<SEC-DOCUMENT>0000899140-21-000532.txt : 20210614
<SEC-HEADER>0000899140-21-000532.hdr.sgml : 20210614
<ACCEPTANCE-DATETIME>20210611173748
ACCESSION NUMBER:		0000899140-21-000532
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20210614
DATE AS OF CHANGE:		20210611
GROUP MEMBERS:		INNOVIVA STRATEGIC OPPORTUNITIES LLC

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Entasis Therapeutics Holdings Inc.
		CENTRAL INDEX KEY:			0001724344
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				824592913
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90651
		FILM NUMBER:		211012474

	BUSINESS ADDRESS:	
		STREET 1:		35 GATEHOUSE DRIVE
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451
		BUSINESS PHONE:		(781) 810-0120

	MAIL ADDRESS:	
		STREET 1:		35 GATEHOUSE DRIVE
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Entasis Therapeutics Ltd
		DATE OF NAME CHANGE:	20171204

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Innoviva, Inc.
		CENTRAL INDEX KEY:			0001080014
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				943265960
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		1350 OLD BAYSHORE HIGHWAY
		STREET 2:		SUITE 400
		CITY:			BURLINGAME
		STATE:			CA
		ZIP:			94010
		BUSINESS PHONE:		6502389600

	MAIL ADDRESS:	
		STREET 1:		1350 OLD BAYSHORE HIGHWAY
		STREET 2:		SUITE 400
		CITY:			BURLINGAME
		STATE:			CA
		ZIP:			94010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	THERAVANCE INC
		DATE OF NAME CHANGE:	20020207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADVANCED MEDICINE INC
		DATE OF NAME CHANGE:	20000302
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>i43593240.htm
<DESCRIPTION>SCHEDULE 13D/A, AMENDMENT #5
<TEXT>
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      <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-size: 12pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; margin-bottom: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
    <div style="text-align: center; margin-bottom: 12pt; font-size: 12pt; font-weight: bold;"><font style="font-size: 14pt;">SCHEDULE 13D</font><br>
      (Amendment No. 5)*</div>
    <div style="text-align: center; margin-bottom: 18pt; font-size: 12pt; font-weight: bold;">Under the Securities Exchange Act of 1934</div>
    <table cellspacing="0" cellpadding="0" id="z6ba4828c0f38484c9e90c97c5831fbf3" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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            <div style="text-align: center; font-size: 12pt; font-weight: bold;">ENTASIS THERAPEUTICS HOLDINGS INC.</div>
          </td>
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        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">(Name of Issuer)</div>
          </td>
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    </div>
    <div style="margin-top: 3pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="ze11e3330242c4d01a7b987260931c37a" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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          <td style="width: 100%; vertical-align: middle;">
            <div style="text-align: center; font-size: 12pt; font-weight: bold;">Common Stock, $0.001 par value</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">(Title of Class of Securities)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="margin-top: 3pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z48fbab7456994b59b3dbe3239a1159f6" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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          <td style="width: 100%; vertical-align: middle;">
            <div style="text-align: center; font-size: 12pt; font-weight: bold;">293614 103</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">(CUSIP Number)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z5f4417f623154655bebae54b94b088f7" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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          <td style="width: 100%; vertical-align: middle;">
            <div style="text-align: center; font-size: 12pt; font-weight: bold;">Pavel Raifeld</div>
            <div style="text-align: center; font-size: 12pt; font-weight: bold;">Chief Executive Officer</div>
            <div style="text-align: center; font-size: 12pt; font-weight: bold;">Innoviva, Inc.</div>
            <div style="text-align: center; font-size: 12pt; font-weight: bold;">1350 Old Bayshore Highway Suite 400</div>
            <div style="text-align: center; font-size: 12pt; font-weight: bold;">Burlingame, CA</div>
            <div style="text-align: center; font-size: 12pt; font-weight: bold;">877-202-1097</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="margin-top: 9pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z9980c59158c141b680c05728a5ff3cce" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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          <td style="width: 100%; vertical-align: middle;">
            <div style="text-align: center; font-size: 12pt; font-weight: bold;">June 11, 2021</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top; border-top: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">(Date of Event which Requires Filing of this Statement)</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 12pt; margin-bottom: 12pt;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of &#167;&#167;240.13d-1(e),
