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Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Income Taxes
Net increase in tax portions	$ 41,851	$ 3,119	$ 1,452
Accrued interest and penalties	0	$ 0
Federal
Income Taxes
Net operating loss carryforwards	520,600
Net operating loss carryforwards do not expire	456,500
Federal | Entasis Therapeutics Holdings Inc
Income Taxes
Net operating loss carryforwards	154,800
Federal | La Jolla Pharmaceutical Company
Income Taxes
Net operating loss carryforwards	365,800
State
Income Taxes
Net operating loss carryforwards	1,000,000
State | Research and development
Income Taxes
Tax credit carryforward amount	$ 33,300

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