </div>
  <div style="font-size: 12pt; text-align: center;">
    <div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;">

          <tr>
            <td style="width: 50.00%;">
              <div><font style="font-size: 12pt;">CUSIP No. 45781M101</font> <br>
              </div>
            </td>
            <td style="width: 50%; font-size: 12pt;">
              <div style="text-align: right;">&#160;Page <u>6</u> of <u>10</u><br>
              </div>
            </td>
          </tr>

      </table>
    </div>
  </div>
  <div style="font-size: 12pt; text-align: center;"> <br>
  </div>
  <div style="font-size: 12pt; text-align: center;">&#160;SCHEDULE 13D</div>
  <div style="font-size: 12pt; text-align: center;"> <br>
  </div>
  <div></div>
  <div>
    <div style="font-size: 12pt;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="zd9a5c3c6058c4935bc73bdded12001ae" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;1&#160;</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">NAME OF REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">
              <div style="font-family: 'Times New Roman',Times,serif;">Sarissa Capital Hawkeye Fund LP</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;2</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
            <div style="font-size: 12pt;"> <br>
            </div>
            <div style="font-size: 12pt;">(a)&#160;&#160;&#9744;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)&#160;&#160;&#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;3</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">SEC USE ONLY</div>
            <div style="font-size: 12pt;"> <br>
            </div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;4</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">SOURCE OF FUNDS</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">WC<br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;5</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR</div>
            <div style="font-size: 12pt;">2(e)&#160;&#160;&#9744;</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;6</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">DELAWARE<br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 18.41%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="4" colspan="3">
            <div style="text-align: center; font-size: 12pt;">NUMBER&#160;OF</div>
            <div style="text-align: center; font-size: 12pt;">SHARES</div>
            <div style="text-align: center; font-size: 12pt;">BENEFICIALLY</div>
            <div style="text-align: center; font-size: 12pt;">OWNED&#160;BY</div>
            <div style="text-align: center; font-size: 12pt;">EACH</div>
            <div style="text-align: center; font-size: 12pt;">REPORTING</div>
            <div style="text-align: center; font-size: 12pt;">PERSON</div>
            <div style="text-align: center; font-size: 12pt;">WITH</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;7&#160;</div>
          </td>
          <td style="width: 1.56%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 70%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SOLE VOTING POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">830,900<br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;8</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SHARED&#160;VOTING POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;"><br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;9</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SOLE DISPOSITIVE POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">830,900</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">10</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">SHARED&#160;DISPOSITIVE POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;"><br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">11</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">830,900</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">12</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES&#160;&#160;&#9744;</div>
            <div style="font-size: 12pt;"> <br>
            </div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">13</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">0.82%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">14</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;" colspan="5">
            <div style="font-size: 12pt;">TYPE OF REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">PN</div>
          </td>
        </tr>

    </table>
  </div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
    <div style="page-break-after: always;" id="DSPFPageBreak">
      <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
  </div>
  <div style="text-align: center;">&#160;</div>
  <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt;"> <br>
  </div>
  <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt;">
    <div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;">

          <tr>
            <td style="width: 50.00%;">
              <div><font style="font-size: 12pt;">CUSIP No. 45781M101</font> <br>
              </div>
            </td>
            <td style="width: 50%; font-size: 12pt;">
              <div style="text-align: right;">&#160;Page <u>7</u> of <u>10</u><br>
              </div>
            </td>
          </tr>

