<SEC-DOCUMENT>0000899140-21-000478.txt : 20210503
<SEC-HEADER>0000899140-21-000478.hdr.sgml : 20210503
<ACCEPTANCE-DATETIME>20210503171919
ACCESSION NUMBER:		0000899140-21-000478
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20210503
DATE AS OF CHANGE:		20210503
GROUP MEMBERS:		INNOVIVA STRATEGIC OPPORTUNITIES LLC

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Entasis Therapeutics Holdings Inc.
		CENTRAL INDEX KEY:			0001724344
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				824592913
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90651
		FILM NUMBER:		21884719

	BUSINESS ADDRESS:	
		STREET 1:		35 GATEHOUSE DRIVE
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451
		BUSINESS PHONE:		(781) 810-0120

	MAIL ADDRESS:	
		STREET 1:		35 GATEHOUSE DRIVE
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Entasis Therapeutics Ltd
		DATE OF NAME CHANGE:	20171204

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Innoviva, Inc.
		CENTRAL INDEX KEY:			0001080014
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				943265960
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		1350 OLD BAYSHORE HIGHWAY
		STREET 2:		SUITE 400
		CITY:			BURLINGAME
		STATE:			CA
		ZIP:			94010
		BUSINESS PHONE:		6502389600

	MAIL ADDRESS:	
		STREET 1:		1350 OLD BAYSHORE HIGHWAY
		STREET 2:		SUITE 400
		CITY:			BURLINGAME
		STATE:			CA
		ZIP:			94010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	THERAVANCE INC
		DATE OF NAME CHANGE:	20020207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADVANCED MEDICINE INC
		DATE OF NAME CHANGE:	20000302
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>i050321a.htm
<DESCRIPTION>SCHEDULE 13D (AMENDMENT NO. 4)
<TEXT>
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    <div style="text-align: center; margin-right: 166.6pt; margin-left: 166.9pt; margin-top: 4.45pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; margin-right: 166.6pt; margin-left: 167pt; margin-top: 0.5pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; margin-right: 166.45pt; margin-left: 167pt; margin-top: 2.05pt; font-weight: bold;">Washington, D.C.&#160; 20549</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="margin-top: 0.5pt;"><br>
    </div>
    <div style="text-align: center; margin-right: 166.6pt; margin-left: 166.95pt; font-size: 14pt; font-weight: bold;">SCHEDULE 13D/A</div>
    <div style="text-align: center; margin-right: 178.95pt; margin-left: 179.45pt; margin-top: 1.35pt; font-weight: bold;">Under the Securities Exchange Act of 1934 (Amendment No. 4)*</div>
    <div><br>
    </div>
    <div style="text-align: center; font-size: 14pt; font-weight: bold;">ENTASIS THERAPEUTICS HOLDINGS INC.</div>
    <div style="margin-top: 0.1pt;">
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; margin-right: 166.6pt; margin-left: 166.9pt; margin-top: 1.15pt;">(Name of Issuer)</div>
    <div style="margin-top: 1.15pt;"><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Common Stock, $0.001 par value</div>
    <div style="margin-top: 0.1pt;">
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; margin-right: 166.55pt; margin-left: 167pt; margin-top: 1.15pt;">(Title of Class of Securities)</div>
    <div style="margin-top: 1.15pt;"><br>
    </div>
    <div style="text-align: center; font-weight: bold;">293614 103</div>
    <div style="margin-top: 0.1pt;">
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; margin-right: 166.6pt; margin-left: 166.9pt; margin-top: 1.15pt;">(CUSIP Number)</div>
    <div style="margin-top: 1.15pt;"><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Pavel Raifeld</div>
    <div style="text-align: center; font-weight: bold;">Chief Executive Officer</div>
    <div style="text-align: center; font-weight: bold;">Innoviva, Inc.</div>
    <div style="text-align: center; font-weight: bold;">1350 Old Bayshore Highway Suite 400</div>
    <div style="text-align: center; font-weight: bold;">Burlingame, CA</div>
    <div style="text-align: center; font-weight: bold;">877-202-1097</div>
    <div style="margin-top: 0.1pt;">
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="margin: 1.15pt 0px 0px; font-family: 'Times New Roman',Times,serif; text-align: center;">(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)</div>
    <div style="margin-top: 1.15pt;"><br>
    </div>
    <div style="text-align: center; font-weight: bold;">May 3, 2021</div>
    <div style="margin-top: 0.25pt;">
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="margin: 1.15pt 0px 0px; font-family: 'Times New Roman',Times,serif; text-align: center;">(Date of Event which Requires Filing of this Statement)</div>
    <div style="margin-top: 0.45pt;"><br>
    </div>
    <div style="text-align: justify; margin-right: 60.15pt; margin-left: 59pt;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of
      &#167;&#167;240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#9744;</div>
    <div style="margin-top: 0.45pt;"><br>
    </div>
    <div style="text-align: justify; margin-right: 60.2pt; margin-left: 59pt; margin-top: 4.55pt;"><font style="font-weight: bold;">Note</font>: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all
      exhibits. See &#167;240.13d-7 for other parties to whom copies are to be sent.</div>
    <div><br>
    </div>
    <div style="text-align: justify; margin-right: 60.05pt; margin-left: 58.95pt; margin-top: 0.05pt;"><font style="font-size: 8pt;">* </font>The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with
      respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.</div>
    <div><br>
    </div>
    <div style="text-align: justify; margin-right: 60.15pt; margin-left: 58.95pt; margin-top: 0.05pt;">The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange
      Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
    <div><br>
    </div>
    <div style="margin-top: 0.45pt;"><br>
    </div>
    <div style="margin-right: 117.45pt; margin-left: 86pt; margin-top: 5.75pt; font-weight: bold;">Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB
      control number.</div>
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      <table cellspacing="0" cellpadding="2" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

