    <SEC-DOCUMENT>0001140361-22-022099-index.html : 20220607
    <SEC-HEADER>0001140361-22-022099.hdr.sgml : 20220607
    <ACCEPTANCE-DATETIME>20220607091905
    ACCESSION NUMBER:		0001140361-22-022099
    CONFORMED SUBMISSION TYPE:	SC 13E3
    PUBLIC DOCUMENT COUNT:		25
    FILED AS OF DATE:		20220607
    DATE AS OF CHANGE:		20220607
    GROUP MEMBERS:		INNOVIVA MERGER SUB, INC.

    SUBJECT COMPANY:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Entasis Therapeutics Holdings Inc.
    		CENTRAL INDEX KEY:			0001724344
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				824592913
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		SC 13E3
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	005-90651
    		FILM NUMBER:		221000010

    	BUSINESS ADDRESS:
    		STREET 1:		35 GATEHOUSE DRIVE
    		CITY:			WALTHAM
    		STATE:			MA
    		ZIP:			02451
    		BUSINESS PHONE:		(781) 810-0120

    	MAIL ADDRESS:
    		STREET 1:		35 GATEHOUSE DRIVE
    		CITY:			WALTHAM
    		STATE:			MA
    		ZIP:			02451

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Entasis Therapeutics Ltd
    		DATE OF NAME CHANGE:	20171204

    FILED BY:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Innoviva, Inc.
    		CENTRAL INDEX KEY:			0001080014
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				943265960
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		SC 13E3

    	BUSINESS ADDRESS:
    		STREET 1:		1350 OLD BAYSHORE HIGHWAY
    		STREET 2:		SUITE 400
    		CITY:			BURLINGAME
    		STATE:			CA
    		ZIP:			94010
    		BUSINESS PHONE:		6502389600

    	MAIL ADDRESS:
    		STREET 1:		1350 OLD BAYSHORE HIGHWAY
    		STREET 2:		SUITE 400
    		CITY:			BURLINGAME
    		STATE:			CA
    		ZIP:			94010

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	THERAVANCE INC
    		DATE OF NAME CHANGE:	20020207

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	ADVANCED MEDICINE INC
    		DATE OF NAME CHANGE:	20000302
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>SC 13E3
    <SEQUENCE>1
    <FILENAME>ny20004467x1_sc13e3.htm
    <DESCRIPTION>SCHEDULE 13E-3
    <TEXT>
    Document 1 - file: ny20004467x1_sc13e3.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.(C)(2)
    <SEQUENCE>2
    <FILENAME>ny20004467x1_ex99c2.htm
    <DESCRIPTION>EXHIBIT 99(C)(2)
    <TEXT>
    Document 2 - file: ny20004467x1_ex99c2.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-FILING FEES
    <SEQUENCE>3
    <FILENAME>ny20004467x1_ex107.htm
    <DESCRIPTION>FILING FEES TABLE
    <TEXT>
    Document 3 - file: ny20004467x1_ex107.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>ny20004467x1_ex99c2slide01.jpg
    <TEXT>
    Document 4 - file: ny20004467x1_ex99c2slide01.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>ny20004467x1_ex99c2slide02.jpg
    <TEXT>
    Document 5 - file: ny20004467x1_ex99c2slide02.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>ny20004467x1_ex99c2slide03.jpg
    <TEXT>
    Document 6 - file: ny20004467x1_ex99c2slide03.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>ny20004467x1_ex99c2slide04.jpg
    <TEXT>
    Document 7 - file: ny20004467x1_ex99c2slide04.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>ny20004467x1_ex99c2slide05.jpg
    <TEXT>
    Document 8 - file: ny20004467x1_ex99c2slide05.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>ny20004467x1_ex99c2slide06.jpg
    <TEXT>
    Document 9 - file: ny20004467x1_ex99c2slide06.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>ny20004467x1_ex99c2slide07.jpg
    <TEXT>
    Document 10 - file: ny20004467x1_ex99c2slide07.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>ny20004467x1_ex99c2slide08.jpg
    <TEXT>
    Document 11 - file: ny20004467x1_ex99c2slide08.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>ny20004467x1_ex99c2slide09.jpg
    <TEXT>
    Document 12 - file: ny20004467x1_ex99c2slide09.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>ny20004467x1_ex99c2slide10.jpg
    <TEXT>
    Document 13 - file: ny20004467x1_ex99c2slide10.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>ny20004467x1_ex99c2slide11.jpg
    <TEXT>
    Document 14 - file: ny20004467x1_ex99c2slide11.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>15
    <FILENAME>ny20004467x1_ex99c2slide12.jpg
    <TEXT>
    Document 15 - file: ny20004467x1_ex99c2slide12.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>16
    <FILENAME>ny20004467x1_ex99c2slide13.jpg
    <TEXT>
    Document 16 - file: ny20004467x1_ex99c2slide13.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>17
    <FILENAME>ny20004467x1_ex99c2slide14.jpg
    <TEXT>
    Document 17 - file: ny20004467x1_ex99c2slide14.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>18
    <FILENAME>ny20004467x1_ex99c2slide15.jpg
    <TEXT>
    Document 18 - file: ny20004467x1_ex99c2slide15.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>19
    <FILENAME>ny20004467x1_ex99c2slide16.jpg
    <TEXT>
    Document 19 - file: ny20004467x1_ex99c2slide16.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>20
    <FILENAME>ny20004467x1_ex99c2slide17.jpg
    <TEXT>
    Document 20 - file: ny20004467x1_ex99c2slide17.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>21
    <FILENAME>ny20004467x1_ex99c2slide18.jpg
    <TEXT>
    Document 21 - file: ny20004467x1_ex99c2slide18.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>22
    <FILENAME>ny20004467x1_ex99c2slide19.jpg
    <TEXT>
    Document 22 - file: ny20004467x1_ex99c2slide19.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>23
    <FILENAME>ny20004467x1_ex99c2slide20.jpg
    <TEXT>
    Document 23 - file: ny20004467x1_ex99c2slide20.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>24
    <FILENAME>ny20004467x1_ex99c2slide21.jpg
    <TEXT>
    Document 24 - file: ny20004467x1_ex99c2slide21.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>25
    <FILENAME>ny20004467x1_ex99c2slide22.jpg
    <TEXT>
    Document 25 - file: ny20004467x1_ex99c2slide22.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>