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v3.23.3

License and Collaboration Arrangements (Additional Information) (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2023 | Sep. 30, 2022 | Sep. 30, 2023 | Sep. 30, 2022
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Net revenue | $ 67,259 | $ 67,257 | $ 224,623 | $ 265,536
Zai Lab | Research and Development Support |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Future potential milestone payment receivable | 91,000 |  | 91,000 |
License revenue recognized |  |  | 3 |
PAION AG |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Future potential milestone payment receivable | 109,500 |  | 109,500 |
PAION AG | Cost Reimbursement |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Revenues | 1,000 |  | 1,000 |
Everest Medicines Limited |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Revenues | 900 |  | 1,600 |
Sales milestone payments receivable | 20,000 |  | 20,000 |
License revenue recognized |  |  | $ 8,000 |
Royalties payable period after first commercial sale of product |  |  | 10 years |
Everest Medicines Limited | Commercial Supply Agreement |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Percentage of reimbursed for direct and certain indirect manufacturing costs |  |  | 110.00% |
George Washington University |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Percentage of royalty payable on net sales |  |  | 6.00% |
Percentage of royalty on payments received from sublicensees |  |  | 15.00% |
Obligation to pay royalties | $ 500 |  | $ 1,700 |
Harvard University |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Percentage of royalty payable on net sales |  |  | 5.00% |
Percentage of royalty on payments received from sublicensees |  |  | 20.00% |
Cost of license revenue |  |  | $ 1,600 |
Clinical development and regulatory milestones amount payable |  |  | $ 15,100 |
Percentage of minimum royalty rate |  |  | 4.50% |
Percentage of maximum royalty based on achievement of annual net product sales thresholds |  |  | 7.50% |
Paratek Pharmaceuticals, Inc. |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Percentage of royalty payable on net sales |  |  | 2.25% |
Claim expiration |  |  | 2023-10 |

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