          <tr>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">1</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">NAME OF REPORTING PERSON</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Innoviva, Inc.<br>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">2</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
              <div style="font-family: 'Times New Roman', Times, serif;">(a) <br>
              </div>
              <div style="font-family: 'Times New Roman', Times, serif;">(b) <br>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">3</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">SEC USE ONLY</div>
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">4</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">SOURCE OF FUNDS</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; WC</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">5</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160; <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">6</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Delaware<br>
              </div>
            </td>
          </tr>
          <tr>
            <td rowspan="4" style="width: 10%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">NUMBER&#160;OF</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">SHARES</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">BENEFICIALLY</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">OWNED&#160;BY</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">EACH</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">REPORTING</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">PERSON</div>
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">WITH</div>
            </td>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">7</div>
            </td>
            <td style="width: 80%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">SOLE VOTING POWER</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br>
                <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; 37,345,794<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">8</div>
            </td>
            <td style="width: 80%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">SHARED VOTING POWER</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; 7,462,050<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">9</div>
            </td>
            <td style="width: 80%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">SOLE DISPOSITIVE POWER</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; 37,345,794<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">10</div>
            </td>
            <td style="width: 80%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">SHARED DISPOSITIVE POWER</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; 7,462,050<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">11</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; 44,807,844<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">12</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160; <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">13</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; 70.6%<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></div>
            </td>
          </tr>
          <tr>
            <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">14</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="font-family: 'Times New Roman', Times, serif;">TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
              <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; CO</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="margin-top: 0.5pt;"><br>
    </div>
    <br>
    <div>
      <div>
        <table cellspacing="0" cellpadding="0" id="z72cc4f9bcac24a16928a93d27923e8b5" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0.5pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 36pt; vertical-align: top; align: right;">
                <div style="margin-left: 18pt; margin-top: 0.5pt;">(1)</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="margin-top: 0.5pt;">Includes shares of Common Stock and warrants to purchase Common Stock acquired by INVA on April 22, 2020, June 11, 2020, and September 1, 2020.</div>
              </td>
            </tr>

