<SEC-DOCUMENT>0001140361-22-025754.txt : 20220711
<SEC-HEADER>0001140361-22-025754.hdr.sgml : 20220711
<ACCEPTANCE-DATETIME>20220711172719
ACCESSION NUMBER:		0001140361-22-025754
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20220711
DATE AS OF CHANGE:		20220711
GROUP MEMBERS:		INNOVIVA STRATEGIC OPPORTUNITIES LLC

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Entasis Therapeutics Holdings Inc.
		CENTRAL INDEX KEY:			0001724344
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				824592913
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90651
		FILM NUMBER:		221077750

	BUSINESS ADDRESS:	
		STREET 1:		35 GATEHOUSE DRIVE
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451
		BUSINESS PHONE:		(781) 810-0120

	MAIL ADDRESS:	
		STREET 1:		35 GATEHOUSE DRIVE
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Entasis Therapeutics Ltd
		DATE OF NAME CHANGE:	20171204

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Innoviva, Inc.
		CENTRAL INDEX KEY:			0001080014
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				943265960
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		1350 OLD BAYSHORE HIGHWAY
		STREET 2:		SUITE 400
		CITY:			BURLINGAME
		STATE:			CA
		ZIP:			94010
		BUSINESS PHONE:		6502389600

	MAIL ADDRESS:	
		STREET 1:		1350 OLD BAYSHORE HIGHWAY
		STREET 2:		SUITE 400
		CITY:			BURLINGAME
		STATE:			CA
		ZIP:			94010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	THERAVANCE INC
		DATE OF NAME CHANGE:	20020207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADVANCED MEDICINE INC
		DATE OF NAME CHANGE:	20000302
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>ny20004305x13_sc13da.htm
<DESCRIPTION>SC 13D/A
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Financial Solutions, Inc.
         Document created using EDGARfilings PROfile 8.4.0.0
         Copyright 1995 - 2022 Broadridge -->
  </head>
<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <hr style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center">
    <div><br>
    </div>
    <div>
      <div style="text-align: center; color: #000000; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; color: #000000; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; color: #000000; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-size: 18pt; font-weight: bold;">SCHEDULE 13D/A</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">(Amendment No. 10)*</div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Under the Securities Exchange Act of 1934</div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-size: 24pt; font-weight: bold;">ENTASIS THERAPEUTICS HOLDINGS INC.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">
        <div>
          <hr style="height: 1px; width: 25%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
        (Name of Issuer)</div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Common Stock, par value $0.001 per share</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">
        <div>
          <hr style="height: 1px; width: 25%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
        (Title of Class of Securities)</div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">293614 103</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">
        <div>
          <hr style="height: 1px; width: 25%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
        (CUSIP Number)</div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Pavel Raifeld</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Chief Executive Officer</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Innoviva, Inc.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">1350 Old Bayshore Highway Suite 400</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Burlingame, CA</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">877-202-1097</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">
        <div>
          <hr style="height: 1px; width: 25%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
        (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)</div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">July 7, 2022</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">
        <div>
          <hr style="height: 1px; width: 25%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
        (Date of Event which Requires Filing of this Statement)</div>
      <div><br>
      </div>
      <div style="color: #000000;"> <br>
      </div>
      <div style="color: #000000;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of &#167;&#167;240.13d-1(e), 240.13d-1(f) or
        240.13d-1(g), check the following box:&#8195;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
      <div><br>
      </div>
      <div style="color: #000000;"><font style="font-weight: bold;">Note:</font>&#8195;Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 240.13d-7 for other parties to whom copies
        are to be sent.</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z3328a1b6ee41483cbf88f6f779de3333" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 2%; vertical-align: top;">
              <div style="color: #000000;">*</div>
            </td>
            <td style="width: 98%; vertical-align: top;">
              <div style="color: #000000;">The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information
                which would alter disclosures provided in a prior cover page.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="color: #000000;">The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 (the &#8220;Act&#8221;) or otherwise subject to the liabilities of
