<SEC-DOCUMENT>0000899140-23-000652.txt : 20230515
<SEC-HEADER>0000899140-23-000652.hdr.sgml : 20230515
<ACCEPTANCE-DATETIME>20230515170545
ACCESSION NUMBER:		0000899140-23-000652
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20230515
DATE AS OF CHANGE:		20230515
GROUP MEMBERS:		ALEXANDER J. DENNER, PH.D.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Innoviva, Inc.
		CENTRAL INDEX KEY:			0001080014
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				943265960
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-80415
		FILM NUMBER:		23924073

	BUSINESS ADDRESS:	
		STREET 1:		1350 OLD BAYSHORE HIGHWAY
		STREET 2:		SUITE 400
		CITY:			BURLINGAME
		STATE:			CA
		ZIP:			94010
		BUSINESS PHONE:		6502389600

	MAIL ADDRESS:	
		STREET 1:		1350 OLD BAYSHORE HIGHWAY
		STREET 2:		SUITE 400
		CITY:			BURLINGAME
		STATE:			CA
		ZIP:			94010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	THERAVANCE INC
		DATE OF NAME CHANGE:	20020207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADVANCED MEDICINE INC
		DATE OF NAME CHANGE:	20000302

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sarissa Capital Management LP
		CENTRAL INDEX KEY:			0001577524
		IRS NUMBER:				900924432
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203-302-2330

