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Financial Instruments and Fair Value Measurements - Schedule of Available-for-Sale Securities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands | 6 Months Ended | 12 Months Ended
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Jun. 30, 2022 | Dec. 31, 2021
ISP Fund LP |  |  |  |
Assets |  |  |  |
Lock-up period | 36 months |  | 36 months |
Contributed to partnership for investing | $ 300,000 |  |  |
Cash | ISP Fund LP |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 70,000 |  |  |
Money market funds | ISP Fund LP |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 35,300 |  | $ 3,500 |
Equity investment | ISP Fund LP |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 201,600 |  | 192,200 |
Private Placement Positions | ISP Fund LP |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 2,100 |  |  |
Recurring basis |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 630,370 |  | 606,792 |
Recurring basis | Money market funds |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 156,460 |  | 145,132 |
Recurring basis | Equity investments and money market funds | ISP Fund LP |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 306,863 | [1] | 195,745 | [2]
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 558,819 |  | 489,704 |
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Money market funds |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 156,460 |  | 145,132 |
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investments and money market funds | ISP Fund LP |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 304,810 | [1] | 193,677 | [2]
Recurring basis | Significant Other Observable Inputs, Level 2 |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 47,148 |  | 99,509 |
Recurring basis | Significant Unobservable Inputs, Level 3 |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 24,403 |  | 17,579 |
Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investments and money market funds | ISP Fund LP |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 2,053 | [1] | 2,068 | [2]
Nonrecurring basis | Debt |  |  |  |
Fair Value Measurements |  |  |  |
2023 Notes | 95,606 |  | 261,769 |
2025 Notes | 214,443 |  | 234,498 |
2028 Notes | 225,530 |  |  |
Total fair value of debt | 535,579 |  | 496,267 |
Nonrecurring basis | Significant Other Observable Inputs, Level 2 | Debt |  |  |  |
Fair Value Measurements |  |  |  |
2023 Notes | 95,606 |  | 261,769 |
2025 Notes | 214,443 |  | 234,498 |
2028 Notes | 225,530 |  |  |
Total fair value of debt | 535,579 |  | 496,267 |
Armata | Recurring basis | Equity investment | Common stock |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 97,549 |  | 88,101 |
Armata | Recurring basis | Equity investment | Warrants |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 47,148 |  | 58,595 |
Armata | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Common stock |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 97,549 |  | 88,101 |
Armata | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 47,148 |  | 58,595 |
Entasis Therapeutics Holdings Inc | Recurring basis | Equity investment | Common stock |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value |  |  | 62,794 |
Entasis Therapeutics Holdings Inc | Recurring basis | Equity investment | Warrants |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value |  |  | 40,914 |
Entasis Therapeutics Holdings Inc | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Common stock |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value |  |  | 62,794 |
Entasis Therapeutics Holdings Inc | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value |  |  | 40,914 |
InCarda | Recurring basis | Equity investment | Warrants |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value |  |  | 411 |
InCarda | Recurring basis | Equity investment | Series C preferred stock |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 6,808 |  |  |
InCarda | Recurring basis | Equity investment | Preferred Stock Warrants |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 342 |  |  |
InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Warrants |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value |  |  | 411 |
InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Series C preferred stock |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 6,808 |  |  |
InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Preferred Stock Warrants |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 342 |  |  |
Gate Neuroscience Member | Recurring basis | Convertible Debt Member |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | 15,200 |  | 15,100 |
Gate Neuroscience Member | Recurring basis | Significant Unobservable Inputs, Level 3 | Convertible Debt Member |  |  |  |
Assets |  |  |  |
Total assets measured at estimated fair value | $ 15,200 |  | $ 15,100 |
[1] | The investments held by ISP Fund LP, consisted of $201.6 million in equity investments, which included a private placement position of $2.1 million, $35.3 million in money market funds and $70.0 million in cash. Our total capital contribution of $300.0 million is subject to a 36-month lock-up period from the date of such capital contributions.
[2] | The investments held by ISP Fund LP, consisted of $192.2 million equity investments and $3.5 million money market funds, are subject to a 36-month lock-up period from our initial contribution date, December 11, 2020.

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