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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2022 | Jun. 30, 2021
Cash flows from operating activities |  |
Net income | $ 59,229 | $ 220,541
Adjustments to reconcile net income to net cash provided by operating activities: |  |
Deferred income tax | 5,984 | 45,069
Depreciation and amortization | 7,092 | 6,918
Stock-based compensation | 2,304 | 921
Amortization of debt discount and issuance costs | 931 | 4,472
Changes in fair values of equity and long-term investments, net | 68,011 | (99,046)
Loss on extinguishment of debt | 20,662 | 0
Other | 857 | 16
Changes in operating assets and liabilities: |  |
Receivables from collaborative arrangements | (965) | (10,331)
Prepaid expenses | 2,968 | 578
Other assets, current | 910 | 328
Other assets, non-current | (844) | 0
Accounts payable | 2,713 | (36)
Accrued personnel-related expenses and other accrued liabilities | 6,939 | (709)
Accrued interest payable | 346 | 0
Net cash provided by operating activities | 177,137 | 168,721
Cash flows from investing activities |  |
Purchases of equity and long term investments | (58,726) | (46,373)
Purchases of equity investments managed by ISP Fund LP | (38,026) | (142,636)
Sale of equity investments managed by ISP Fund LP | 24,281 | 18,545
Purchase and sales of other investments managed by ISP Fund LP, net | (96,255) | 234,091
Purchases of property and equipment | (22) | 0
Cash acquired through the consolidation of Entasis Therapeutics Holdings, Inc. | 23,070 | 0
Net cash provided by (used in) investing activities | (145,678) | 63,627
Cash flows from financing activities |  |
Distributions to noncontrolling interest | (16,054) | (41,446)
Repurchase of common stock | 0 | (394,149)
Repurchase of shares to satisfy tax withholding | (59) | (35)
Proceeds from issuances of common stock, net | 341 | 60
Payment for repurchase of convertible subordinated notes due 2023 | (165,131) | 0
Purchases of capped call options associated with convertible senior notes due 2028 | (21,037) | 0
Proceeds from issuance of convertible senior notes due 2028, net of issuance costs | 252,536 | 0
Net cash provided by (used in) financing activities | 50,596 | (435,570)
Net increase (decrease) in cash and cash equivalents | 82,055 | (203,222)
Cash and cash equivalents at beginning of period | 201,525 | 246,487
Cash and cash equivalents at end of period | 283,580 | 43,265
Supplemental disclosure of cash flow information |  |
Cash paid for interest | 5,411 | 4,967
Supplemental disclosure of non-cash investing and financing activities |  |
Right-of-use asset obtained through the consolidation of Entasis Therapeutics Holdings, Inc. | 3,289 | 0
ASU 2020-06 |  |
Supplemental disclosure of non-cash investing and financing activities |  |
Adoption of ASU 2020-06 | $ 28,123 | $ 0

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