        that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div>
        <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
      </div>
      <!--PROfilePageNumberReset%Num%2%- % -%-->
      <div style="color: #000000;">CUSIP NO. 04216R 102</div>
      <div style="color: #000000;"> <br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z4699f362d5ab4e6bad6185506ba9640b" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">1</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">NAME OF REPORTING PERSON</div>
              <div style="color: #000000;">&#8195;<u>Innoviva, Inc.</u></div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">2</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
              <div style="color: #000000;">&#8195;(a) <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
              <div style="color: #000000;">&#8195;(b) <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">3</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">SEC USE ONLY</div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">4</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">SOURCE OF FUNDS</div>
              <div style="color: #000000;">&#8195;WC</div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">5</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)&#8195;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">6</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
              <div style="color: #000000;">&#8195;Delaware</div>
            </td>
          </tr>
          <tr>
            <td rowspan="4" style="width: 12%; vertical-align: middle; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000;">NUMBER OF</div>
              <div style="text-align: center; color: #000000;">SHARES</div>
              <div style="text-align: center; color: #000000;">BENEFICIALLY</div>
              <div style="text-align: center; color: #000000;">OWNED BY</div>
              <div style="text-align: center; color: #000000;">EACH</div>
              <div style="text-align: center; color: #000000;">REPORTING</div>
              <div style="text-align: center; color: #000000;">PERSON</div>
              <div style="text-align: center; color: #000000;">WITH</div>
            </td>
            <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">7</div>
            </td>
            <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">SOLE VOTING POWER</div>
              <div style="color: #000000;">&#8195;100</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">8</div>
            </td>
            <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">SHARED VOTING POWER</div>
              <div style="color: #000000;">&#8195;0</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">9</div>
            </td>
            <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">SOLE DISPOSITIVE POWER</div>
              <div style="color: #000000;">&#8195;100</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">10</div>
            </td>
            <td style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">SHARED DISPOSITIVE POWER</div>
              <div style="color: #000000;">&#8195;0</div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">11</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
              <div style="color: #000000;">&#8195;100</div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">12</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)&#8195;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">13</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
              <div style="color: #000000;">&#8195;100%</div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">14</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</div>
              <div style="color: #000000;">&#8195;CO</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">- 2 -</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
      </div>
      <div><br>
      </div>
      <div style="color: #000000;">CUSIP NO. 04216R 102</div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z9e74566ce79240fab74ff49e9878000c" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">1</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">NAME OF REPORTING PERSON</div>
              <div style="color: #000000;">&#8195;<u>Innoviva Strategic Opportunities LLC</u></div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">2</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
              <div style="color: #000000;">&#8195;(a) <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
              <div style="color: #000000;">&#8195;(b) <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">3</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">SEC USE ONLY</div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">4</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">SOURCE OF FUNDS</div>
              <div style="color: #000000;">&#8195;WC</div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">5</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)&#8195;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">6</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
              <div style="color: #000000;">&#8195;Delaware</div>
            </td>
          </tr>
          <tr>
            <td rowspan="4" style="width: 12%; vertical-align: middle; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000;">NUMBER OF</div>