        </table>
      </div>
      <div>
        <table cellspacing="0" cellpadding="0" id="zb31079ffe675479cb214abde855f3c6e" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0.5pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 36pt; vertical-align: top; align: right;">
                <div style="margin-left: 18pt; margin-top: 0.5pt;">(2)</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="margin-top: 0.5pt;">Includes shares of Common Stock and warrants to purchase Common Stock acquired by ISO on May 3, 2021.</div>
              </td>
            </tr>

        </table>
        <div>
          <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0.5pt; width: 100%; text-align: left; color: #000000;">

              <tr>
                <td style="width: 36pt; vertical-align: top; align: right;">
                  <div style="margin-left: 18pt; margin-top: 0.5pt;">(3)</div>
                </td>
                <td style="width: auto; vertical-align: top;">
                  <div style="margin-top: 0.5pt;">Based on 37,310,254 shares of Common Stock outstanding as April 16, 2021, as reported by the Issuer in its proxy statement on Schedule 14A filed on April 30, 2021 <u>plus</u> 3,731,025 shares of Common
                    Stock and warrants to purchase 3,731,025 shares of Common Stock acquired by the Reporting Persons on May 3, 2021, <u>plus</u> warrants to purchase 18,672,897 shares of Common Stock previously acquired by the Reporting Persons.&#160; Does
                    not include shares of Common Stock or warrants to purchase Common Stock to be issued by the Issuer upon the closing of the transaction described in Item 4 below.</div>
                </td>
              </tr>

          </table>
        </div>
      </div>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div><br>
      <div>
        <table cellspacing="0" cellpadding="2" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

            <tr>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">1</div>
              </td>
              <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman', Times, serif;">NAME OF REPORTING PERSON</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Innoviva Strategic Opportunities LLC</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">2</div>
              </td>
              <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman', Times, serif;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
                <div style="font-family: 'Times New Roman', Times, serif;">(a) <br>
                </div>
                <div style="font-family: 'Times New Roman', Times, serif;">(b) <br>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">3</div>
              </td>
              <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman', Times, serif;">SEC USE ONLY</div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">4</div>
              </td>
              <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman', Times, serif;">SOURCE OF FUNDS</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; WC</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">5</div>
              </td>
              <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman', Times, serif;">CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160; <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">6</div>
              </td>
              <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman', Times, serif;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Delaware<br>
                </div>
              </td>
            </tr>
            <tr>
              <td rowspan="4" style="width: 10%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">NUMBER&#160;OF</div>
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">SHARES</div>
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">BENEFICIALLY</div>
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">OWNED&#160;BY</div>
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">EACH</div>
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">REPORTING</div>
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">PERSON</div>
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">WITH</div>
              </td>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">7</div>
              </td>
              <td style="width: 80%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman', Times, serif;">SOLE VOTING POWER</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; 0<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"></sup></div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">8</div>
              </td>
              <td style="width: 80%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman', Times, serif;">SHARED VOTING POWER</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; 7,462,050</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">9</div>
              </td>
              <td style="width: 80%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div>
                  <div style="font-family: 'Times New Roman', Times, serif;">SOLE DISPOSITIVE POWER</div>
                  <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
                </div>
                <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; 0 </div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">10</div>
              </td>
              <td style="width: 80%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman', Times, serif;">SHARED DISPOSITIVE POWER</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; 7,462,050</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">11</div>
              </td>
              <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman', Times, serif;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; 7,462,050<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"></sup></div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">12</div>
              </td>
              <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman', Times, serif;">CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160; <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
                <div>&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">13</div>
              </td>
              <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman', Times, serif;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
                <div style="font-family: 'Times New Roman', Times, serif;">11.8%<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
              </td>
            </tr>
            <tr>
              <td style="width: 10%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-weight: bold;">14</div>
              </td>
              <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
                <div style="font-family: 'Times New Roman', Times, serif;">TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
                <div style="font-family: 'Times New Roman', Times, serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; OO</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="margin-top: 0.5pt;"><br>
      </div>
      <div>
        <div><br>
        </div>
        <div>
          <table cellspacing="0" cellpadding="0" id="z043774f8e1a541da8ba8cc2d620eca6d" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0.5pt; width: 100%; text-align: left; color: #000000;">

