<SEC-DOCUMENT>0001011438-21-000156.txt : 20210525
<SEC-HEADER>0001011438-21-000156.hdr.sgml : 20210525
<ACCEPTANCE-DATETIME>20210525170556
ACCESSION NUMBER:		0001011438-21-000156
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20210525
DATE AS OF CHANGE:		20210525
GROUP MEMBERS:		ALEXANDER J. DENNER, PH.D.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Innoviva, Inc.
		CENTRAL INDEX KEY:			0001080014
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				943265960
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-80415
		FILM NUMBER:		21961593

	BUSINESS ADDRESS:	
		STREET 1:		1350 OLD BAYSHORE HIGHWAY
		STREET 2:		SUITE 400
		CITY:			BURLINGAME
		STATE:			CA
		ZIP:			94010
		BUSINESS PHONE:		6502389600

	MAIL ADDRESS:	
		STREET 1:		1350 OLD BAYSHORE HIGHWAY
		STREET 2:		SUITE 400
		CITY:			BURLINGAME
		STATE:			CA
		ZIP:			94010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	THERAVANCE INC
		DATE OF NAME CHANGE:	20020207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADVANCED MEDICINE INC
		DATE OF NAME CHANGE:	20000302

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sarissa Capital Management LP
		CENTRAL INDEX KEY:			0001577524
		IRS NUMBER:				900924432
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203-302-2330