              <div style="text-align: center; color: #000000;">SHARES</div>
              <div style="text-align: center; color: #000000;">BENEFICIALLY</div>
              <div style="text-align: center; color: #000000;">OWNED BY</div>
              <div style="text-align: center; color: #000000;">EACH</div>
              <div style="text-align: center; color: #000000;">REPORTING</div>
              <div style="text-align: center; color: #000000;">PERSON</div>
              <div style="text-align: center; color: #000000;">WITH</div>
            </td>
            <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">7</div>
            </td>
            <td style="width: 60%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">SOLE VOTING POWER</div>
              <div style="color: #000000;">&#8195;0</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">8</div>
            </td>
            <td style="width: 60%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">SHARED VOTING POWER</div>
              <div style="color: #000000;">&#8195;0</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">9</div>
            </td>
            <td style="width: 60%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">SOLE DISPOSITIVE POWER</div>
              <div style="color: #000000;">&#8195;0</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">10</div>
            </td>
            <td style="width: 60%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">SHARED DISPOSITIVE POWER</div>
              <div style="color: #000000;">&#8195;0</div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">11</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
              <div style="color: #000000;">&#8195;0</div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">12</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)&#8195;<font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">13</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
              <div style="color: #000000;">&#8195;0%</div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="text-align: center; color: #000000; font-weight: bold;">14</div>
            </td>
            <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="color: #000000;">TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</div>
              <div style="color: #000000;">&#8195;OO</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">- 3 -</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
      </div>
      <div><br>
      </div>
      <div style="color: #000000; font-weight: bold;">Explanatory Note</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">This Amendment No. 10 (the &#8220;Amendment No. 10&#8221;) amends and supplements the initial Statement of Beneficial Ownership on Schedule 13D, as filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on
        April 23, 2020 and previously amended (as amended, the &#8220;Schedule 13D&#8221;), with respect to shares of common stock, par value $0.001 per share (&#8220;Common Stock&#8221;), of Entasis Therapeutics Holdings Inc., a Delaware corporation (&#8220;Entasis&#8221; or the &#8220;Issuer&#8221;),
        and warrants to acquire additional shares of Common Stock of the Issuer. Innoviva, Inc. (&#8220;INVA&#8221;), a Delaware corporation, and Innoviva Strategic Opportunities LLC (&#8220;ISO&#8221;) are together referred to herein as the &#8220;Reporting Persons&#8221;. Except as
        specifically amended and supplemented by this Amendment No. 10, the Schedule 13D remains in full force and effect.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">On July 11, 2022, INVA and Innoviva Merger Sub, Inc. (&#8220;Purchaser&#8221;), a Delaware corporation and a wholly owned subsidiary of INVA, consummated the transactions contemplated by that certain Agreement
        and Plan of Merger, dated May 23, 2022, by and among Entasis, INVA, and Purchaser (as amended, restated, supplemented or otherwise modified from time to time, the &#8220;Merger Agreement&#8221;). Pursuant to the terms of the Merger Agreement, Purchaser merged
        with and into Entasis (the &#8220;Merger&#8221;), with Entasis continuing as the surviving corporation and a wholly owned subsidiary of INVA.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">Pursuant to the Merger Agreement, INVA and Purchaser conducted a tender offer (the &#8220;Offer&#8221;) for any and all of the outstanding shares of Common Stock, other than shares of Common Stock owned by INVA
        and its affiliates, at a price of $2.20 per share of Common Stock (the &#8220;Offer Price&#8221;). The Offer expired at 5:00 p.m., New York City time, on July 7, 2022 (the &#8220;Expiration Time&#8221;). Computershare Trust Company, N.A., in its capacity as depositary for
        the Offer advised INVA and Purchaser that, as of the Expiration Time, a total of 11,671,662 shares of Common Stock were validly tendered and not validly withdrawn pursuant to the Offer, which represented approximately 24.34% of the shares of Common
        Stock outstanding as of the Expiration Time, and, excluding the 56,072 Shares tendered by Manoussos Perros (the Chief Executive Officer of Entasis), represented approximately 60.45% of the shares of Common Stock not beneficially owned by Purchaser,
        INVA or Mr. Perros as of the Expiration Time.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">As of the Expiration Time, the number of shares of Common Stock validly tendered and not validly withdrawn pursuant to the Offer satisfied the minimum tender condition to the Offer and all other