      </table>
    </div>
  </div>
  <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt;"> <br>
  </div>
  <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt;">&#160;SCHEDULE 13D</div>
  <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt;"> <br>
  </div>
  <div> </div>
  <div>
    <div style="font-size: 12pt;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z3d365994a7614672aa23fc688bd4c13a" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;1&#160;</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="5">
            <div style="font-size: 12pt;">NAME OF REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">
              <div style="font-family: 'Times New Roman',Times,serif;">Sarissa Capital Master Fund II LP</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;2</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="5">
            <div style="font-size: 12pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
            <div style="font-size: 12pt;"> <br>
            </div>
            <div style="font-size: 12pt;">(a)&#160;&#160;&#9744;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)&#160;&#160;&#9744; <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;3</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="5">
            <div style="font-size: 12pt;">SEC USE ONLY</div>
            <div style="font-size: 12pt;"> <br>
            </div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;4</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="5">
            <div style="font-size: 12pt;">SOURCE OF FUNDS</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">WC<br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;5</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="5">
            <div style="font-size: 12pt;">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR</div>
            <div style="font-size: 12pt;">2(e)&#160;&#160;&#9744;</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;6</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="5">
            <div style="font-size: 12pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">DELAWARE<br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 18.41%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0);" rowspan="4" colspan="3">
            <div style="text-align: center; font-size: 12pt;">NUMBER&#160;OF</div>
            <div style="text-align: center; font-size: 12pt;">SHARES</div>
            <div style="text-align: center; font-size: 12pt;">BENEFICIALLY</div>
            <div style="text-align: center; font-size: 12pt;">OWNED&#160;BY</div>
            <div style="text-align: center; font-size: 12pt;">EACH</div>
            <div style="text-align: center; font-size: 12pt;">REPORTING</div>
            <div style="text-align: center; font-size: 12pt;">PERSON</div>
            <div style="text-align: center; font-size: 12pt;">WITH</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;7&#160;</div>
          </td>
          <td style="width: 1.56%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 70%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">SOLE VOTING POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">72,875<br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;8</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">SHARED&#160;VOTING POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;"><br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;9</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">SOLE DISPOSITIVE POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">72,875</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">10</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">SHARED&#160;DISPOSITIVE POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;"><br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">11</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="5">
            <div style="font-size: 12pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">72,875</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">12</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="5">
            <div style="font-size: 12pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES&#160;&#160;&#9744;</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">13</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="5">
            <div style="font-size: 12pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">0.07%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-size: 12pt;">14</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 89.95%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="5">
            <div style="font-size: 12pt;">TYPE OF REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">PN</div>
          </td>
        </tr>

    </table>
  </div>
  <div> <br>
  </div>
  <div> <br>
  </div>
  <div style="text-align: center;"><br>
  </div>
  <div style="text-align: center;"><br>
  </div>
  <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
    <div style="page-break-after: always;" id="DSPFPageBreak">
      <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
  </div>
  <div style="text-align: center;">&#160;</div>
  <div style="text-align: center;"> <br>
  </div>
  <div style="text-align: center;">
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;">

        <tr>
          <td style="width: 50.00%;">
            <div><font style="font-size: 12pt;">CUSIP No. 45781M101</font> <br>
            </div>
          </td>
          <td style="width: 50%; font-size: 12pt;">
            <div style="text-align: right;">&#160;Page <u>8</u> of <u>10</u><br>
            </div>
          </td>
        </tr>