              <tr>
                <td style="width: 36pt; vertical-align: top; align: right;">
                  <div style="margin-left: 18pt; margin-top: 0.5pt;">(1)</div>
                </td>
                <td style="width: auto; vertical-align: top;">
                  <div style="margin-top: 0.5pt;">Based on 37,310,254 shares of Common Stock outstanding as April 16, 2021, as reported by the Issuer in its proxy statement on Schedule 14A filed on April 30, 2021 <u>plus</u> 3,731,025 shares of Common
                    Stock and warrants to purchase 3,731,025 shares of Common Stock acquired by ISO on May 3, 2021, <u>plus</u> warrants to purchase 18,672,897 shares of Common Stock previously acquired by INVA.&#160; Does not include shares of Common Stock or
                    warrants to purchase Common Stock to be issued by the Issuer upon the second closing of the transaction described in Item 4 below</div>
                </td>
              </tr>

          </table>
        </div>
      </div>
      <div><br>
      </div>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div><br>
    </div>
    <div style="margin-left: 22.4pt; font-weight: bold;">Explanatory Note</div>
    <div style="margin-top: 0.4pt;"><br>
    </div>
    <div style="text-align: justify; margin-right: 23.65pt; margin-left: 36pt; margin-top: 0.05pt;">This Amendment No. 4 (the &#8220;Amendment No. 4&#8221;) amends and supplements the initial Statement of Beneficial Ownership on Schedule 13D, as filed with the
      Securities and Exchange Commission on April 23, 2020 and previously amended, (as amended, the &#8220;Schedule 13D&#8221;) with respect to shares of common stock, $0.001 par value per share (&#8220;Common Stock&#8221;) of Entasis Therapeutics Holdings Inc., a Delaware
      corporation (the &#8220;Issuer&#8221;) and warrants to acquire additional shares of Common Stock of the Issuer. Innoviva, Inc. (&#8220;INVA&#8221;) and Innoviva Strategic Opportunities LLC (&#8220;ISO&#8221; and together with INVA, the &#8220;Reporting Persons&#8221;) are filing this amendment to
      reflect the execution of a Securities Purchase Agreement (as defined below) in respect of the acquisition of additional shares of Common Stock and Common Warrants. Except as specifically amended and supplemented by this Amendment No. 4, the Schedule
      13D remains in full force and effect.</div>
    <div style="margin-top: 0.25pt;"><br>
    </div>
    <div style="margin-left: 23.55pt; margin-top: 0.05pt; font-weight: bold;">Item 2. Identity and Background</div>
    <div style="margin-top: 0.05pt;"><br>
    </div>
    <div style="text-indent: 12.45pt; margin-left: 23.55pt; margin-top: 0.05pt;">Item 2 in Schedule 13D is hereby supplemented as follows:</div>
    <div style="margin-top: 0.05pt;"><br>
    </div>
    <div style="text-indent: 0.3pt; margin-left: 36pt; margin-top: 0.05pt;">Innoviva Strategic Opportunities LLC (&#8220;ISO&#8221;) is a wholly-owned subsidiary of Innoviva which was formed on November 25, 2020.</div>
    <div style="margin-top: 0.05pt;"><br>
    </div>
    <div style="margin-left: 36pt; margin-top: 0.05pt;">The address of the principal business office of ISO is: c/o Innoviva, Inc., 1350 Old Bayshore Highway Suite 400&#160; Burlingame, CA.</div>
    <div style="margin-left: 23.55pt; margin-top: 0.05pt;"> <br>
    </div>
    <div style="margin-left: 36pt; margin-top: 0.05pt;">Neither Reporting Person has been, (a) with respect to INVA, in the last five years, and (b) with respect to ISO, since the date of its formation: (i) convicted in a criminal proceeding, or (ii) a
      party to any other civil proceeding of a judicial or administrative body of competent jurisdiction, as a result of which the Reporting Person is or has been subject to a judgment, decree or final order enjoining future violations of, or prohibiting
      or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.</div>
    <div style="margin-top: 0.05pt;"><br>
    </div>
    <div style="margin-left: 23.55pt; margin-top: 0.05pt; font-weight: bold;">Item 3. Source and Amount of Funds or Other Consideration</div>
