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CONSOLIDATED STATEMENTS OF INCOME - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Revenue: |  |  |
Total net revenue | $ 391,866 | $ 336,794 | $ 261,016
Operating expenses: |  |  |
Research and development | 576 | 1,788 | 0
General and administrative | 16,187 | 13,883 | 14,656
Total operating expenses | 16,763 | 15,671 | 14,656
Income from operations | 375,103 | 321,123 | 246,360
Interest and dividend income | 1,839 | 1,524 | 5,540
Other expense, net | (3,626) | (348) | (345)
Interest expense | (19,070) | (18,331) | (18,660)
Realized gain on equity investments | 91,030 | 50,277 | 0
Income before income taxes | 445,276 | 354,245 | 232,895
Income tax expense, net | 76,439 | 60,431 | 41,902
Net income | 368,837 | 293,814 | 190,993
Net income attributable to noncontrolling interest | 102,983 | 69,412 | 33,705
Net income attributable to Innoviva stockholders | $ 265,854 | $ 224,402 | $ 157,288
Basic net income per share attributable to Innoviva stockholders | $ 3.24 | $ 2.21 | $ 1.55
Diluted net income per share attributable to Innoviva stockholders | $ 2.87 | $ 2.02 | $ 1.43
Shares used to compute Innoviva basic and diluted net income per share: |  |  |
Shares used to compute basic net income per share | 82,062 | 101,320 | 101,150
Shares used to compute diluted net income per share | 94,310 | 113,554 | 113,409
Royalty revenue from a related party |  |  |
Revenue: |  |  |
Total net revenue | $ 391,866 | $ 326,794 | $ 261,016
Revenue from collaborative arrangements |  |  |
Revenue: |  |  |
Total net revenue | $ 0 | $ 10,000 | $ 0

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