      240.13d-1(f) or 240.13d-1(g), check the following box:&#160;&#160;&#9723;</div>
    <div style="margin-bottom: 9pt;"><font style="font-weight: bold;">Note:</font>&#160;&#160;Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 240.13d-7 for other parties to whom copies
      are to be sent.</div>
    <table cellspacing="0" cellpadding="0" id="z913d237db9b8479c8da25fa7ab8d1db0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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          <td style="width: 1.07%; vertical-align: top;">
            <div>*</div>
          </td>
          <td style="width: 0.95%; vertical-align: top;">
            <div>&#160;</div>
          </td>
          <td style="width: 97.98%; vertical-align: top;">
            <div>The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter
              disclosures provided in a prior cover page.</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 9pt;">The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 (the &#8220;Act&#8221;) or otherwise subject to the liabilities of
      that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
    <div style="margin-top: 9pt;">
      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"> </div>
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        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div>CUSIP NO. <font style="font-size: 12pt;">04216R 102</font></div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="za22e5f9bf9444e4f86069ae060edeadb" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

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          <td style="width: 20.31%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">1</div>
          </td>
          <td style="width: 79.69%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>NAME OF REPORTING PERSON</div>
            <div>&#160;</div>
            <div style="font-size: 12pt;"><u>Innoviva, Inc.</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.31%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">2</div>
          </td>
          <td style="width: 79.69%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
            <div>(a)&#160;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
            <div>(b)&#160;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.31%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">3</div>
          </td>
          <td style="width: 79.69%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>SEC USE ONLY</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.31%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">4</div>
          </td>
          <td style="width: 79.69%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>SOURCE OF FUNDS</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;WC</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.31%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">5</div>
          </td>
          <td style="width: 79.69%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160; <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.31%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">6</div>
          </td>
          <td style="width: 79.69%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Delaware</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.31%; vertical-align: middle; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" rowspan="4">
            <div style="text-align: center;">NUMBER&#160;OF</div>
            <div style="text-align: center;">SHARES</div>
            <div style="text-align: center;">BENEFICIALLY</div>
            <div style="text-align: center;">OWNED&#160;BY</div>
            <div style="text-align: center;">EACH</div>
            <div style="text-align: center;">REPORTING</div>
            <div style="text-align: center;">PERSON</div>
            <div style="text-align: center;">WITH</div>
          </td>
          <td style="width: 10.17%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">7</div>
          </td>
          <td style="width: 69.52%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>SOLE VOTING POWER</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-size: 12pt;">37,345,794</font><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.17%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">8</div>
          </td>
          <td style="width: 69.52%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>SHARED VOTING POWER</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;20,000,000<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.17%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">9</div>
          </td>
          <td style="width: 69.52%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>SOLE DISPOSITIVE POWER</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-size: 12pt;">37,345,794</font><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.17%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">10</div>
          </td>
          <td style="width: 69.52%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>SHARED DISPOSITIVE POWER</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;20,000,000<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.31%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">11</div>
          </td>
          <td style="width: 79.69%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;57,345,794</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.31%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">12</div>