	MAIL ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>form_sc13da-sarissa.htm
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            <div style="text-align: center; text-indent: -10pt; margin-left: 10pt; font-size: 12pt; font-weight: bold;">UNITED STATES</div>
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            <div style="text-align: center; text-indent: -10pt; margin-left: 10pt; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
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            <div style="text-align: center; text-indent: -10pt; margin-left: 10pt; font-family: 'Times New Roman', serif; font-size: 1pt; font-weight: bold;">&#160;</div>
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            <div style="text-align: center; text-indent: -10pt; margin-left: 10pt; font-size: 12pt; font-weight: bold;">SCHEDULE 13D</div>
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            <div style="font-family: 'Times New Roman', serif; font-size: 1pt; font-weight: bold;">&#160;</div>
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    <div style="text-align: center; font-size: 12pt; font-weight: bold;">Under the Securities Exchange Act of 1934<br>
      (Amendment No.&#160;2)*</div>
    <div style="text-align: center; font-size: 12pt;">&#160;</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-size: 12pt; font-weight: bold;">Innoviva, Inc.</div>
    <div style="text-align: center; font-size: 12pt;">(Name of Issuer)</div>
    <div style="text-align: center; font-size: 12pt;">&#160;</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-size: 12pt; font-weight: bold;">Common Stock, $0.01 par value</div>
    <div style="text-align: center; font-size: 12pt;">(Title of Class of Securities)</div>
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    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-size: 12pt; font-weight: bold;">45781M101</div>
    <div style="text-align: center; font-size: 12pt;">(CUSIP Number)</div>
    <div style="text-align: center; font-size: 12pt;">&#160;</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-size: 12pt; font-weight: bold;">Mark DiPaolo</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-size: 12pt; font-weight: bold;">Senior Partner and General Counsel</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-size: 12pt; font-weight: bold;">Sarissa Capital Management LP</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-size: 12pt; font-weight: bold;">660 Steamboat Road</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-size: 12pt; font-weight: bold;">Greenwich, CT 06830</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-size: 12pt; font-weight: bold;">203-302-2330</div>
    <div style="text-align: center; font-size: 12pt;">(Name, Address and Telephone Number of Person<br>
      Authorized to Receive Notices and Communications)</div>
    <div style="text-align: center; font-size: 12pt;">&#160;</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; font-size: 12pt; font-weight: bold;">May 25, 2021</div>
    <div style="text-align: center;"><font style="font-size: 12pt;">(Date of Event Which Requires Filing of this Statement)<br>
      </font><br>
    </div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of
      Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box. &#9633;</div>
    <div style="margin-top: 5pt; margin-bottom: 5pt; font-family: 'Times New Roman',Times,serif; font-size: 12pt;"><font style="font-weight: bold;">Note</font>: Schedules filed in paper format shall include a signed original and five copies of the
      schedule, including all exhibits. See Rule 13d-7 for other parties to whom copies are to be sent.</div>
    <div style="margin-top: 5pt; margin-bottom: 5pt; font-family: 'Times New Roman',Times,serif; font-size: 12pt;">*&#160;The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class
      of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.</div>
    <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise
      subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
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          <td style="width: 100%; vertical-align: middle;">
            <div style="font-family: 'Times New Roman',Times,serif; font-size: 12pt;">CUSIP No. 45781M101&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160; SCHEDULE 13D</div>
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          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;1&#160;</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">NAME OF REPORTING PERSON OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">Sarissa Capital Management LP</div>
          </td>
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        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;2</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
            <div>&#160;</div>
            <div style="font-size: 12pt;">(a)&#160;&#160;&#9744;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)&#160;&#160;&#9744;</div>
          </td>
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          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;3</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SEC USE ONLY</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div>&#160;</div>
          </td>
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        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;4</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SOURCE OF FUNDS</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">AF</div>
          </td>
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          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;5</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR</div>
            <div style="font-size: 12pt;">2(e)&#160;&#160;&#9744;</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
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        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;6</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">DELAWARE</div>
          </td>
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          <td colspan="3" rowspan="4" style="width: 18.41%; vertical-align: middle; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">NUMBER&#160;OF</div>
            <div style="text-align: center; font-size: 12pt;">SHARES</div>
            <div style="text-align: center; font-size: 12pt;">BENEFICIALLY</div>
            <div style="text-align: center; font-size: 12pt;">OWNED&#160;BY</div>
            <div style="text-align: center; font-size: 12pt;">EACH</div>
            <div style="text-align: center; font-size: 12pt;">REPORTING</div>
            <div style="text-align: center; font-size: 12pt;">PERSON</div>
            <div style="text-align: center; font-size: 12pt;">WITH</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;7&#160;</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 69.88%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SOLE VOTING POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;8</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SHARED&#160;VOTING POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">6,414,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;9</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SOLE DISPOSITIVE POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">0</div>
          </td>
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        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">10</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SHARED&#160;DISPOSITIVE POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">6,414,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">11</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">6,414,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">12</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES&#160;&#160;&#9744;</div>
            <div>&#160;</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">13</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">9.24%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">14</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">TYPE OF REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">PN, IA</div>
          </td>
        </tr>

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          <td style="width: 55.94%; vertical-align: middle;">
            <div style="font-size: 12pt;">CUSIP No. 45781M101&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; SCHEDULE 13D</div>
          </td>
          <td style="width: 44.06%; vertical-align: middle;">
            <div style="text-align: right; font-size: 12pt;">&#160;</div>
          </td>
        </tr>

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    <div><br>
    </div>
    <div style="font-size: 12pt;">&#160;</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="zad49d8ed78914df1b70c4198fa379833">