        conditions to the Offer were satisfied or waived. Promptly after the Expiration Time, Purchaser irrevocably accepted for payment, and expects to promptly pay for, all shares of Common Stock validly tendered and not validly withdrawn pursuant to the
        Offer. As a result of its acceptance of the shares of Common Stock tendered in the Offer (together with the shares of Common Stock owned by INVA and its wholly owned subsidiaries prior to the commencement of the Offer), Purchaser acquired
        sufficient shares of Common Stock to complete the Merger without the affirmative vote of the stockholders of Entasis pursuant to Section 251(h) of the General Corporation Law of the State of Delaware (the &#8220;DGCL&#8221;).</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z089fce91a0b14d3aaac7fbe78f31a5e2" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="color: #000000; font-weight: bold;">Item 4.</div>
            </td>
            <td style="width: 94%; vertical-align: top;">
              <div style="color: #000000; font-weight: bold;">Purpose of Transaction.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">Item 4 in Schedule 13D is hereby amended and supplemented to include the following:</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">On July 11, 2022, pursuant to the terms of the Merger Agreement, Purchaser merged with and into Entasis, with Entasis continuing as the surviving corporation and a wholly owned subsidiary of INVA.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">Concurrently with the consummation of the Merger (the &#8220;Effective Time&#8221;), each share of Common Stock issued and outstanding immediately prior to the Effective Time, not including any shares of Common
        Stock (i) owned or held in the treasury of Entasis, (ii) owned by INVA and Purchaser or (iii) owned by stockholders who are entitled to appraisal rights under the DGCL and who have complied with all provisions thereof concerning the exercise of
        such appraisal rights, were automatically converted into the right to receive an amount in cash equal to the Offer Price, subject to reduction for any applicable withholding taxes and without interest.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">At the Effective Time, the 100 shares of common stock, par value $0.01 per share of Purchaser that were issued and outstanding immediately prior to the Effective Time were automatically converted into
        100 shares of common stock, par value $0.01 per share of Entasis.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">Promptly following the Effective Time, Entasis shall cause the shares of Common Stock to be delisted from the Nasdaq Global Market and deregistered under the Securities Exchange Act of 1934, as
        amended.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">Except as set forth herein and in connection with the Offer and the Merger described above, the Reporting Persons have no plan or proposal that relates to or would result in any of the transactions
        described in subparagraphs (a) through (j) of Item 4 of Schedule 13D.</div>
      <div><br>
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">- 4 -</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
      </div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zd3e50d10b3ef4a25815c72c5e79d8e2b" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="color: #000000; font-weight: bold;">Item 5.</div>
            </td>
            <td style="width: 94%; vertical-align: top;">
              <div style="color: #000000; font-weight: bold;">Interest in the Securities of the Issuer.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">Item 5 in Schedule 13D is hereby amended and restated as follows:</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;"><font style="font-weight: bold;">(a)-(b)</font>&#8195;The beneficial ownership percentages described in this Amendment No. 10 are based on a total of 100 shares of common stock, par value $0.01 per share of
        Entasis outstanding as of July 11, 2022.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">The information contained on the cover pages to this Amendment No. 10 is incorporated herein by reference. The shares of common stock reported on this Amendment No. 10 are directly held by INVA. The
        total issued and outstanding shares of common stock held by INVA comprises 100% of the issued and outstanding shares of common stock of Entasis.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">Except for the shares of common stock of Entasis owned by INVA, none of the Reporting Persons or, to the knowledge of the Reporting Persons, any of the other persons listed on Schedule I hereto
        beneficially owns any other securities of Entasis.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;"><font style="font-weight: bold;">(c)</font>&#8195;Except for the Merger Agreement and the transactions described in this Amendment No. 10, neither the Reporting Persons nor, to the knowledge of the
        Reporting Persons, any person listed on Schedule I hereto, have effected any transactions in the shares of common stock of Entasis during the past 60 days.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;"><font style="font-weight: bold;">(d)</font>&#8195;To the knowledge of the Reporting Persons, no other person has the right to receive or the power to direct the receipt of dividends from, or the proceeds