    <div style="margin-top: 0.05pt;"><br>
    </div>
    <div>
      <div style="text-align: justify; text-indent: 36pt;">Item 3 of Schedule 13D is hereby supplemented as follows:</div>
    </div>
    <div>
      <div><br>
      </div>
    </div>
    <div>
      <div style="text-align: justify; margin-left: 36pt;">ISO acquired the shares and Common Warrants for an aggregate purchase price of approximately $7.5 million.&#160; The Securities were acquired with funds provided from working capital of the Reporting
        Persons.</div>
    </div>
    <div style="margin-top: 0.05pt;"><br>
    </div>
    <div style="margin-left: 23.55pt; margin-top: 0.05pt; font-weight: bold;">Item 4. Purpose of Transaction</div>
    <div style="margin-left: 36pt; margin-top: 12pt; margin-bottom: 12pt;">Item 4 in Schedule 13D is hereby supplemented as follows:</div>
    <div style="margin-left: 36pt; margin-top: 12pt; margin-bottom: 12pt;">On May 3, 2021, the Issuer entered into a securities purchase agreement (the &#8220;Securities Purchase Agreement&#8221;) with ISO, pursuant to which the Issuer agreed to initially issue and
      sell to ISO (i) 3,731,025 shares of Common Stock (the &#8220;Shares&#8221;), and (ii) warrants to purchase 3,731,025 shares of Common Stock (the &#8220;Common Warrants&#8221;), with each Share and Common Warrant being issued and sold as a unit, for a per unit price of
      $2.00.&#160; In addition to the Shares and Common Warrants referenced in the preceding sentence, ISO may acquire an additional 6,268,975 shares of Common Stock and additional Warrants to purchase 6,268,975 shares of Common Stock of the Issuer, subject to
      satisfaction of certain conditions set forth in the Securities Purchase Agreement, including that the Securities Purchase Agreement and the transactions contemplated thereby having been approved by the stockholders of the Issuer as may be required by
      the applicable rules and regulations of&#160;Nasdaq Stock Market LLC.</div>
    <div style="margin-left: 36pt; margin-top: 12pt; margin-bottom: 12pt;">The exercise price and the number of shares of Common Stock issuable upon exercise of each Common Warrant is subject to appropriate adjustments in the event of certain stock
      dividends and distributions, stock splits, stock combinations, reclassifications or similar events affecting the Common Stock. Each Common Warrant issued to ISO is exercisable from the date of issuance and has a term of five years and an initial
      exercise price of $2.00.</div>
    <div style="margin-left: 36pt; margin-top: 12pt; margin-bottom: 12pt;">The foregoing summaries of the Securities Purchase Agreement and Common Warrants do not purport to be complete and are subject to, and qualified in their entirety by, the full text
      of the Securities Purchase Agreement and the form of Common Warrant, respectively, which are filed as Exhibit 10.1 to the Form 8-K of the Issuer filed with the SEC on May 3, 2021 and are incorporated herein by reference; any description herein of the
      Securities Purchase Agreement is qualified in its entirety by reference to the Securities Purchase Agreement so filed by the Issuer.</div>
    <div style="margin-left: 36pt; margin-top: 12pt; margin-bottom: 12pt;">The Reporting Persons may, from time to time and at any time, either alone or together with others: (i) acquire additional Common Stock and warrants and/or other equity, debt,
      notes, instruments or other securities (collectively, &#8220;Securities&#8221;) of the Issuer in the open market or otherwise&#894; (ii) dispose of any or all of its Securities in the open market or otherwise&#894; or (iii) engage in any hedging or similar transactions
      with respect to the Securities. The Reporting Persons agreed to purchase the Common Stock and Common Warrants reported in this Amendment No. 4 for investment purposes.</div>
    <div style="margin-left: 23.55pt; margin-top: 0.05pt; font-weight: bold;">Item 5. Interest in Securities of the Issuer</div>
    <div style="margin-left: 36pt; margin-top: 12pt; margin-bottom: 12pt;">Item 5 in Schedule 13D is hereby amended and restated as follows:</div>
