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Income Taxes - Additional Information (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Income Taxes |  |  |
Net increase in tax portions | $ 41,851 | $ 3,119 | $ 1,452
Accrued interest and penalties | 0 | $ 0 |
Federal |  |  |
Income Taxes |  |  |
Net operating loss carryforwards | 520,600 |  |
Net operating loss carryforwards do not expire | 456,500 |  |
Federal | Entasis Therapeutics Holdings Inc |  |  |
Income Taxes |  |  |
Net operating loss carryforwards | 154,800 |  |
Federal | La Jolla Pharmaceutical Company |  |  |
Income Taxes |  |  |
Net operating loss carryforwards | 365,800 |  |
State |  |  |
Income Taxes |  |  |
Net operating loss carryforwards | 1,000,000 |  |
State | Research and development |  |  |
Income Taxes |  |  |
Tax credit carryforward amount | $ 33,300 |  |

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