        from the sale of, the securities covered by this Amendment No. 10.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;"><font style="font-weight: bold;">(e)</font>&#8195;Not applicable.</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z3a6b578d21364bc2822785f44d855032" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="color: #000000; font-weight: bold;">Item 6.</div>
            </td>
            <td style="width: 94%; vertical-align: top;">
              <div style="color: #000000; font-weight: bold;">Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">Item 6 in the Schedule 13D is hereby supplemented by adding the following:</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">The information set forth in Item 4 hereof is incorporated herein by reference.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">The Reporting Persons also entered into that certain Termination Agreement, dated as of July 11, 2022, by and among INVA, ISO, and Entasis (the &#8220;Termination Agreement&#8221;), pursuant to which the
        following agreements were terminated: (i) Registration Rights Agreement, dated April 22, 2020, by and between Entasis and INVA; (ii) Registration Rights Agreement, dated May 3, 2021, by and between Entasis and ISO; and (iii) Registration Rights
        Agreement, dated February 18, 2022, by and between Entasis and ISO.</div>
      <div><br>
      </div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zca2cd861fcfe403ba38eddd5556dc3d1" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="color: #000000; font-weight: bold;">Item 7.</div>
            </td>
            <td style="width: 94%; vertical-align: top;">
              <div style="color: #000000; font-weight: bold;">Material to be Filed as Exhibits.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zb1a62099b6aa40fc96929b52b70140ba" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 6%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap">
              <div style="text-align: center; color: #000000; font-weight: bold;">Exhibit</div>
              <div>
                <div style="text-align: center; color: #000000; font-weight: bold;">No.</div>
              </div>
            </td>
            <td style="width: 6%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);" nowrap="nowrap">
              <div>
                <div style="text-align: center; color: #000000; font-weight: bold;">Description</div>
              </div>
            </td>
          </tr>
          <tr>
            <td rowspan="1" style="width: 6%; vertical-align: top;" nowrap="nowrap">&#160;</td>
            <td rowspan="1" style="width: 6%; vertical-align: bottom;">&#160;</td>
            <td rowspan="1" style="width: 88%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;" nowrap="nowrap">
              <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1080014/000089914021000478/i050321b.htm">99.1</a></div>
            </td>
            <td style="width: 6%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88%; vertical-align: top;">
              <div style="color: #000000;">Joint Filing Agreement, dated May 3, 2021, between the Reporting Persons (incorporated by reference to Exhibit 99.1 to the 13D/A No. 4 filed by the Reporting Persons with the SEC on May 3, 2021).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;" nowrap="nowrap">
              <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1080014/000114036122025608/ny20004305x10_exa5f.htm">Exhibit 21</a></div>
            </td>
            <td style="width: 6%; vertical-align: top; text-align: center;">&#8212;<br>
            </td>
            <td style="width: 88%; vertical-align: top;">
              <div style="color: #000000;">Press release issued by INVA on July 8, 2022 (incorporated by reference to Exhibit (a)(5)(F) to the Schedule TO/A No. 2 filed by INVA and Purchaser with the SEC on July 8, 2022).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;" nowrap="nowrap">
              <div style="color: #000000;">Exhibit 22</div>
            </td>
            <td style="width: 6%; vertical-align: top; text-align: center;">&#160;&#8212;</td>
            <td style="width: 88%; vertical-align: top;">
              <div style="color: #000000;">Press release issued by INVA on July 11, 2022 (incorporated by reference to Exhibit 99.2 to the Current Report filed by INVA with the SEC on July 11, 2022).</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">- 5 -</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
      </div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000;">SIGNATURES</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">After reasonable inquiry and to the best of each of the undersigned&#8217;s knowledge and belief, each of the undersigned, severally and not jointly, certifies that the information set forth in this
        statement is true, complete and correct.</div>
      <div><br>
      </div>
      <div style="color: #000000;">Dated:&#8195;July 11, 2022</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="za335985db95549a4b0443fbdcd1682d4" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
            <td style="width: 80%; vertical-align: top;">
              <div style="color: #000000;">INNOVIVA, INC.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
            <td style="width: 80%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
            <td style="width: 80%; vertical-align: top;">