    <div style="margin-left: 36pt; margin-top: 0.5pt;">The information contained in the cover paged and in Item 4 to this Schedule 13D is hereby incorporated by reference into this Item 5.&#160; The Reporting Persons did not acquire or sell any shares of Common
      Stock or other securities of the Issuer during the last 60 days.</div>
    <div style="margin-top: 0.5pt;"><br>
    </div>
    <div style="margin-left: 23pt; margin-top: 0.05pt; font-weight: bold;">Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer</div>
    <div style="margin-top: 0.4pt;"><br>
    </div>
    <div style="margin-left: 36pt;">Item 6 in Schedule 13D is hereby supplemented as follows:</div>
    <div><br>
    </div>
    <div style="margin-left: 36pt;">The information contained above in Item 4 is hereby incorporated by reference into this Item 6.</div>
    <div style="margin-left: 36pt; margin-top: 12pt; margin-bottom: 12pt;">In connection with the Securities Purchase Agreement, the Issuer entered into a Registration Rights Agreement (the &#8220;Registration Rights Agreement&#8221;) with ISO. Pursuant to the
      Registration Rights Agreement, the Issuer agreed to prepare and file a registration statement with the SEC for purposes of registering the resale of the Shares, the shares of Common Stock issuable upon exercise of the Common Warrants, the Common
      Warrants and any shares of Common Stock issued as a dividend or other distribution with respect to the Shares or shares of Common Stock issuable upon exercise of the Common Warrants.</div>
    <div style="margin-left: 36pt;">The form of Registration Rights Agreement is attached as Exhibit 10.2 to the Form 8-K of the Issuer filed with the SEC on May 3, 2021 and is incorporated by reference in this Schedule 13D; any description herein of the
      Registration Rights Agreement is qualified in its entirety by reference to the Registration Rights Agreement so filed by the Issue.</div>
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    <div style="margin-left: 23pt; margin-top: 3.15pt; font-weight: bold;">Item 7. Material to Be Filed as Exhibits</div>
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    </div>
    <div>
      <div style="font-family: 'Times New Roman',Times,serif; margin-left: 36pt;">Exhibit 9 &#8211; Securities Purchase Agreement, dated as of May 3, 2021, by and between Entasis Therapeutics Holdings Inc. and Innoviva Strategic Opportunities LLC (incorporated
        by reference to Exhibit 10.1 to the Form 8-K of the Issuer filed with the SEC on May 3, 2021)</div>
      <div style="font-family: 'Times New Roman',Times,serif; margin-left: 36pt;"> <br>
      </div>
      <div style="font-family: 'Times New Roman',Times,serif; margin-left: 36pt;">Exhibit 10 &#8211; Registration Rights Agreement, dated as of May 3, 2021, by and between Entasis Therapeutics Holdings Inc. and Innoviva Strategic Opportunities LLC (incorporated
        by reference to Exhibit 10.2 to the Form 8-K of the Issuer filed with the SEC on May 3, 2021)</div>
      <div style="font-family: 'Times New Roman',Times,serif; margin-left: 36pt;"> <br>
      </div>
      <div style="font-family: 'Times New Roman',Times,serif; margin-left: 36pt;">Exhibit 99.1 &#8211; Joint Filing Agreement, dated as of May 3, 2021, by and between the Reporting Persons</div>
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    <div style="text-align: center; margin-left: 23pt; font-weight: bold;">SIGNATURE</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-right: 23.6pt; margin-left: 23pt;">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</div>
    <div><br>
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    <div style="text-align: justify; text-indent: 36pt; margin-right: 23.6pt; margin-left: 23pt;">Dated: May 3, 2021</div>
    <div><br>
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    <div><br>
    </div>
    <div><br>
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    <div style="text-indent: 36pt; margin-right: 23.6pt; margin-left: 23pt;"><font style="font-weight: bold;">INNOVIVA, INC.<br>