	MAIL ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>s63832508.htm
<DESCRIPTION>SCHEDULE 13D/A, AMENDMENT #3
<TEXT>
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            <div style="text-align: center; text-indent: -10pt; margin-left: 10pt; color: #000000; font-size: 12pt; font-weight: bold;">UNITED STATES</div>
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            <div style="text-align: center; color: #000000; font-size: 12pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
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            <div style="text-align: center; text-indent: -10pt; margin-left: 10pt; color: #000000; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
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            <div style="text-align: center; text-indent: -10pt; margin-left: 10pt; color: #000000; font-size: 12pt; font-weight: bold;">SCHEDULE 13D</div>
            <div>&#160;</div>
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          <td style="width: 22.14%; vertical-align: bottom;">&#160;</td>
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    <div style="text-align: center; color: #000000; font-size: 12pt; font-weight: bold;">Under the Securities Exchange Act of 1934<br>
      (Amendment No. 3)*</div>
    <div><br>
    </div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; color: #000000; font-size: 12pt; font-weight: bold;">Innoviva, Inc.</div>
    <div style="text-align: center; color: #000000; font-size: 12pt;">(Name of Issuer)</div>
    <div><br>
    </div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; color: #000000; font-size: 12pt; font-weight: bold;">Common Stock, par value $0.01 per share</div>
    <div style="text-align: center; color: #000000; font-size: 12pt;">(Title of Class of Securities)</div>
    <div><br>
    </div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; color: #000000; font-size: 12pt; font-weight: bold;">45781M101</div>
    <div style="text-align: center; color: #000000; font-size: 12pt;">(CUSIP Number)</div>
    <div><br>
    </div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; color: #000000; font-size: 12pt; font-weight: bold;">Mark DiPaolo</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; color: #000000; font-size: 12pt; font-weight: bold;">Senior Partner and General Counsel</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; color: #000000; font-size: 12pt; font-weight: bold;">Sarissa Capital Management LP</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; color: #000000; font-size: 12pt; font-weight: bold;">660 Steamboat Road</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; color: #000000; font-size: 12pt; font-weight: bold;">Greenwich, CT 06830</div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; color: #000000; font-size: 12pt; font-weight: bold;">203-302-2330</div>
    <div style="text-align: center; color: #000000; font-size: 12pt;">(Name, Address and Telephone Number of Person<br>
      Authorized to Receive Notices and Communications)</div>
    <div><br>
    </div>
    <div style="text-align: center; margin-right: 6pt; margin-left: 6pt; color: #000000; font-size: 12pt; font-weight: bold;">May 11, 2023</div>
    <div style="text-align: center;"><font style="font-size: 12pt; color: #000000;">(Date of Event Which Requires Filing of this Statement)<br>
      </font><br>
    </div>
    <div style="color: #000000; font-size: 12pt;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e), 13d-1(f) or
      13d-1(g), check the following box. &#9744;</div>
    <div style="margin-top: 5pt; margin-bottom: 5pt; color: #000000; font-size: 12pt;"><font style="font-weight: bold;">Note</font>: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits.
      See Rule 13d-7 for other parties to whom copies are to be sent.</div>
    <div style="margin-top: 5pt; margin-bottom: 5pt; color: #000000; font-size: 12pt;">* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any
      subsequent amendment containing information which would alter disclosures provided in a prior cover page.</div>
    <div style="color: #000000; font-size: 12pt;">The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of
      that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
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          <td colspan="7" style="width: 100%; vertical-align: middle;">
            <div style="color: #000000; font-size: 12pt;">CUSIP No. 45781M101&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; SCHEDULE 13D</div>
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            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">1</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">NAME OF REPORTING PERSON OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON</div>
            <div style="color: #000000; font-size: 12pt;">Sarissa Capital Management LP</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">2</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
            <div style="color: #000000; font-size: 12pt;">(a) <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font> (b) <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
          </td>
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          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">3</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">SEC USE ONLY</div>
            <div style="color: #000000; font-size: 12pt;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">4</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">SOURCE OF FUNDS</div>
            <div style="color: #000000; font-size: 12pt;">AF</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">5</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR</div>
            <div style="color: #000000; font-size: 12pt;">2(e) <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
          </td>
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        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">6</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="color: #000000; font-size: 12pt;">DELAWARE</div>
          </td>
        </tr>
        <tr>
          <td colspan="3" rowspan="4" style="width: 18.41%; vertical-align: middle; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000; font-size: 12pt;">NUMBER OF</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">SHARES</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">BENEFICIALLY</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">OWNED BY</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">EACH</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">REPORTING</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">PERSON</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">WITH</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">7</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 69.88%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">SOLE VOTING POWER</div>
            <div style="color: #000000; font-size: 12pt;">0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">8</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">SHARED VOTING POWER</div>
            <div style="color: #000000; font-size: 12pt;">6,904,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">9</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">SOLE DISPOSITIVE POWER</div>
            <div style="color: #000000; font-size: 12pt;">0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">10</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">SHARED DISPOSITIVE POWER</div>
            <div style="color: #000000; font-size: 12pt;">6,904,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">11</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="color: #000000; font-size: 12pt;">6,904,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">12</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">13</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
            <div style="color: #000000; font-size: 12pt;">10.54%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">14</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="5" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">TYPE OF REPORTING PERSON</div>
            <div style="color: #000000; font-size: 12pt;">PN, IA</div>
          </td>
        </tr>

    </table>
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        <tr>
          <td colspan="7" style="width: 55.94%; vertical-align: middle;">
            <div style="color: #000000; font-size: 12pt;">CUSIP No. 45781M101&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; SCHEDULE 13D</div>
          </td>
          <td style="width: 44.06%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">1</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="6" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">NAME OF REPORTING PERSON OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON</div>
            <div style="color: #000000; font-size: 12pt;">Alexander J. Denner, Ph.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">2</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="6" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
            <div style="color: #000000; font-size: 12pt;">(a) <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font> (b) <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">3</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="6" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">SEC USE ONLY</div>
            <br>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">4</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="6" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">SOURCE OF FUNDS</div>
            <div style="color: #000000; font-size: 12pt;">AF</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">5</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="6" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR</div>
            <div style="color: #000000; font-size: 12pt;">2(e) <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">6</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="6" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="color: #000000; font-size: 12pt;">UNITED STATES</div>
          </td>
        </tr>
        <tr>
          <td colspan="3" rowspan="4" style="width: 18.41%; vertical-align: middle; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000; font-size: 12pt;">NUMBER OF</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">SHARES</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">BENEFICIALLY</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">OWNED BY</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">EACH</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">REPORTING</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">PERSON</div>
            <div style="text-align: center; color: #000000; font-size: 12pt;">WITH</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">7</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="2" style="width: 69.88%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">SOLE VOTING POWER</div>
            <div style="color: #000000; font-size: 12pt;">0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">8</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="2" style="width: 10.03%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">SHARED VOTING POWER</div>
            <div style="color: #000000; font-size: 12pt;">6,904,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">9</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="2" style="width: 10.03%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">SOLE DISPOSITIVE POWER</div>
            <div style="color: #000000; font-size: 12pt;">0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 8.35%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">10</div>
          </td>
          <td style="width: 1.68%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="2" style="width: 10.03%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">SHARED DISPOSITIVE POWER</div>
            <div style="color: #000000; font-size: 12pt;">6,904,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">11</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="6" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="color: #000000; font-size: 12pt;">6,904,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">12</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="6" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">13</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="6" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
            <div style="color: #000000; font-size: 12pt;">10.54%</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.37%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt;">14</div>
          </td>
          <td style="width: 1.69%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="6" style="width: 89.95%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt;">TYPE OF REPORTING PERSON</div>
            <div style="color: #000000; font-size: 12pt;">IN, HC</div>
          </td>
        </tr>