        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;1&#160;</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">NAME OF REPORTING PERSON OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">Alexander J. Denner, Ph.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;2</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
            <div>&#160;</div>
            <div style="font-size: 12pt;">(a)&#160;&#160;&#9744;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)&#160;&#160;&#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;3</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SEC USE ONLY</div>
            <div>&#160;</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;4</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SOURCE OF FUNDS</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">AF</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;5</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR</div>
            <div style="font-size: 12pt;">2(e)&#160;&#160;&#9744;</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;6</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">UNITED STATES</div>
          </td>
        </tr>
        <tr>
          <td colspan="3" rowspan="4" style="width: 18.41%; vertical-align: middle; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">NUMBER&#160;OF</div>
            <div style="text-align: center; font-size: 12pt;">SHARES</div>
            <div style="text-align: center; font-size: 12pt;">BENEFICIALLY</div>
            <div style="text-align: center; font-size: 12pt;">OWNED&#160;BY</div>
            <div style="text-align: center; font-size: 12pt;">EACH</div>
            <div style="text-align: center; font-size: 12pt;">REPORTING</div>
            <div style="text-align: center; font-size: 12pt;">PERSON</div>
            <div style="text-align: center; font-size: 12pt;">WITH</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;7&#160;</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 69.88%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SOLE VOTING POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;8</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SHARED&#160;VOTING POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">6,414,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;9</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SOLE DISPOSITIVE POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">10</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;&#160;</div>
          </td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">SHARED&#160;DISPOSITIVE POWER</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">6,414,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">11</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">6,414,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">12</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES&#160;&#160;&#9744;</div>
            <div>&#160;</div>
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">13</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">9.24%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">14</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">TYPE OF REPORTING PERSON</div>
            <div style="font-size: 12pt;">&#160;</div>
            <div style="font-size: 12pt;">IN, HC</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after:always;" id="DSPFPageBreak">
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    </div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;">Amendment No. 2 to Schedule 13D</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">The following constitutes Amendment No. 2 to the Schedule 13D filed by the undersigned (&#8220;Amendment No. 2&#8221;).&#160; This Amendment No. 2 amends the Schedule 13D as specifically set forth herein.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">All capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Schedule 13D, as amended. Information given in response to each item shall be deemed incorporated by
      reference in all other items, as applicable.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt; font-weight: bold;">Item 2.&#160; Identity and Background</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Item 2 of the Schedule 13D is hereby amended and restated as follows:</div>
    <div><br>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="font-size: 12pt;">(a) The persons filing this Schedule 13D are Sarissa Capital Management LP, a Delaware limited partnership (&#8220;Sarissa Capital&#8221;) and Alexander J. Denner, Ph.D., a citizen of the United States of America (collectively, the
        &#8220;Reporting Persons&#8221;).</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">The funds and other private investment vehicles (collectively, the &#8220;Sarissa Funds&#8221;), for which Sarissa Capital acts as the investment advisor, directly own the Shares.&#160; Sarissa Capital may be deemed to have beneficial
        ownership over the Shares directly held by the Sarissa Funds by virtue of the authority granted to it to vote and to dispose of the securities held by them, including the Shares held by them.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Dr. Denner is the Chief Investment Officer of Sarissa Capital and the ultimate general partner of Sarissa Capital, accordingly, Dr. Denner may be deemed to have beneficial ownership over the Shares directly held by the
        Sarissa Funds by virtue of such positions.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(b) The principal business address of Sarissa Capital and Dr. Denner is c/o Sarissa Capital Management LP, 660 Steamboat Road, Greenwich, CT 06830.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(c) Sarissa Capital&#8217;s principal business is serving as investment advisor to the Sarissa Funds.&#160; The principal business of each of the Sarissa Funds is making investments. Dr. Denner&#8217;s principal occupation is serving as
        the Chief Investment Officer of Sarissa Capital.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">The name, citizenship, present principal occupation or employment and business address of each director and executive officer of Sarissa Capital is set forth in Schedule A attached hereto.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(d) None of the Reporting Persons, nor, to the best of the Reporting Persons&#8217; knowledge, any manager or executive officer of Sarissa Capital, has, during the past five years, been convicted in a criminal proceeding