    </table>
  </div>
  <div style="text-align: center;"> <br>
  </div>
  <div>&#160;</div>
  <div style="font-weight: bold;">Item 1.&#160; Security and Issuer</div>
  <div>&#160;</div>
  <div>This statement constitutes Amendment No. 1 to the Schedule 13D relating to the Common Stock, par value $0.01 (the &#8220;Shares&#8221;), issued by Innoviva,&#160;Inc. (the &#8220;Issuer&#8221;), and hereby amends the Schedule 13D filed with the Securities and Exchange
    Commission on February 25, 2019 (the &#8220;Initial Schedule 13D&#8221;) on behalf of the Reporting Persons (as defined herein), to furnish the additional information set forth herein. &#160;The address of the principal executive offices of the Issuer is 1350 Old
    Bayshore Highway, Suite&#160;400, Burlingame, CA 94010. All capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Initial Schedule 13D.</div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div style="font-weight: bold;">Item 2.&#160; Identity and Background.</div>
  <div><br>
  </div>
  <div>Item 2 is hereby amended and restated to read as follows:</div>
  <div><br>
  </div>
  <div>The persons filing this statement are Sarissa Capital Management LP, a Delaware limited partnership (&#8220;Sarissa Capital&#8221;), Sarissa Capital Offshore Master Fund LP, a Cayman Islands exempted limited partnership (&#8220;Sarissa Offshore&#8221;), Sarissa Capital
    Catapult Fund LLC, a Delaware limited liability company (&#8220;Sarissa Catapult&#8221;), Sarissa Capital Hawkeye Fund LP, a Delaware limited partnership (&#8220;Sarissa Hawkeye&#8221;), Sarissa Capital Master Fund II LP, a Delaware limited partnership (&#8220;Sarissa Master II&#8221;)
    and Alexander J. Denner, Ph.D., a citizen of the United States of America (collectively, the &#8220;Reporting Persons&#8221;).</div>
  <div><br>
  </div>
  <div>The principal business address of (i) each of Sarissa Capital, Sarissa Catapult, Sarissa Hawkeye, Sarissa Master II and Dr. Denner is c/o Sarissa Capital Management LP, 660 Steamboat Road, Greenwich, CT 06830 and (ii) Sarissa Offshore is c/o Ogier
    Fiduciary Services (Cayman) Limited, 89 Nexus Way, Camana Bay, Grand Cayman KY1-9007, Cayman Islands.</div>
  <div><br>
  </div>
  <div>Sarissa Capital&#8217;s principal business is serving as investment advisor to private investment funds (such funds, the &#8220;Sarissa Funds&#8221;), including Sarissa Offshore, Sarissa Catapult, Sarissa Hawkeye and Sarissa Master II.&#160; The ultimate general partner
    of each of Sarissa Capital, Sarissa Offshore, Sarissa Hawkeye and Sarissa Master II, and the managing member of Sarissa Catapult, is controlled by Dr. Denner.&#160; Dr. Denner&#8217;s principal occupation is serving as the Chief Investment Officer of Sarissa
    Capital.</div>
  <div><br>
  </div>
  <div>The name, citizenship, present principal occupation or employment and business address of each director and executive officer of the Reporting Persons are set forth in Schedule A attached hereto.</div>
  <div><br>
  </div>
  <div>None of the Reporting Persons nor any manager or executive officer of the Reporting Persons, has, during the past five years, (a) been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors), or (b) been a party to
    a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting, or mandating activities subject
    to, Federal or State securities laws or a finding of any violation with respect to such laws.</div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div style="font-weight: bold;">Item 4.&#160; Purpose of Transaction.</div>
  <div><br>
  </div>
  <div>Item 4 of the Initial Schedule 13D is hereby amended by adding the following:</div>
  <div>&#160;</div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt;">On December 11, 2020, Sarissa Capital entered into a strategic partnership with the Issuer designed to accelerate the execution of the Issuer&#8217;s strategy and enhance returns on
    its capital.&#160; The partnership comprises (i) a strategic advisory agreement, pursuant to which and subject to the terms set forth therein Sarissa Capital will assist the Issuer in the development of its acquisition strategy and (ii) an investment by the
    Issuer into an investment fund managed by Sarissa Capital to seek to enhance returns on the Issuer&#8217;s capital, as further described herein.</div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt; font-weight: bold;">Strategic Advisory Agreement</div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt;">As part of the partnership, Sarissa Capital and the Issuer entered into a Strategic Advisory Agreement (the &#8220;Services Agreement&#8221;), dated December 11, 2020, pursuant to which
    Sarissa Capital will provide a variety of strategic services to the Issuer in order to assist the Issuer in the development and execution of its acquisition strategy.&#160; Pursuant to the terms of the Services Agreement, and subject to the limitations set
    forth therein, Sarissa Capital will, among other things: (i) assist the Issuer in the development of an overall acquisition and investment process and strategy; (ii) advise the Issuer on market trends, market dynamics and merger and acquisition
    activity; (iii) identify potential transaction targets; (iv) assist in due diligence of transaction targets and the negotiation and execution of private company transactions; (v) advise on the growth and operational plans, performance and integration
    of target companies once an investment or acquisition is made; and (vi) assist in the identification of director and officer candidates for target companies.&#160; The Services Agreement provides for the development of an annual work plan to implement the
    strategic services, and regular collaboration between Sarissa Capital and the Issuer to discuss the work plan and refine the strategic services.</div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt;">The Services Agreement includes customary indemnification and exculpation provisions and is terminable by the Issuer at any time.&#160; In addition, Sarissa Capital may terminate
    the Services Agreement at any time in the event that one or more withdrawal requests to the Partnership (as defined below) are made which, in the aggregate, cause the value of the interest of Strategic Partners (as defined below) in the Partnership to
    be less than 50% of the initial subscription amount, as adjusted for any cumulative profits and losses.</div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt; font-weight: bold;">Investment of Capital</div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt;">In addition to the Services Agreement, on December 11, 2020, Innoviva Strategic Partners LLC, a wholly-owned subsidiary of the Issuer (&#8220;Strategic Partners&#8221;), entered into a
    subscription agreement (the &#8220;Subscription Agreement&#8221;) and an Amended and Restated Limited Partnership Agreement (the &#8220;Partnership Agreement&#8221; and, together with the Subscription Agreement and the other instruments and agreements referenced therein or
    contemplated thereby, the &#8220;Investment Documents&#8221;) pursuant to which Strategic Partners became a limited partner of ISP Fund LP (the &#8220;Partnership&#8221;).&#160; The general partner of the Partnership (the &#8220;General Partner&#8221;) is an affiliate of Sarissa Capital and,
    pursuant to an investment management agreement, Sarissa Capital will act as the investment adviser to the Partnership.</div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt;">Pursuant to the Investment Documents, Strategic Partners made a $300 million initial contribution into the Partnership on a &#8220;most favored nations&#8221; basis.&#160; The Partnership was