    </table>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
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    </div>
    <div style="text-align: center; color: #000000; font-size: 12pt; font-weight: bold;">Amendment No. 3 to Schedule 13D</div>
    <div><br>
    </div>
    <div style="color: #000000; font-size: 12pt;">This statement constitutes Amendment No. 3 to the Schedule 13D of the Reporting Persons (&#8220;Amendment No. 3&#8221;) relating to the Common Stock, par value $0.01 per share (the &#8220;Shares&#8221;), issued by Innoviva, Inc.
      (the &#8220;Issuer&#8221;), and hereby amends the initial statement on Schedule 13D filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on February 25, 2019 (the &#8220;Initial Schedule 13D&#8221;), as amended by Amendment No. 1 thereto filed on December 14, 2020
      (&#8220;Amendment No. 1&#8221;), Amendment No. 2 thereto filed on May 25, 2021 (&#8220;Amendment No. 2&#8221;), and this Amendment No. 3 (collectively, the &#8220;Schedule 13D&#8221;), to furnish the additional information set forth herein.&#160; This Amendment No. 3 amends the Schedule 13D
      as specifically set forth herein.</div>
    <div><br>
    </div>
    <div style="color: #000000; font-size: 12pt;">All capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Schedule 13D. Information given in response to each item shall be deemed incorporated
      by reference in all other items, as applicable.</div>
    <div>
      <div><br>
      </div>
    </div>
    <div style="color: #000000; font-size: 12pt; font-weight: bold;">Item 5. Interest in Securities of the Issuer</div>
    <div><br>
    </div>
    <div style="color: #000000; font-size: 12pt;">Item 5 (a), (b) and (c) of the Schedule 13D are hereby amended and restated as follows:</div>
    <div><br>
    </div>
    <div style="color: #000000; font-size: 12pt;">(a) As of the opening of the market on May 15, 2023, the Reporting Persons may be deemed to beneficially own, in the aggregate, 6,904,000 Shares representing approximately 10.54% of the Issuer&#8217;s outstanding
      Shares (based upon 65,504,384 Shares stated to be outstanding as of April 20, 2023, by the Issuer in the Issuer&#8217;s Form 10-Q filed with the Securities and Exchange Commission on May 9, 2023).</div>
    <div><br>
    </div>
    <div style="color: #000000; font-size: 12pt;">(b) For purposes of this Schedule 13D:</div>
    <div><br>
    </div>
    <div style="color: #000000; font-size: 12pt;">All of the Shares for which Sarissa Capital and Dr. Denner may be deemed to have beneficial ownership are held directly by the Sarissa Funds for which Sarissa Capital serves as the investment advisor.
      Sarissa Capital, as the investment advisor to the Sarissa Funds, may be deemed to have the shared power to vote or direct the vote of (and the shared power to dispose or direct the disposition of) the 6,904,000 Shares held by the Sarissa Funds.</div>
    <div><br>
    </div>
    <div style="color: #000000; font-size: 12pt;">By virtue of his position as the Chief Investment Officer of Sarissa Capital and as the managing member of Sarissa Capital&#8217;s general partner, Dr. Denner may be deemed to have the shared power to vote or
      direct the vote of (and the shared power to dispose or direct the disposition of) the 6,904,000 Shares held by the Sarissa Funds.</div>
    <div><br>
    </div>
    <div style="color: #000000; font-size: 12pt;">(c)</div>
    <div style="color: #000000; font-size: 12pt;">On May 11, 2023, the Sarissa Funds acquired 290,000 Shares at a weighted average price of $12.3359 per Share, in open market transactions at prices ranging from $12.25 to $12.43, inclusive, for an aggregate
      purchase price of $3,586,111.&#160; The Reporting Persons undertake to provide, upon request by the Staff of the SEC, full information regarding the number of Shares purchased at each separate price.</div>
    <div><br>
    </div>
    <div style="color: #000000; font-size: 12pt;">As of the opening of the market on May 15, 2023, except as set forth above, the Reporting Persons did not transact in the Shares in the past 60 days.</div>
    <div style="margin-top: 10pt;"><br>
    </div>
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    <div style="text-align: center; color: #000000; font-size: 12pt; font-weight: bold;">SIGNATURE</div>
    <div style="text-indent: 36pt; color: #000000; font-size: 12pt;">After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this statement is true, complete and correct.</div>
    <div><br>
    </div>
    <div style="color: #000000; font-size: 12pt;">Dated: May 15, 2023</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: rgb(0, 0, 0);" id="z922278de7b464f91a55a7fbf9ccff15e">

