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FINANCIAL INSTRUMENTS AND FAIR VALUE MEASUREMENTS - Fair Value Measurements (Details) - USD ($) $ in Thousands | Dec. 11, 2020 | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | --- | ---
ISP Fund LP |  |  |
Debt |  |  |
Lock-up period | 36 months |  |
Money market funds | ISP Fund LP |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | $ 3,500 | $ 284,800
Equity investment | ISP Fund LP |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 192,200 | 14,500
Recurring basis |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 606,792 | 627,254
Recurring basis | Money market funds |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 145,132 | 204,808
Recurring basis | Equity investments and Money market funds | ISP Fund LP |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 195,745 | 299,288
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 489,704 | 576,176
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Money market funds |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 145,132 | 204,808
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investments and Money market funds | ISP Fund LP |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 193,677 | 299,288
Recurring basis | Significant Other Observable Inputs, Level 2 |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 99,509 | 49,931
Recurring basis | Significant Other Observable Inputs, Level 2 | Money market funds |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 0 | 0
Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investments and Money market funds | ISP Fund LP |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 0 | 0
Recurring basis | Significant Unobservable Inputs, Level 3 |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 17,579 | 1,147
Recurring basis | Significant Unobservable Inputs, Level 3 | Money market funds |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 0 | 0
Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investments and Money market funds | ISP Fund LP |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 2,068 | 0
Nonrecurring basis | Debt |  |  |
Debt |  |  |
2023 Notes |  | 261,769 | 239,779
2025 Notes |  | 234,498 | 206,135
Total fair value of debt |  | 496,267 | 445,914
Nonrecurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Debt |  |  |
Debt |  |  |
2023 Notes |  | 0 | 0
2025 Notes |  | 0 | 0
Total fair value of debt |  | 0 | 0
Nonrecurring basis | Significant Other Observable Inputs, Level 2 | Debt |  |  |
Debt |  |  |
2023 Notes |  | 261,769 | 239,779
2025 Notes |  | 234,498 | 206,135
Total fair value of debt |  | 496,267 | 445,914
Nonrecurring basis | Significant Unobservable Inputs, Level 3 | Debt |  |  |
Debt |  |  |
2023 Notes |  | 0 | 0
2025 Notes |  | 0 | 0
Total fair value of debt |  | 0 | 0
Armata | Recurring basis | Equity investment | Common stock |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 88,101 | 25,958
Armata | Recurring basis | Equity investment | Warrants |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 58,595 | 18,049
Armata | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Common stock |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 88,101 | 25,958
Armata | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Warrants |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 0 | 0
Armata | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Common stock |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 0 | 0
Armata | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 58,595 | 18,049
Armata | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Common stock |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 0 | 0
Armata | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Warrants |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 0 | 0
Entasis | Recurring basis | Equity investment | Common stock |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 62,794 | 46,122
Entasis | Recurring basis | Equity investment | Warrants |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 40,914 | 31,882
Entasis | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Common stock |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 62,794 | 46,122
Entasis | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Warrants |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 0 | 0
Entasis | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Common stock |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 0 |
Entasis | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 40,914 | 31,882
Entasis | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Common stock |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 0 | 0
Entasis | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Warrants |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 0 | 0
InCarda | Recurring basis | Equity investment | Warrants |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 411 | 1,147
InCarda | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Warrants |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 0 | 0
InCarda | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 0 | 0
InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Warrants |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 411 | $ 1,147
Gate Neurosciences | Recurring basis | Convertible debt investment |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | 15,100 |
Gate Neurosciences | Recurring basis | Significant Unobservable Inputs, Level 3 | Convertible debt investment |  |  |
Assets |  |  |
Total assets measured at estimated fair value |  | $ 15,100 |

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