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Description of Operations and Summary of Significant Accounting Policies (Details) - USD ($) $ in Thousands | 6 Months Ended |
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Jun. 30, 2022 | Jun. 30, 2021 | Dec. 31, 2021
Description of Operations and Summary of Significant Accounting Policies |  |  |
Decrease to accumulated deficit | $ 37,200 |  |
Reduction to Additional Paid in Capital | 65,400 |  |
Equity and long-term investments | 494,097 |  | $ 483,845
Purchases of equity investments managed by ISP Fund LP | (38,026) | $ (142,636) |
Sale of equity investments managed by ISP Fund LP | 24,281 | 18,545 |
Purchase and sales of other investments managed by ISP Fund LP, net | 96,255 | (234,091) |
Increase in Deferred Tax Assets | 7,400 |  |
Prior Period Immaterial Correction |  |  |
Description of Operations and Summary of Significant Accounting Policies |  |  |
Purchases of equity investments managed by ISP Fund LP |  | (142,600) |
Sale of equity investments managed by ISP Fund LP |  | 18,500 |
Purchase and sales of other investments managed by ISP Fund LP, net |  | $ 234,100 |
Convertible senior notes |  |  |
Description of Operations and Summary of Significant Accounting Policies |  |  |
Increase in convertible notes | $ 35,600 |  |
Long-Acting Beta2 Agonist (LABA) Collaboration | GSK |  |  |
Description of Operations and Summary of Significant Accounting Policies |  |  |
Percentage of economic interest in any future payments made under the agreements | 15.00% |  |
Long-Acting Beta2 Agonist (LABA) Collaboration | GSK | RELVAR/BREO |  |  |
Description of Operations and Summary of Significant Accounting Policies |  |  |
Royalty rate for first level of annual global net sales (as a percent) | 15.00% |  |
Annual global sales level used to determine royalty rate | $ 3,000,000 |  |
Royalty rate for sales above first level of annual global net sales (as a percent) | 5.00% |  |
Long-Acting Beta2 Agonist (LABA) Collaboration | GSK | ANORO | Minimum |  |  |
Description of Operations and Summary of Significant Accounting Policies |  |  |
Royalty rate for combination products (as a percent) | 6.50% |  |
Long-Acting Beta2 Agonist (LABA) Collaboration | GSK | ANORO | Maximum |  |  |
Description of Operations and Summary of Significant Accounting Policies |  |  |
Royalty rate for combination products (as a percent) | 10.00% |  |

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