        <tr>
          <td colspan="2" style="vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">SARISSA CAPITAL MANAGEMENT LP</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td colspan="2" style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">By:</div>
          </td>
          <td style="width: 91.32%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt;"><u>/s/ Mark DiPaolo&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br>
              </u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 91.32%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Name: Mark DiPaolo</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 91.32%; vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Title: General Counsel</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td colspan="2" style="vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt;"><u>/s/Alexander J. Denner&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br>
              </u></div>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="vertical-align: top;">
            <div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Alexander J. Denner</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="vertical-align: top;">&#160;</td>
        </tr>

    </table>
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    </div>
    <div style="text-align: center; color: #000000; font-size: 12pt;"><u>SCHEDULE A</u></div>
    <div style="text-align: center; color: #000000; font-size: 12pt;">DIRECTORS AND EXECUTIVE OFFICERS OF THE REPORTING PERSONS</div>
    <div><br>
    </div>
    <div style="color: #000000; font-size: 12pt;">The following sets forth the name, position, and principal occupation of each director and executive officer of each of the Reporting Persons. Each such person is a citizen of the United States of America.
      Except as otherwise indicated, the business address of each director and officer is c/o Sarissa Capital Management LP, 660 Steamboat Road, Greenwich, CT 06830. To the best of the Reporting Persons' knowledge, except as set forth in this statement on
      Schedule 13D, none of the directors or executive officers of the Reporting Persons own any Shares.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zb86d66b052a9463a83c766bcb2aacf75">

        <tr>
          <td style="width: 50%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt; font-weight: bold;">Name</div>
          </td>
          <td style="width: 50%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="color: #000000; font-size: 12pt; font-weight: bold;">Position</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-size: 12pt;">Alexander J. Denner, Ph.D.</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-size: 12pt;">Chief Investment Officer of Sarissa Capital</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-size: 12pt;">Mark DiPaolo</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-size: 12pt;">Senior Partner and General Counsel of Sarissa Capital</div>
            <div>&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-size: 12pt;">Patrice Bonfiglio</div>
          </td>
          <td style="width: 50%; vertical-align: top;">
            <div style="color: #000000; font-size: 12pt;">President of Sarissa Capital</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
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</DOCUMENT>
</SEC-DOCUMENT>