          </td>
          <td style="width: 79.69%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160; <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.31%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">13</div>
          </td>
          <td style="width: 79.69%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;75.5%<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.31%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">14</div>
          </td>
          <td style="width: 79.69%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;CO</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="z50d9778a03404eb6a628419d264d61fe" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0.5pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; margin-top: 0.5pt; font-family: 'Times New Roman',Times,serif;">(1)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="margin-top: 0.5pt; font-family: 'Times New Roman',Times,serif;">Includes shares of Common Stock and warrants to purchase Common Stock acquired by INVA on April 22, 2020, June 11, 2020, and September 1, 2020.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="zaea9d37042034293a7da07e1d44378c5" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0.5pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; margin-top: 0.5pt; font-family: 'Times New Roman',Times,serif;">(2)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="margin-top: 0.5pt; font-family: 'Times New Roman',Times,serif;">Includes shares of Common Stock and warrants to purchase Common Stock acquired by ISO on May 3, 2021 and June 11, 2021.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="z6d01b9fecd444c8c9b00add247e117f9" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0.5pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; margin-top: 0.5pt; font-family: 'Times New Roman',Times,serif;">(3)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="margin-top: 0.5pt; font-family: 'Times New Roman',Times,serif;">Based on 37,310,254 shares of Common Stock outstanding as of April 27, 2021, as reported by the Issuer in its proxy statement on Schedule 14A filed on May 17, 2021 <u>plus</u>
                6,268,975 shares of Common Stock and warrants to purchase 6,268,975 shares of Common Stock acquired by the Reporting Persons on June 11, 2021 <u>plus</u> 3,731,025 shares of Common Stock and warrants to purchase 3,731,025 shares of Common
                Stock acquired by the Reporting Persons on May 3, 2021, <u>plus</u> warrants to purchase 18,672,897 shares of Common Stock previously acquired by the Reporting Persons.</div>
            </td>
          </tr>

      </table>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div><br>
    </div>
    <div>CUSIP NO. <font style="font-size: 12pt;">04216R 102</font></div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z7728e5623f5a43588bb5960b752134a5" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 20.3%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">1</div>
          </td>
          <td style="width: 79.7%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>NAME OF REPORTING PERSON</div>
            <div>&#160;</div>
            <div style="font-size: 12pt;"><u>Innoviva Strategic Opportunities LLC</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.3%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">2</div>
          </td>
          <td style="width: 79.7%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
            <div>(a)&#160;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
            <div>(b)&#160;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.3%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">3</div>
          </td>
          <td style="width: 79.7%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>SEC USE ONLY</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.3%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">4</div>
          </td>
          <td style="width: 79.7%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>SOURCE OF FUNDS</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;WC</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.3%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">5</div>
          </td>
          <td style="width: 79.7%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160; <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.3%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">6</div>
          </td>
          <td style="width: 79.7%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Delaware</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.3%; vertical-align: middle; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" rowspan="4">
            <div style="text-align: center;">NUMBER&#160;OF</div>
            <div style="text-align: center;">SHARES</div>
            <div style="text-align: center;">BENEFICIALLY</div>
            <div style="text-align: center;">OWNED&#160;BY</div>
            <div style="text-align: center;">EACH</div>
            <div style="text-align: center;">REPORTING</div>
            <div style="text-align: center;">PERSON</div>
            <div style="text-align: center;">WITH</div>
          </td>
          <td style="width: 10.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">7</div>
          </td>