              <div style="color: #000000;">By:&#8195;<u>/s/ Pavel Raifeld</u></div>
              <div style="color: #000000;">Name:&#8195;Pavel Raifeld</div>
              <div style="color: #000000;">Title:&#8195;Chief Executive Officer</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
            <td style="width: 80%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
            <td style="width: 80%; vertical-align: top;">
              <div style="color: #000000;">INNOVIVA STRATEGIC OPPORTUNITIES LLC</div>
              <div style="color: #000000;">By:&#8195;Innoviva, Inc., its managing member</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
            <td style="width: 80%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
            <td style="width: 80%; vertical-align: top;">
              <div style="color: #000000;">By:&#8195;<u>/s/ Pavel Raifeld</u></div>
              <div style="color: #000000;">Name:&#8195;Pavel Raifeld</div>
              <div style="color: #000000;">Title:&#8195;Chief Executive Officer</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">- 6 -</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
      </div>
      <!--PROfilePageNumberReset%Num%7%- % -%-->
      <div><br>
      </div>
      <div>
        <div style="text-align: center; color: #000000; font-weight: bold;">SCHEDULE I</div>
        <div><br>
        </div>
      </div>
      <div>
        <div style="text-align: justify; color: #000000;">The following information is set forth below with respect to each executive officer and director of INVA: name, business address, position with INVA and present principal occupation or employment
          and, for persons not employed by INVA, the name, principal business and address of any corporation or other organization in which such employment is conducted.</div>
        <div><br>
        </div>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zb56fca84d78d4c78b98d81051d621b1b" border="0" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: #000000; font-weight: bold;">Name</div>
            </td>
            <td style="width: 9.64%; vertical-align: top; border-bottom: #000000 2px solid;">
              <div style="color: #000000; font-weight: bold;">Business Address</div>
            </td>
            <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: #000000; font-weight: bold;">Position with</div>
              <div style="color: #000000; font-weight: bold;">Reporting Person</div>
            </td>
            <td style="width: 35%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: #000000; font-weight: bold;">Present Principal Occupation or Employment</div>
            </td>
            <td style="width: 15%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: #000000; font-weight: bold;">Citizenship</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: #000000; font-weight: bold;">Directors</div>
            </td>
            <td style="width: 9.64%; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
            <td style="width: 35%; vertical-align: top;">&#160;</td>
            <td style="width: 15%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">George W. Bickerstaff, III</div>
            </td>
            <td style="width: 9.64%; vertical-align: top;">
              <div style="color: #000000;">(1)</div>
            </td>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Director</div>
            </td>
            <td style="width: 35%; vertical-align: top;">
              <div style="color: #000000;">Managing Director of M.M. Dillon</div>
              <div style="color: #000000;">&amp; Co., LLC (2)</div>
            </td>
            <td style="width: 15%; vertical-align: top;">
              <div style="color: #000000;">United States</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Deborah L. Birx, M.D.</div>
            </td>
            <td style="width: 9.64%; vertical-align: top;">
              <div style="color: #000000;">(1)</div>
            </td>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Director</div>
            </td>
            <td style="width: 35%; vertical-align: top;">
              <div style="color: #000000;">Chief Medical and Science Advisor of</div>
              <div style="color: #000000;">ActivePure (3)</div>
            </td>
            <td style="width: 15%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Mark DiPaolo</div>
            </td>
            <td style="width: 9.64%; vertical-align: top;">
              <div style="color: #000000;">(1)</div>
            </td>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Director</div>
            </td>
            <td style="width: 35%; vertical-align: top;">
              <div style="color: #000000;">Partner and the General Counsel of</div>
              <div style="color: #000000;">Sarissa Capital Management LP (4)</div>
            </td>
            <td style="width: 15%; vertical-align: top;">
              <div style="color: #000000;">United States</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Jules Haimovitz</div>
            </td>
            <td style="width: 9.64%; vertical-align: top;">
              <div style="color: #000000;">(1)</div>
            </td>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Director</div>
            </td>
            <td style="width: 35%; vertical-align: top;">
              <div style="color: #000000;">President of Haimovitz Consulting,</div>