    formed for the purposes of investing in &#8220;long-only&#8221; securities in the healthcare, pharmaceutical and biotechnology industries.&#160; The Partnership Agreement provides certain limitations on the General Partner and the Partnership.&#160; Among other things and
    subject to the limitations set forth in the Partnership Agreement, without the prior approval of Strategic Partners, the Partnership may not participate in any borrowing, leverage or other credit arrangement, enter into certain transactions with
    Sarissa Capital or its affiliates or invest greater than 20% of the Net Asset Value (as defined in the Partnership Agreement) of the Partnership in the securities of any single issuer (measured at the time of the acquisition), however, the
    Partnership&#8217;s investments will likely&#160; be concentrated in a few larger positions in order to maximize the synergies between the Partnership Agreement, the Services Agreement and the Issuer&#8217;s overall acquisition strategy.</div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt;"> <br>
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  </div>
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            <div><font style="font-size: 12pt;">CUSIP No. 45781M101</font> <br>
            </div>
          </td>
          <td style="width: 50%; font-size: 12pt;">
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  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt;"> <br>
  </div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt;">As compensation for the advisory services to be provided to the Partnership, the Partnership Agreement provides for Sarissa Capital to receive a customary management fee from
    the Partnership, payable quarterly in advance, measured based on the Net Asset Value of Strategic Partners&#8217; capital account in the Partnership.&#160; In addition, as more fully described in the Partnership Agreement, the General Partner is entitled to a
    customary annual performance allocation based on the Net Profits (as defined in the Partnership Agreement) of the Partnership during the annual measurement period (i.e., the excess during the relevant annual measurement period of (x) operating profits
    of the Partnership plus the realized and unrealized increase in the value of securities held by the Partnership over (y) operating losses of the Partnership plus the realized and unrealized loss in the value of securities held by the Partnership).&#160; The
    performance allocation is payable annually (or a shorter period solely with respect to capital withdrawn from the Partnership prior to year-end) and is calculated based on valuation determinations made by Sarissa Capital or a third-party administrator
    for the Partnership selected by Sarissa Capital.&#160; The foregoing is the sole compensation receivable by Sarissa Capital for the transactions described herein.</div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt;">The Partnership Agreement includes a lock-up period with respect to each capital contribution of thirty-six months after which Strategic Partners is entitled to make
    withdrawals from the Partnership as of such lock-up expiration date and each anniversary thereafter, subject to a 25% gating provision. If Strategic Partners wishes to withdraw more than 25% of its capital, such request will be carried over to the
    successive quarter-end dates until settled in full over a maximum of four quarter-end dates with respect to withdrawal of the full capital account balance. Payments to Strategic Partners in respect of any withdrawal are to be made within 30 days
    following the relevant withdrawal effective date.&#160; In addition, the Partnership Agreement provides for withdrawal rights at any time upon the occurrence of Cause (as defined in the Partnership Agreement) or in the event of a Key Man Event (as defined
    in the Partnership Agreement) tied to Dr. Alexander Denner ceasing to be the Chief Investment Officer of Sarissa Capital or otherwise ceasing to oversee the investment activity of the Partnership. Following a withdrawal due to Cause or a Key Man Event,
    the Partnership is required to distribute withdrawal proceeds as promptly as reasonably practicable following the relevant withdrawal date and without the application of the 25% gate or the lock-up.</div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt;">The Partnership Agreement also provides that Strategic Partners may elect, from time to time, to receive annual distributions of Net Profits (as defined in the Partnership
    Agreement) net of accrued and reserved expenses and fees of the Partnership.&#160; The Partnership Agreement also requires the Partnership to make distributions to Strategic Partners as necessary to allow the Issuer to maintain compliance with the
    Investment Company Act of 1940 and the rules and regulations promulgated thereunder.</div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt;">The Partnership Agreement includes co-investment rights pursuant to which Strategic Partners is entitled to invest ratably in investment opportunities presented to the
    Partnership and other funds and accounts managed by Sarissa Capital and capacity rights pursuant to which Strategic Partners is entitled to make additional investments into the Partnership on the same preferential terms..&#160; The Partnership Agreement
    also includes a customary &#8220;most favored nations&#8221; provision, pursuant to which and subject to certain limitations and conditions, Strategic Partners is entitled to receive the benefit of any more favorable terms or conditions (and any related negative
    terms or obligations) provided to investors in any other fund or account managed by Sarissa Capital or its affiliates pursuing substantially the same investment strategy.</div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt;">In addition to the terms described above, the Investment Documents include other customary terms and conditions, including representations and warranties, indemnities,
    exculpation, information rights and reporting obligations and allocation of third party expenses.</div>
  <div style="text-align: justify; margin-right: 16.25pt; margin-bottom: 12pt;">The foregoing is a summary description of certain terms of the Services Agreement and the Partnership Agreement and does not purport to be complete, and is qualified in its
    entirety by reference to the full text of the Services Agreement, which is filed as Exhibit 2 hereto, and the Partnership Agreement, which is filed as Exhibit 3, each of which is incorporated herein by reference.</div>
  <div style="font-weight: bold;"> <br>
  </div>
  <div style="font-weight: bold;">Item 5.&#160; Interest in Securities of the Issuer.</div>
  <div>&#160;</div>
  <div>Item 5 (a) and (b) of the Initial Schedule 13D are hereby amended and restated as follows:</div>
  <div><br>
  </div>
  <div>(a)&#160;The Reporting Persons may be deemed to beneficially own, in the aggregate, 6,414,000 Shares representing approximately 6.33% of the Issuer&#8217;s outstanding Shares (based upon the 101,391,634 Shares stated to be outstanding as of October 19, 2020 by
    the Issuer in the Issuer&#8217;s Form&#160;10-Q filed with the Securities and Exchange Commission on October 28, 2020).</div>
  <div>&#160;</div>
  <div>(b)&#160;For purposes of this Schedule 13D:</div>
  <div>&#160;</div>
  <div>Sarissa Offshore has sole voting power and sole dispositive power with regard to 3,607,125 Shares.&#160; Sarissa Catapult has sole voting power and sole dispositive power with regard to 1,147,700 Shares.&#160; Sarissa Hawkeye has sole voting power and sole
