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v3.22.1

CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2022 | Mar. 31, 2021
Cash flows from operating activities |  |
Net income | $ 37,858 | $ 109,695
Adjustments to reconcile net income to net cash provided by operating activities: |  |
Deferred income tax | 6,860 | 19,736
Depreciation and amortization | 3,501 | 3,460
Stock-based compensation | 954 | 451
Amortization of debt discount and issuance costs | 377 | 2,211
Changes in fair values of equity and long-term investments, net | 9,411 | (54,673)
Loss on extinguishment of debt | 20,662 | 0
Other | 280 | 8
Changes in operating assets and liabilities: |  |
Receivables from collaborative arrangements | 17,196 | 4,957
Prepaid expenses | 1,345 | 243
Other assets, current | 99 | 328
Accounts payable | 198 | (52)
Accrued personnel-related expenses and other accrued liabilities | 2,116 | 227
Accrued interest payable | (2,755) | (2,484)
Net cash provided by operating activities | 98,102 | 84,107
Cash flows from investing activities |  |
Purchases of equity and long term investments | (56,217) | (26,394)
Purchases of equity investments managed by ISP Fund LP | (2,015) | (112,587)
Sale of equity investments managed by ISP Fund LP | 24,281 | 2,387
Purchase and sales of other investments managed by ISP Fund LP, net | (132,266) | 110,200
Purchases of property and equipment | (9) | 0
Cash acquired through the consolidation of Entasis Therapeutics Holdings, Inc. | 23,070 | 0
Net cash used in investing activities | (143,156) | (26,394)
Cash flows from financing activities |  |
Distributions to noncontrolling interest | (6,507) | (21,285)
Repurchase of shares to satisfy tax withholding | (46) | (25)
Proceeds from issuances of common stock, net | 260 | 0
Payment for repurchase of convertible subordinated notes due 2023 | (165,131) | 0
Purchases of capped call options associated with convertible senior notes due 2028 | (21,037) | 0
Proceeds from issuance of convertible senior notes due 2028, net of issuance costs | 252,792 | 0
Net cash provided by (used in) financing activities | 60,331 | (21,310)
Net increase (decrease) in cash and cash equivalents | 15,277 | 36,403
Cash and cash equivalents at beginning of period | 201,525 | 246,487
Cash and cash equivalents at end of period | 216,802 | 282,890
Supplemental disclosure of cash flow information |  |
Cash paid for interest | 5,411 | 4,967
Supplemental disclosure of non-cash investing and financing activities |  |
Right-of-use asset obtained through the consolidation of Entasis Therapeutics Holdings, Inc | 3,289 | 0
ASU 2020-06 |  |
Supplemental disclosure of non-cash investing and financing activities |  |
Adoption of ASU 2020-06 | $ 28,123 | $ 0

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