      </font><br>
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    <div><br>
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    <div style="text-indent: 36pt; margin-right: 23.6pt; margin-left: 23pt; font-weight: bold;">By:&#160;<u>&#160;&#160; /s/ Pavel Raifeld&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u><br>
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    <div style="margin-right: 23.6pt; margin-left: 36pt; font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Name: Pavel Raifeld</div>
    <div style="margin-right: 23.6pt; margin-left: 36pt; font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Title: Chief Executive Officer</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="margin: 0px 23.6pt 0px 59pt; font-weight: bold;"> INNOVIVA STRATEGIC OPPORTUNITIES LLC<br>
      By: Innoviva, Inc., its managing member<br>
    </div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; margin-right: 23.6pt; margin-left: 23pt; font-weight: bold;">By:&#160;<u>&#160;&#160; /s/ Pavel Raifeld&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u></div>
    <div style="margin-right: 23.6pt; margin-left: 36pt; font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Name: Pavel Raifeld</div>
    <div style="margin-left: 25pt; font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Title: Chief Executive Officer</div>
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<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
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<DESCRIPTION>JOINT FILING AGREEMENT
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    <div style="text-align: right; font-weight: bold;">Exhibit 99.1</div>
    <div style="text-align: center; margin-top: 9pt;"><u>JOINT FILING AGREEMENT</u></div>
    <div style="text-align: justify; text-indent: 36pt; margin-top: 9pt;">The undersigned acknowledge and agree that the foregoing amendment to Schedule 13D is filed on behalf of each of the undersigned and that all subsequent amendments to the Schedule
      13D shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing agreements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness
      and accuracy of the information concerning it contained therein, but shall not be responsible for the completeness and accuracy of the information concerning the others, except to the extent that it knows or has reason to believe that such
      information is inaccurate. This Agreement may be executed in any number of counterparts and all of such counterparts taken together shall constitute one and the same instrument.</div>
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            <div style="font-family: 'Times New Roman', Times, serif;">Dated:&#160; May 3, 2021</div>
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            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">INNOVIVA, INC.</div>
            <div>&#160;</div>
            <div style="text-indent: -17.3pt; margin-left: 17.3pt; font-family: 'Times New Roman', Times, serif;">By: &#160;<u>/s/&#160; Pavel Raifeld&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u><br>
              Name: Pavel Raifeld<br>
              Title: Chief Executive Officer</div>
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            <div style="font-family: 'Times New Roman', Times, serif;">Dated:&#160; May 3, 2021</div>
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            <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold;">INNOVIVA STRATEGIC OPPORTUNITIES LLC</div>
            <div>&#160;</div>
            <div style="text-indent: -17.3pt; margin-left: 17.3pt; font-family: 'Times New Roman', Times, serif;">By: Innoviva, Inc., its managing member</div>
            <div>&#160;</div>
            <div style="text-indent: -17.3pt; margin-left: 17.3pt; font-family: 'Times New Roman', Times, serif;">By: &#160;<u>/s/&#160; Pavel Raifeld&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u><br>
              Name: Pavel Raifeld<br>
              Title: Chief Executive Officer</div>
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