    dispositive power with regard to 830,900 Shares.&#160; Sarissa Master II has sole voting and sole dispositive power with regard to 72,875 Shares.&#160; Sarissa Capital, as the investment advisor to the Sarissa Funds, may be deemed to have the shared power to
    vote or direct the vote of (and the shared power to dispose or direct the disposition of) the 5,658,600 Shares held by the Sarissa Funds and the sole power to vote or direct the vote of (and the sole power to dispose or direct the disposition of) an
    additional 755,400 Shares held by the Sarissa Funds.&#160; By virtue of his position as the Chief Investment Officer of Sarissa Capital and as the managing member of Sarissa Capital&#8217;s general partner, Dr.&#160;Denner may be deemed to have the shared power to
    vote or direct the vote of (and the shared power to dispose or direct the disposition of) the 6,414,000 Shares held by the Sarissa Funds.</div>
  <div><br>
  </div>
  <div>(c)&#160; The Reporting Persons did not transact in the Shares in the past 60 days.</div>
  <div>&#160;</div>
  <div> <br>
  </div>
  <div style="font-weight: bold;">Item 7.&#160; Material to be Filed as Exhibits.</div>
  <div>&#160;</div>
  <div>Exhibit 1&#160; &#160;&#160; Joint Filing Agreement of the Reporting Persons</div>
  <div><br>
  </div>
  <div>Exhibit 2&#160; &#160; Strategic Advisory Agreement, dated as of December 11, 2020, by and among Sarissa Capital and the Issuer, incorporated by reference to Exhibit 10.1 to the Issuer&#8217;s Current Report on Form 8-K filed with the Securities and Exchange
    Commission on December 11, 2020 (the &#8220;December 8-K&#8221;).</div>
  <div><br>
  </div>
  <div>Exhibit 3&#160; &#160; Amended and Restated Limited Partnership Agreement of ISP Fund LP, dated as of December 10, 2020, by and among ISP Fund LP, Sarissa Capital Fund GP LP, Innoviva Strategic Partners LLC and the other parties named therein, incorporated by
    reference to Exhibit 10.2 to the December 8-K.&#160;</div>
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          <td style="width: 50.00%;">
            <div><font style="font-size: 12pt;">CUSIP No. 45781M101</font> <br>
            </div>
          </td>
          <td style="width: 50%; font-size: 12pt;">
            <div style="text-align: right;">&#160;Page <u>10</u> of <u>10</u><br>
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  <div><br>
  </div>
  <div><br>
  </div>
  <div style="text-align: center; font-weight: bold;">SIGNATURE</div>
  <div>&#160;</div>
  <div style="text-indent: 36pt;">After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this statement is true, complete and correct.</div>
  <div>&#160;</div>
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          <div>Dated: December 14, 2020</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
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          <div>&#160;</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
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        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>SARISSA CAPITAL MANAGEMENT LP</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
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        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
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        <td style="width: 4.34%; vertical-align: top;">
          <div>By:</div>
        </td>
        <td style="width: 45.66%; vertical-align: top;">
          <div><u>/s/ Mark DiPaolo</u></div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
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        <td style="width: 4.34%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.66%; vertical-align: top;">
          <div>Name: Mark DiPaolo</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
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        <td style="width: 4.34%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.66%; vertical-align: top;">
          <div>Title: General Counsel</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
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        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
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          <div>SARISSA CAPITAL OFFSHORE MASTER FUND LP</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
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        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>By: Sarissa Capital Offshore Fund GP LLC, its general partner</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
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        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
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        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.34%; vertical-align: top;">
          <div>By:</div>
        </td>
        <td style="width: 45.66%; vertical-align: top;">
          <div><u>/s/ Mark DiPaolo</u></div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
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        <td style="width: 4.34%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.66%; vertical-align: top;">
          <div>Name: Mark DiPaolo</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
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        <td style="width: 4.34%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.66%; vertical-align: top;">
          <div>Title: Authorized Person</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
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        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
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        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>SARISSA CAPITAL CATAPULT FUND LLC</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
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        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>By: Sarissa Capital Management LP, its managing member</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
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        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.34%; vertical-align: top;">
          <div>By:</div>
        </td>
        <td style="width: 45.66%; vertical-align: top;">
          <div><u>/s/ Mark DiPaolo</u></div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
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        <td style="width: 4.34%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.66%; vertical-align: top;">
          <div>Name: Mark DiPaolo</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.34%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.66%; vertical-align: top;">
          <div>Title: General Counsel</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>SARISSA CAPITAL HAWKEYE FUND LP</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>By: Sarissa Capital Fund GP LP, its general partner</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.34%; vertical-align: top;">
          <div>By:</div>
        </td>
        <td style="width: 45.66%; vertical-align: top;">
          <div><u>/s/ Mark DiPaolo</u></div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.34%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.66%; vertical-align: top;">
          <div>Name: Mark DiPaolo</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.34%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.66%; vertical-align: top;">
          <div>Title: Authorized Person</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>

