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License and Collaboration Arrangements (Additional Information) (Details) - USD ($) $ in Thousands | 4 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Dec. 31, 2022 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Oct. 31, 2024
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
License revenue |  | $ (358,711) | $ (310,463) | $ (331,339) |
Accounts receivable |  | 20,392 | 14,454 |  |
Maximum |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Future potential milestone payment receivable |  | 109,500 |  |  |
XACDURO |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
License revenue |  | (21,070) | (2,003) | 0 |
Royalty revenue |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
License revenue |  | (241,733) | (238,846) | (311,645) |
GIAPREZA |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
License revenue |  | (55,037) | (41,294) | (14,214) |
License and other revenue |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
License revenue |  | (19,486) | (11,000) | 0 |
XERAVA |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
License revenue |  | $ (21,385) | (17,320) | $ (5,480) |
Percentage of royalty payable on net sales |  | 2.25% |  |  |
Zai Lab |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Business combination deferred consideration |  | $ 5,300 |  |  |
Zai Lab | Amended Zai Agreement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
License and other revenue |  | 8,100 |  |  |
Accounts receivable |  | 1,600 |  |  |
Zai Lab | Interim Supply Agreement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Accounts receivable |  | 600 |  |  |
Amount on net product sales recognized |  | 6,300 |  |  |
Zai Lab | Manufacturing Stage Transfer Agreement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
License and other revenue |  | 3,400 |  |  |
Accounts receivable |  | 100 |  |  |
Zai Lab | Sulbactam Durlobactam |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
License revenue recognized |  | 8,000 |  |  |
Zai Lab | XACDURO |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
License revenue recognized |  |  | 3,000 |  |
Zai Lab | XACDURO | Regulatory Starting Material |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Letter agreement for purchase of material used for production value |  |  |  |  | $ 10,900
Zai Lab | Research and Development Support | Maximum |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Future potential milestone payment receivable |  | 91,000 |  |  |
PAION AG | Royalty revenue |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenues | $ 0 | $ 1,500 | 0 |  |
PAION AG | Cost Reimbursement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenues |  |  | 1,300 |  |
Everest Medicines Limited |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Royalties payable period after first commercial sale of product |  | 10 years |  |  |
Everest Medicines Limited | Commercial Supply Agreement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenues | 800 | $ 3,200 | $ 2,400 |  |
Percentage of reimbursed for direct and certain indirect manufacturing costs |  |  | 110.00% |  |
Everest Medicines Limited | Maximum |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Sales milestone payments receivable |  |  | $ 20,000 |  |
Everest Medicines Limited | Royalty revenue |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenues | 0 | 4,700 | 1,400 |  |
Everest Medicines Limited | License and other revenue |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenues |  |  | 8,000 |  |
Basilea |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Upfront payment under intangible asset |  | 4,000 |  |  |
George Washington University | GIAPREZA |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Obligation to pay royalties | 0 | $ 3,400 | 2,500 |  |
Percentage of royalty payable on net sales |  | 6.00% |  |  |
Percentage of royalty on payments received from sublicensees |  | 15.00% |  |  |
Harvard University |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Cost of license revenue |  | $ 1,400 | 1,200 |  |
Percentage of royalty payable on net sales |  | 5.00% |  |  |
Percentage of royalty on payments received from sublicensees |  | 20.00% |  |  |
Percentage of minimum royalty rate |  | 4.50% |  |  |
Percentage of maximum royalty based on achievement of annual net product sales thresholds |  | 7.50% |  |  |
Harvard University | Maximum |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Clinical development and regulatory milestones amount payable |  | $ 15,100 |  |  |
Harvard University | Royalty revenue |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenues | $ 0 | $ 0 | 0 |  |
Paratek Pharmaceuticals, Inc | XERAVA |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Claim Expiration Date |  | 2023-10 |  |  |
AstraZeneca | Durlobactam |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Subscription agreement one-time milestone payment on net sales |  | $ 5,000 |  |  |
Term of the milestone payment on net sales |  | 3 months |  |  |
RoyaltyExpense |  | $ 0 | $ 0 |  |
AstraZeneca | Zoliflodacin |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Subscription agreement one-time milestone payment on first commercial sale |  | $ 10,000 |  |  |
Term of the milestone payment on first commercial sale |  | 2 years |  |  |

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