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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2023 | Sep. 30, 2022
Cash flows from operating activities |  |
Net income (loss) | $ 118,191 | $ 288,576
Adjustments to reconcile net income to net cash provided by operating activities: |  |
Deferred income taxes | (1,115) | 29,258
Amortization of capitalized fees and depreciation of property and equipment | 10,437 | 10,447
Amortization of acquired intangible assets | 15,274 | 1,511
Inventory fair value step-up adjustment included in cost of products sold | 19,179 | 2,743
Stock-based compensation | 4,560 | 6,021
Amortization of debt discount and issuance costs | 1,549 | 1,491
Changes in fair values of equity method investments, net | (67,886) | 44,475
Changes in fair values of other equity and long-term investments, net | 4,887 | 21,973
Loss on extinguishment of debt | 0 | 20,662
Net gain on sale of TRC | 0 | (266,696)
Accrued interest income added to long-term investments | (1,482) | 0
Other non-cash items | (770) | 2,026
Changes in operating assets and liabilities: |  |
Accounts receivable | (1,351) | (867)
Receivables from collaboration arrangement | (2,341) | 2,385
Inventory | (3,797) | 350
Prepaid expenses | 14,830 | 277
Other assets | 1,795 | (2,932)
Accounts payable | 844 | 958
Accrued personnel-related expenses and other accrued liabilities | (1,072) | (1,709)
Accrued interest payable | (3,526) | (1,926)
Income tax payable | 148 | 33,804
Deferred revenue | (546) | 0
Net cash provided by operating activities | 107,808 | 192,827
Cash flows from investing activities |  |
Purchases of equity method investments | 0 | (45,000)
Purchases of trading securities | (60,132) | 0
Purchases of equity and long-term investments | (1,218) | (13,725)
Purchases of equity investments managed by ISP Fund LP | (24,914) | (92,951)
Sales of equity investments managed by ISP Fund LP | 39,642 | 24,281
Purchase and sales of other investments managed by ISP Fund LP, net | (14,728) | (41,330)
Purchases of property and equipment | (260) | (33)
Proceeds from sale of ownership interest in TRC, net | 0 | 248,191
Cash acquired through the consolidation of Entasis | 0 | 23,070
Cash paid for the acquisition of La Jolla Pharmaceutical Company, net of cash acquired | 0 | (150,459)
Net cash used in investing activities | (61,610) | (47,956)
Cash flows from financing activities |  |
Distributions to noncontrolling interests | 0 | (69,811)
Purchase of Entasis minority interest | 0 | (42,395)
Repurchase of common stock | (61,092) | 0
Repurchase of shares to satisfy tax withholding | (65) | (71)
Proceeds from issuances of common stock, net | 111 | 342
Payment for repurchase of convertible subordinated notes due 2023 | (96,204) | (165,131)
Purchases of capped call options associated with convertible senior notes due 2028 | 0 | (21,037)
Proceeds from issuance of convertible senior notes due 2028, net of issuance costs | 0 | 252,536
Net cash used in financing activities | (157,250) | (45,567)
Net (decrease) increase in cash and cash equivalents | (111,052) | 99,304
Cash and cash equivalents at beginning of period | 291,049 | 201,525
Cash and cash equivalents at end of period | 179,997 | 300,829
Supplemental Disclosure of Cash Flow Information: |  |
Cash paid for interest | 11,381 | 11,736
Cash paid for income taxes | 0 | 3,859
Supplemental Disclosure of Non-cash Investing and Financing Activities: |  |
Adoption of ASU 2020-06 | 0 | 28,123
Right-of-use asset obtained through the consolidation of Entasis Therapeutics Holdings, Inc. | 463 | 3,323
Reconciliation of Cash, Cash Equivalents and Restricted Cash: |  |
Cash and cash equivalents | 179,997 | 300,789
Restricted cash, included in "Other assets" | 0 | 40
Total cash, cash equivalents and restricted cash at end of period shown in the condensed consolidated statements of cash flows | $ 179,997 | $ 300,829

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