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          <td style="width: 100%; vertical-align: top;" colspan="2" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;" colspan="2">
            <div>SARISSA CAPITAL MASTER FUND II LP</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;" colspan="2">
            <div>
              <div>By: &#160;Sarissa Capital Offshore Fund GP LLC, its general partner</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;" colspan="2" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;" colspan="2">
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;" colspan="2" rowspan="1"><u>/s/ Mark DiPaolo</u> <br>
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        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;" colspan="2" rowspan="1">Name: Mark DiPaolo <br>
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        <tr>
          <td style="width: 100%; vertical-align: top;" colspan="2" rowspan="1">Title: Authorized Person <br>
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        <tr>
          <td style="width: 100%; vertical-align: top;" colspan="2">
            <div>&#160;</div>
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        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;" colspan="2" rowspan="1">&#160;</td>
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        <tr>
          <td style="width: 100%; vertical-align: top;" colspan="2" rowspan="1"><u>/s/Alexander J. Denner</u> <br>
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        <tr>
          <td style="width: 100%; vertical-align: top;" colspan="2" rowspan="1">Alexander J. Denner <br>
          </td>
        </tr>

    </table>
  </div>
  <div style="clear: both;"><br>
  </div>
  <div><br>
  </div>
  <div>&#160;</div>
  <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
    <div id="DSPFPageBreak" style="page-break-after:always;">
      <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
  </div>
  <div style="text-align: center;"><br>
  </div>
  <div style="text-align: center;"> <br>
  </div>
  <div style="text-align: center;">SCHEDULE 13D</div>
  <div style="text-align: center;">&#160;</div>
  <div style="text-align: right;">EXHIBIT&#160;1</div>
  <div style="text-align: center;">&#160;</div>
  <div style="text-align: center;">JOINT FILING AGREEMENT</div>
  <div>&#160;</div>
  <div>In accordance with Rule&#160;13d-1(k)(1)&#160;under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a statement on Schedule 13D (including amendments thereto) with respect to the
    Common Stock of Innoviva,&#160;Inc. and further agree that this Joint Filing Agreement be included as an Exhibit&#160;to such joint filings. In evidence thereof, the undersigned, being duly authorized, have executed this Joint Filing Agreement this 14<font style="font-size: 8pt;">th</font>&#160;day of December, 2020.</div>
  <div>&#160;</div>
  <div>&#160;</div>
  <table cellspacing="0" cellpadding="0" border="0" align="right" id="zedfc990687374da2af09be6a66ea5f7e" style="width: 60%; color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">