          <td style="width: 69.52%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>SOLE VOTING POWER</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-size: 12pt;">0</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">8</div>
          </td>
          <td style="width: 69.52%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>SHARED VOTING POWER</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;20,000,000<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">9</div>
          </td>
          <td style="width: 69.52%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>SOLE DISPOSITIVE POWER</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-size: 12pt;">0</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">10</div>
          </td>
          <td style="width: 69.52%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>SHARED DISPOSITIVE POWER</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;20,000,000<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.3%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">11</div>
          </td>
          <td style="width: 79.7%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;20,000,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.3%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">12</div>
          </td>
          <td style="width: 79.7%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160; <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.3%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">13</div>
          </td>
          <td style="width: 79.7%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; 34.9%<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
          </td>
        </tr>
        <tr>
          <td style="width: 20.3%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-weight: bold;">14</div>
          </td>
          <td style="width: 79.7%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div>TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</div>
            <div>&#160;</div>
            <div>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;OO</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="zbe1dd41a7e4c43049a766d9e0a146c02" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0.5pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; margin-top: 0.5pt; font-family: 'Times New Roman',Times,serif;">(1)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="margin-top: 0.5pt; font-family: 'Times New Roman',Times,serif;">Includes shares of Common Stock and warrants to purchase Common Stock acquired by ISO on May 3, 2021 and June 11, 2021.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="z9138ae7513bf4f4ca83e499468483db4" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0.5pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; margin-top: 0.5pt; font-family: 'Times New Roman',Times,serif;">(2)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="margin-top: 0.5pt; font-family: 'Times New Roman',Times,serif;">Based on 37,310,254 shares of Common Stock outstanding as of April 27, 2021, as reported by the Issuer in its proxy statement on Schedule 14A filed on May 17, 2021 <u>plus</u>
                6,268,975 shares of Common Stock and warrants to purchase 6,268,975 shares of Common Stock acquired by the Reporting Persons on June 11, 2021 <u>plus</u> 3,731,025 shares of Common Stock and warrants to purchase 3,731,025 shares of Common
                Stock acquired by the Reporting Persons on May 3, 2021.</div>
            </td>
          </tr>

      </table>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="font-weight: bold;">Explanatory Note</div>
    <div>
      <div><br>
      </div>
    </div>
    <div style="text-align: justify; margin-bottom: 6pt;">This Amendment No. 5 (the &#8220;Amendment No. 5&#8221;) amends and supplements the initial Statement of Beneficial Ownership on Schedule 13D, as filed with the Securities and Exchange Commission on April 23,
      2020 and previously amended, (as amended, the &#8220;Schedule 13D&#8221;) with respect to shares of common stock, $0.001 par value per share (&#8220;Common Stock&#8221;) of Entasis Therapeutics Holdings Inc., a Delaware corporation (the &#8220;Issuer&#8221;) and warrants to acquire
      additional shares of Common Stock of the Issuer. Innoviva, Inc. (&#8220;INVA&#8221;) and Innoviva Strategic Opportunities LLC (&#8220;ISO&#8221; and together with INVA, the &#8220;Reporting Persons&#8221;) are filing this amendment to reflect the acquisition of additional shares of
      Common Stock and Common Warrants. Except as specifically amended and supplemented by this Amendment No. 5, the Schedule 13D remains in full force and effect</div>
    <div style="text-align: justify; margin-bottom: 6pt; font-weight: bold;">Item&#160;3. Source and Amount of Funds or Other Consideration</div>
    <div style="margin-bottom: 12pt;">Item 3 of Schedule 13D is hereby supplemented as follows:</div>
    <div style="text-align: justify; margin-bottom: 12pt;">ISO acquired the Securities (as defined below) for an aggregate purchase price of approximately $12.5 million.&#160; The Securities were acquired with funds provided from working capital of the
      Reporting Persons.</div>
    <div style="text-align: justify; margin-bottom: 6pt; font-weight: bold;">Item&#160;4. Purpose of Transaction</div>
