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Financial Instruments and Fair Value Measurements - Convertible Promissory Note in Gate Neuroscience (Details) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2022 | Dec. 31, 2021
Equity Investment |  |
Equity and long-term investments | $ 544,437 | $ 483,845
Gate Neuroscience Member |  |
Equity Investment |  |
Number Of Common Stock Issued Description |  | The number of common stock shares to be issued in a qualified event shall be equal to the amount due on the conversion date divided by the lesser of a capped conversion price (the “Capped Conversion Price”) and the qualified event price (the “Qualified Event Price”). The Capped Conversion Price is calculated as $50.0 million divided by the number of shares of common stock outstanding at such time on a fully diluted basis. The Qualified Event Price is the price per share determined by the qualified event. A qualified financing is a sale or series of sales of preferred stock where (i) at least 50 percent of counterparties are not existing shareholders, (ii) net proceeds to Gate are at least $35.0 million, and (iii) the stated or implied equity valuation of Gate is at least $80.0 million. Shadow Preferred means preferred stock having identical rights, preferences and restrictions as the preferred stock that would be issued in a qualified financing.
Equity and long-term investments | 14,900 | $ 15,100
Unrealized loss from fair value changes in equity investments | $ 200 |
Convertible Promissory Note Purchase Agreement | Gate Neuroscience Member |  |
Equity Investment |  |
Convertable notes Face Value |  | $ 15,000
Debt Instrument, Interest Rate, Effective Percentage |  | 8.00%

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