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v3.23.1

License and Collaboration Arrangements (Additional Information) (Details) $ in Thousands | 3 Months Ended
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Mar. 31, 2023 USD ($)
Zai Lab | Research and Development Support |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |
Revenues | $ 0
Future potential milestone payment receivable | 91,000
PAION AG |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |
Future potential milestone payment receivable | 109,500
Everest Medicines Limited |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |
Revenues | 0
Additional regulatory milestone payments receivable | 8,000
Sales milestone payments receivable | 20,000
License revenue recognized | $ 8,000
Royalties payable period after first commercial sale of product | 10 years
Everest Medicines Limited | Commercial Supply Agreement |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |
Percentage of reimbursed for direct and certain indirect manufacturing costs | 110.00%
Deferred revenue | $ 2,800
George Washington University |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |
Percentage of royalty payable on net sales | 6.00%
Percentage of royalty on payments received from sublicensees | 15.00%
Harvard University |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |
Percentage of royalty payable on net sales | 5.00%
Percentage of royalty on payments received from sublicensees | 20.00%
Cost of license revenue | $ 1,600
Clinical development and regulatory milestones amount payable | $ 15,100
Percentage of minimum royalty rate | 4.50%
Percentage of maximum royalty based on achievement of annual net product sales thresholds | 7.50%
Paratek Pharmaceuticals, Inc. |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |
Percentage of royalty payable on net sales | 2.25%
Claim expiration | 2023-10

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