        (excluding traffic violations or similar misdemeanors).</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(e) None of the Reporting Persons, nor, to the best of the Reporting Persons&#8217; knowledge, any manager or executive officer of Sarissa Capital, has, during the past five years, been a party to a civil proceeding of a
        judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting, or mandating activities subject to, Federal or State
        securities laws or a finding of any violation with respect to such laws.</div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="page-break-after:always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(f)&#160; Sarissa Capital is a Delaware limited partnership. Dr. Denner is a citizen of the United States of America.</div>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt; font-weight: bold;">Item 4.&#160; Purpose of Transaction</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Item 4 of the Schedule 13D is hereby amended by adding the following:</div>
    <div style="font-size: 12pt;">&#160;</div>
    <div style="font-size: 12pt;">On May 20, 2021, Innoviva, Inc. (the &#8220;Issuer&#8221;) entered into a share repurchase agreement (the &#8220;Share Repurchase Agreement&#8221;) to purchase 32,005,260 Shares from Glaxo Group Limited (&#8220;GSK&#8221;) (the &#8220;Transaction&#8221;), representing
      all of the Shares or other capital interests of the Issuer owned by GSK or its affiliates, for an aggregate purchase price of $392,064,435. The closing of the purchase under the Share Repurchase Agreement occurred on May 25, 2021.&#160; The Reporting
      Persons believe the Shares are undervalued and that the Transaction is in the best interests of all shareholders of the Issuer.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">In order to provide proceeds to the Issuer to fund a portion of the Transaction, Innoviva Strategic Partners LLC (&#8220;Strategic Partners&#8221;), a wholly owned subsidiary of the Issuer, received a distribution of $110,000,000 from
      ISP Fund LP (the &#8220;Partnership&#8221;), in accordance with that certain Letter Agreement, dated May 20, 2021, by and among Strategic Partners, the Partnership and Sarissa Capital Fund GP LP (the &#8220;Letter Agreement&#8221;). Under the terms of the Letter Agreement,
      Strategic Partners has committed to make additional capital contributions to the Partnership in an amount equal to the distribution prior to March 31, 2022.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">The foregoing description of the Letter Agreement does not purport to be complete, and is qualified in its entirety by reference to the full text of the Letter Agreement, which is incorporated by reference as Exhibit 4
      hereto, and is incorporated herein by reference.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt; font-weight: bold;">Item 5.&#160; Interest in Securities of the Issuer</div>
    <div style="font-size: 12pt;">&#160;</div>
    <div style="font-size: 12pt;">Item 5 (a), (b) and (c) of the Schedule 13D are hereby amended and restated as follows:</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">(a)&#160;The Reporting Persons may be deemed to beneficially own, in the aggregate, 6,414,000 Shares representing approximately 9.24% of the Issuer&#8217;s outstanding Shares (based upon 101,408,012 Shares stated to be outstanding as
      of April 19, 2021, by the Issuer in the Issuer&#8217;s Form&#160;10-Q filed with the Securities and Exchange Commission on April 28, 2021, minus the 32,005,260 Shares purchased by the Issuer in the Transaction).</div>
    <div style="font-size: 12pt;">&#160;</div>
    <div style="font-size: 12pt;">(b)&#160;For purposes of this Schedule 13D:</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">All of the Shares for which Sarissa Capital and Dr. Denner may be deemed to have beneficial ownership are held directly by the Sarissa Funds for which Sarissa Capital serves as the investment advisor. Sarissa Capital, as
      the investment advisor to the Sarissa Funds, may be deemed to have the shared power to vote or direct the vote of (and the shared power to dispose or direct the disposition of) the 6,414,000 Shares held by the Sarissa Funds.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="font-size: 12pt;">By virtue of his position as the Chief Investment Officer of Sarissa Capital and as the managing member of Sarissa Capital&#8217;s general partner, Dr.&#160;Denner may be deemed to have the shared power to vote or direct the vote of
      (and the shared power to dispose or direct the disposition of) the 6,414,000 Shares held by the Sarissa Funds.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">(c)&#160; The Reporting Persons did not transact in the Shares in the past 60 days.</div>
    <div style="font-size: 12pt;">&#160;</div>
    <div style="font-size: 12pt;"><font style="font-weight: bold;">Item 7.&#160; Material to be Filed as Exhibits</font><br>
    </div>
    <br>
    <div>
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 9%; vertical-align: top;">
              <div style="font-size: 12pt;">Exhibit 4 <br>
              </div>
            </td>
            <td style="width: 91%; vertical-align: top;">
              <div style="font-size: 12pt;">Letter Agreement, by and among Innoviva Strategic Partners LLC, ISP Fund LP and Sarissa Capital Fund GP LP, dated May 20, 2021 (incorporated by reference to Exhibit 10.2 to the Issuer&#8217;s Current Report on Form
                8-K, filed with the SEC on May 20, 2021).</div>
              <div>&#160;</div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
    <br>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after:always;" id="DSPFPageBreak">
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    </div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;">SIGNATURE</div>
    <div style="font-size: 12pt;">&#160;</div>
    <div style="text-indent: 36pt; font-size: 12pt;">After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this statement is true, complete and correct.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Dated: May 25, 2021</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="zb48fae4e9cd4401fbf97d37639c49f71">

