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INCOME TAXES - Additional Tax Disclosures (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Income Taxes |  |  |  |
Accrued interest and penalties | $ 0 | $ 0 |  |
Uncertain Tax Positions |  |  |  |
Unrecognized tax benefits | 16,324 | 14,872 | $ 15,185 | $ 15,342
Net decrease in tax portions |  | $ (313) | $ (157) |
Net increase in tax portions | 1,452 |  |  |
Entasis Therapeutics Holdings Inc |  |  |  |
Income Taxes |  |  |  |
Federal net operating losses estimated utilization amount | 157,400 |  |  |
La Jolla Pharmaceutical Company |  |  |  |
Income Taxes |  |  |  |
Federal net operating losses estimated utilization amount | 254,000 |  |  |
Federal |  |  |  |
Income Taxes |  |  |  |
Net operating loss carryforwards | 411,500 |  |  |
State |  |  |  |
Income Taxes |  |  |  |
Net operating loss carryforwards | 955,300 |  |  |
State | Research and development |  |  |  |
Income Taxes |  |  |  |
Tax credit carryforward amount | $ 33,300 |  |  |

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