              <div style="color: #000000;">Inc. (5)</div>
            </td>
            <td style="width: 15%; vertical-align: top;">
              <div style="color: #000000;">United States</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Odysseas D. Kostas</div>
            </td>
            <td style="width: 9.64%; vertical-align: top;">
              <div style="color: #000000;">(1)</div>
            </td>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Director</div>
            </td>
            <td style="width: 35%; vertical-align: top;">
              <div style="color: #000000;">Partner and Senior Analyst at</div>
              <div style="color: #000000;">Sarissa Capital Management LP (4)</div>
            </td>
            <td style="width: 15%; vertical-align: top;">
              <div style="color: #000000;">United States</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Sarah Schlesinger</div>
            </td>
            <td style="width: 9.64%; vertical-align: top;">
              <div style="color: #000000;">(1)</div>
            </td>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Director</div>
            </td>
            <td style="width: 35%; vertical-align: top;">
              <div style="color: #000000;">Associate Professor of Clinical</div>
              <div style="color: #000000;">Investigation at Rockefeller</div>
              <div style="color: #000000;">University and Senior Attending</div>
              <div style="color: #000000;">Physician at Rockefeller University</div>
              <div style="color: #000000;">Hospital (6)</div>
            </td>
            <td style="width: 15%; vertical-align: top;">
              <div style="color: #000000;">United States</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
            <td style="width: 9.64%; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
            <td style="width: 35%; vertical-align: top;">&#160;</td>
            <td style="width: 15%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="color: #000000; font-weight: bold;">Executive Officers</div>
            </td>
            <td style="width: 9.64%; vertical-align: top;">&#160;</td>
            <td style="width: 20%; vertical-align: top;">&#160;</td>
            <td style="width: 35%; vertical-align: top;">&#160;</td>
            <td style="width: 15%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Pavel Raifeld</div>
            </td>
            <td style="width: 9.64%; vertical-align: top;">
              <div style="color: #000000;">(1)</div>
            </td>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">President</div>
            </td>
            <td style="width: 35%; vertical-align: top;">
              <div style="color: #000000;">Chief Executive Officer of INVA</div>
            </td>
            <td style="width: 15%; vertical-align: top;">
              <div style="color: #000000;">United States</div>
            </td>
          </tr>
          <tr>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Marianne Zhen</div>
            </td>
            <td style="width: 9.64%; vertical-align: top;">
              <div style="color: #000000;">(1)</div>
            </td>
            <td style="width: 20%; vertical-align: top;">
              <div style="color: #000000;">Secretary</div>
            </td>
            <td style="width: 35%; vertical-align: top;">
              <div style="color: #000000;">Chief Accounting Officer of INVA</div>
            </td>
            <td style="width: 15%; vertical-align: top;">
              <div style="color: #000000;">United States</div>
            </td>
          </tr>

      </table>
      <div>
        <div><br>
        </div>
      </div>
      <div>
        <div style="text-align: justify; color: #000000;">(1)&#8195;1350 Old Bayshore Highway Suite 400, Burlingame, CA.</div>
        <div style="text-align: justify; color: #000000;">(2)&#8195;M.M. Dillon &amp; Co., LLC is an investment banking firm. The address of M.M. Dillon &amp; Co., LLC is 1 Sound Shore Dr., Greenwich, CT 06830.</div>
        <div style="text-align: justify; color: #000000;">(3)&#8195;ActivePure is an air-cleaning technology company. The address of ActivePure is 14841 Dallas Parkway, Suite 500, Dallas, TX 75252.</div>
        <div style="text-align: justify; color: #000000;">(4)&#8195;Sarissa Capital Management LP is a registered investment advisor. The address of Sarissa Capital Management LP is 660 Steamboat Rd, Greenwich, CT 06830.</div>
        <div style="text-align: justify; color: #000000;">(5)&#8195;Haimovitz Consulting Inc. is a consulting firm. The address of Haimovitz Consulting, Inc. is N/A.</div>
        <div style="text-align: justify; color: #000000;">(6)&#8195;Rockefeller University and the Rockefeller University Hospital are a center for research and graduate education in the biomedical sciences, chemistry, bioinformatics and physics. The address of
          Rockefeller University and Rockefeller University Hospital is 1230 York Ave, New York, NY 10065.</div>
      </div>
      <br>
      <div><br>
      </div>
      <br>
    </div>
  </div>
  <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">- 7 -<br>
    </font></div>
  <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;"> <br>
    </font></div>
  <div id="DSPFPageNumberArea" style="text-align: center;">
    <hr style="height: 2px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
</body>
</html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