        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top;">
            <div style="font-size: 12pt;">SARISSA CAPITAL MANAGEMENT LP</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.68%; vertical-align: top;">
            <div style="font-size: 12pt;">By:</div>
          </td>
          <td style="width: 91.32%; vertical-align: top;">
            <div style="font-size: 12pt;"><u>/s/ Mark DiPaolo</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.68%; vertical-align: top;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 91.32%; vertical-align: top;">
            <div style="font-size: 12pt;">Name: Mark DiPaolo</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.68%; vertical-align: top;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 91.32%; vertical-align: top;">
            <div style="font-size: 12pt;">Title: General Counsel</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top;">
            <div style="font-size: 12pt;"><u>/s/Alexander J. Denner</u></div>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top;">
            <div style="font-size: 12pt;">Alexander J. Denner</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="zfe7335c33caa4daba65914e5bd23acfc">

        <tr>
          <td style="width: 100%; vertical-align: top;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
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    <div style="text-align: center; font-size: 12pt;"><u>SCHEDULE A</u></div>
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    <div style="text-align: center; font-size: 12pt;">DIRECTORS AND EXECUTIVE OFFICERS OF THE REPORTING PERSONS</div>
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    <div style="font-size: 12pt;">The following sets forth the name, position, and principal occupation of each director and executive officer of each of the Reporting Persons. Each such person is a citizen of the United States of America. Except as
      otherwise indicated, the business address of each director and officer is c/o Sarissa Capital Management LP, 660 Steamboat Road, Greenwich, CT 06830. To the best of the Reporting Persons' knowledge, except as set forth in this statement on Schedule
      13D, none of the directors or executive officers of the Reporting Persons own any Shares.</div>
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        <tr>
          <td style="width: 50%; vertical-align: top; border-bottom: 2px solid black;">
            <div style="font-size: 12pt; font-weight: bold;">Name</div>
          </td>
          <td style="width: 50%; vertical-align: top; border-bottom: 2px solid black;">
            <div style="font-size: 12pt; font-weight: bold;">Position</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="font-size: 12pt;">&#160;</div>
          </td>
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          <td style="width: 50%; vertical-align: top;">
            <div style="font-size: 12pt;">Alexander J. Denner, Ph.D.</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="font-size: 12pt;">Chief Investment Officer of Sarissa Capital</div>
          </td>
        </tr>
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          <td style="width: 50%; vertical-align: top;">
            <div style="font-size: 12pt;">Mark DiPaolo</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="font-size: 12pt;">Senior Partner and General Counsel of Sarissa Capital</div>
          </td>
        </tr>
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          <td style="width: 50%; vertical-align: top;">
            <div style="font-size: 12pt;">Patrice Bonfiglio</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="font-size: 12pt;">Chief Financial Officer and Chief Compliance Officer of Sarissa Capital</div>
          </td>
        </tr>
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          <td style="width: 50%; vertical-align: top;">
            <div style="font-size: 12pt;">Eric Vincent</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="font-size: 12pt;">President of Sarissa Capital</div>
          </td>
        </tr>

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