    <div style="margin-bottom: 12pt;">As previously disclosed on the Schedule 13D, on May 3, 2021, ISO entered into that certain Securities Purchase Agreement with the Issuer (the &#8220;Purchase Agreement&#8221;), pursuant to which the Issuer agreed to issue and sell
      to ISO, in a private placement, up to 10,000,000 newly issued shares of Common Stock and Warrants to purchase up to 10,000,000 shares of Common Stock, with an exercise price per share of $2.00.</div>
    <div style="margin-bottom: 12pt;">On May 3, 2021 and in connection with the first closing under the Purchase Agreement, the Issuer issued to ISO 3,731,025 shares of Common Stock and Warrants to acquire an additional 3,731,025 shares of Common Stock of
      the Issuer (the &#8220;First Issuance&#8221;).</div>
    <div style="margin-bottom: 12pt;">At a special meeting of stockholders held on June 10, 2021 (the &#8220;Special Meeting&#8221;), the Issuer's stockholders approved the issuance of the shares of Common Stock and Warrants to ISO in the second tranche of the private
      placement. On June 11, 2021, the Issuer issued to ISO 6,268,975 shares of Common Stock and Warrants to acquire an additional 6,268,975 shares of Common Stock of the Issuer (the &#8220;Second Issuance&#8221;). The Warrants, at an exercise price per share of
      $2.00, are exercisable immediately and have a five year term. Each share of Common Stock and Warrant (together, a &#8220;Common Unit&#8221;) have been issued and sold together at price per Common Unit of $2.00.</div>
    <div style="text-align: justify; margin-bottom: 12pt;">ISO purchased the Common Stock and Warrants reported in this Amendment No. 5 for investment purposes.</div>
    <div style="text-align: justify; margin-bottom: 6pt; font-weight: bold;">Item&#160;5. Interest in Securities of the Issuer</div>
    <div style="text-align: justify; margin-bottom: 12pt;">Item 5 in Schedule 13D is hereby amended and restated as follows:</div>
    <div style="text-align: justify; margin-bottom: 12pt;">The information contained in the cover paged and in Item 4 to this Schedule 13D is hereby incorporated by reference into this Item 5.&#160; The Reporting Persons did not acquire or sell any shares of
      Common Stock or other securities of the Issuer during the last 60 days.</div>
    <br>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
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    </div>
    <div style="text-align: center; margin-bottom: 12pt;">SIGNATURES</div>
    <div style="text-align: justify; margin-bottom: 12pt;">After reasonable inquiry and to the best of each of the undersigned&#8217;s knowledge and belief, each of the undersigned, severally and not jointly, certifies that the information set forth in this
      statement is true, complete and correct.</div>
    <div style="margin-bottom: 12pt;">Dated:&#160; June 11, 2021</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="text-indent: 36pt; margin-right: 23.6pt; margin-left: 23pt;"><font style="font-weight: normal;">INNOVIVA, INC.<br>
      </font><font style="font-weight: normal;"><br>
      </font> </div>
    <font style="font-weight: normal;"> </font>
    <div><font style="font-weight: normal;"><br>
      </font> </div>
    <font style="font-weight: normal;"> </font>
    <div style="text-indent: 36pt; margin-right: 23.6pt; margin-left: 23pt; font-weight: bold;"><font style="font-weight: normal;">By:&#160;<u>&#160;&#160; /s/ Pavel Raifeld&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u><br>
      </font> </div>
    <font style="font-weight: normal;"> </font>
    <div style="margin-right: 23.6pt; margin-left: 36pt; font-weight: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Name: Pavel Raifeld</div>
    <font style="font-weight: normal;"> </font>
    <div style="margin-right: 23.6pt; margin-left: 36pt; font-weight: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Title: Chief Executive Officer</div>
    <font style="font-weight: normal;"> </font>
    <div><font style="font-weight: normal;"><br>
      </font> </div>
    <font style="font-weight: normal;"> </font>
    <div><font style="font-weight: normal;"><br>
      </font> </div>
    <font style="font-weight: normal;"> </font>
    <div><font style="font-weight: normal;"><br>
      </font> </div>
    <font style="font-weight: normal;"> </font>
    <div style="margin: 0px 23.6pt 0px 59pt; font-weight: bold;"><font style="font-weight: normal;"> INNOVIVA STRATEGIC OPPORTUNITIES LLC<br>
        By: Innoviva, Inc., its managing member<br>
      </font> </div>
    <font style="font-weight: normal;"> </font>
    <div><font style="font-weight: normal;"><br>
      </font> </div>
    <font style="font-weight: normal;"> </font>
    <div><font style="font-weight: normal;"><br>
      </font> </div>
    <font style="font-weight: normal;"> </font>
    <div style="text-indent: 36pt; margin-right: 23.6pt; margin-left: 23pt; font-weight: normal;">By:&#160;<u>&#160;&#160; /s/ Pavel Raifeld&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u></div>
    <font style="font-weight: normal;"> </font>
    <div style="margin-right: 23.6pt; margin-left: 36pt; font-weight: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Name: Pavel Raifeld</div>
    <font style="font-weight: normal;"> </font>
    <div style="margin-left: 25pt; font-weight: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Title: Chief Executive Officer</div>
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</SEC-DOCUMENT>