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        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>SARISSA CAPITAL MANAGEMENT LP</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.76%; vertical-align: top;">
          <div>By:</div>
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        <td style="width: 45.26%; vertical-align: top;">
          <div><u>/s/ Mark DiPaolo</u></div>
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        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.76%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.26%; vertical-align: top;">
          <div>Name: Mark DiPaolo</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.76%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.26%; vertical-align: top;">
          <div>Title: General Counsel</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>SARISSA CAPITAL OFFSHORE MASTER FUND LP</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>By: Sarissa Capital Offshore Fund GP LLC, its general partner</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.76%; vertical-align: top;">
          <div>By:</div>
        </td>
        <td style="width: 45.26%; vertical-align: top;">
          <div><u>/s/ Mark DiPaolo</u></div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.76%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.26%; vertical-align: top;">
          <div>Name: Mark DiPaolo</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.76%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.26%; vertical-align: top;">
          <div>Title: Authorized Person</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>SARISSA CAPITAL CATAPULT FUND LLC</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>By: Sarissa Capital Management LP, its managing member</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.76%; vertical-align: top;">
          <div>By:</div>
        </td>
        <td style="width: 45.26%; vertical-align: top;">
          <div><u>/s/ Mark DiPaolo</u></div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.76%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.26%; vertical-align: top;">
          <div>Name: Mark DiPaolo</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.76%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.26%; vertical-align: top;">
          <div>Title: General Counsel</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>SARISSA CAPITAL HAWKEYE FUND LP</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>By: Sarissa Capital Fund GP LP, its general partner</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50.02%; vertical-align: top;" colspan="2">
          <div>&#160;</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.76%; vertical-align: top;">
          <div>By:</div>
        </td>
        <td style="width: 45.26%; vertical-align: top;">
          <div><u>/s/ Mark DiPaolo</u></div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.76%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.26%; vertical-align: top;">
          <div>Name: Mark DiPaolo</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 4.76%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
        <td style="width: 45.26%; vertical-align: top;">
          <div>Title: Authorized Person</div>
        </td>
        <td style="width: 49.98%; vertical-align: top;">
          <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
        </td>
      </tr>

