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LICENSE AND COLLABORATION ARRANGEMENTS - Additional Information (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
License revenue | $ (310,463) | $ (331,339) | $ (391,866)
Zai Lab | Research and Development Support |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Future potential milestone payment receivable | 91,000 |  |
License revenue recognized | 3,000 |  |
PAION AG |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Future potential milestone payment receivable | 109,500 |  |
PAION AG | Cost Reimbursement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Revenues | 1,300 |  |
Everest Medicines Limited |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Revenues | 1,400 |  |
Sales milestone payments receivable | 20,000 |  |
License revenue recognized | $ 8,000 |  |
Royalties payable period after first commercial sale of product | 10 years |  |
Everest Medicines Limited | Commercial Supply Agreement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Revenues | $ 2,400 | $ 800 |
Percentage of reimbursed for direct and certain indirect manufacturing costs | 110.00% |  |
George Washington University |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Obligation to pay royalties | $ 2,500 |  |
Percentage of royalty payable on net sales | 6.00% |  |
Percentage of royalty on payments received from sublicensees | 15.00% |  |
Harvard University |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Cost of license revenue | $ 1,200 |  |
Percentage of royalty payable on net sales | 5.00% |  |
Percentage of royalty on payments received from sublicensees | 20.00% |  |
Clinical development and regulatory milestones amount payable | $ 15,100 |  |
Percentage of minimum royalty rate | 4.50% |  |
Percentage of maximum royalty based on achievement of annual net product sales thresholds | 7.50% |  |
Paratek Pharmaceuticals, Inc |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Percentage of royalty payable on net sales | 2.25% |  |
Claim Expiration Date | 2023-10 |  |
AstraZeneca |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Subscription agreement one-time milestone payment on net sales | $ 5,000 |  |
Term of the milestone payment on net sales | 3 months |  |
Subscription agreement one-time milestone payment on first commercial sale | $ 10,000 |  |
Term of the milestone payment on first commercial sale | 2 years |  |

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