  </table>
  <div style="clear: both;">
    <table cellspacing="0" cellpadding="0" border="0" align="right" style="width: 60%; color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">

        <tr>
          <td style="width: 50.02%; vertical-align: top;" colspan="2">
            <div>&#160;</div>
          </td>
          <td style="width: 49.98%; vertical-align: top;">
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50.02%; vertical-align: top;" colspan="2">
            <div>SARISSA CAPITAL MASTER FUND II LP</div>
          </td>
          <td style="width: 49.98%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50.02%; vertical-align: top;" colspan="2">
            <div>
              <div>By: &#160;Sarissa Capital Offshore Fund GP LLC, its general partner</div>
            </div>
          </td>
          <td style="width: 49.98%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-size: 1pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50.02%; vertical-align: top;" colspan="2" rowspan="1">&#160;</td>
          <td style="width: 49.98%; vertical-align: top;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50.02%; vertical-align: top;" colspan="2">
            <div>&#160;</div>
          </td>
          <td style="width: 49.98%; vertical-align: top;">
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50.02%; vertical-align: top;" colspan="2">
            <div>/s/ Mark DiPaolo <br>
            </div>
          </td>
          <td style="width: 49.98%; vertical-align: top;">
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50.02%; vertical-align: top;" colspan="2" rowspan="1">Name: Mark DiPaolo <br>
          </td>
          <td style="width: 49.98%; vertical-align: top;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50.02%; vertical-align: top;" colspan="2" rowspan="1">Title: Authorized Person <br>
          </td>
          <td style="width: 49.98%; vertical-align: top;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50.02%; vertical-align: top;" colspan="2" rowspan="1">&#160;</td>
          <td style="width: 49.98%; vertical-align: top;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50.02%; vertical-align: top;" colspan="2" rowspan="1">&#160;</td>
          <td style="width: 49.98%; vertical-align: top;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50.02%; vertical-align: top;" colspan="2" rowspan="1"><u>/s/Alexander J. Denner</u> <br>
          </td>
          <td style="width: 49.98%; vertical-align: top;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50.02%; vertical-align: top;" colspan="2" rowspan="1">Alexander J. Denner <br>
          </td>
          <td style="width: 49.98%; vertical-align: top;" rowspan="1">&#160;</td>
        </tr>

    </table>
  </div>
  <div style="clear: both;"><br>
  </div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div></div>
  <div>&#160;</div>
  <div><br>
  </div>
  <div><br>
  </div>
  <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
    <div id="DSPFPageBreak" style="page-break-after:always;">
      <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
  </div>
  <div style="text-align: center; font-size: 12pt;"><u> <br>
    </u></div>
  <u> </u>
  <div><br>
  </div>
  <div style="text-align: center; font-size: 12pt;"><u> <br>
    </u></div>
  <div style="text-align: center; font-size: 12pt;"><u>SCHEDULE A</u></div>
  <div><br>
  </div>
  <div style="text-align: center; font-size: 12pt;">DIRECTORS AND EXECUTIVE OFFICERS OF THE REPORTING PERSONS</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;">The following sets forth the name, position, and principal occupation of each director and executive officer of each of the Reporting Persons. Each such person is a citizen of the United States of America. Except as
    otherwise indicated, the business address of each director and officer is c/o Sarissa Capital Management LP, 660 Steamboat Road, Greenwich, CT 06830. To the best of the Reporting Persons' knowledge, except as set forth in this statement on Schedule
    13D, none of the directors or executive officers of the Reporting Persons own any Ordinary Shares.</div>
  <div><br>
  </div>
  <table cellspacing="0" cellpadding="0" id="zed4df36ba69343fa89e58c2c4e081777" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

      <tr>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-weight: bold;"><u>Name</u></div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div style="font-weight: bold;"><u>Position</u></div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>&#160;</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;">
          <div>Alexander J. Denner, Ph.D.</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>Chief Investment Officer of Sarissa Capital</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;">
          <div>Mark DiPaolo</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>Senior Partner and General Counsel of Sarissa Capital</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;">
          <div>Patrice Bonfiglio</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>Chief Financial Officer and Chief Compliance Officer of Sarissa Capital</div>
        </td>
      </tr>
      <tr>
        <td style="width: 50%; vertical-align: top;">
          <div>Eric Vincent</div>
        </td>
        <td style="width: 50%; vertical-align: top;">
          <div>President of Sarissa Capital</div>
        </td>
      </tr>

  </table>
  <div><br>
  </div>
  <div><br>
  </div>
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</DOCUMENT>
</SEC-DOCUMENT>
