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v3.25.1

License and Collaboration Arrangements (Additional Information) (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2025 | Mar. 31, 2024 | Dec. 31, 2024
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Accounts receivable | $ 16,673 |  | $ 20,392
Zai Lab |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Payment received for additional inventory purchase | 8,600 |  | 5,300
Zai Lab | Interim Supply Agreement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Accounts receivable | 600 |  | 600
Amount on net product sales recognized | 800 |  |
Zai Lab | Amended Zai Agreement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
License revenue recognized | 500 |  |
Accounts receivable | 600 |  | 1,600
Zai Lab | Manufacturing Stage Transfer Agreement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
License revenue recognized | 0 |  |
Zai Lab | Research and Development Support | Maximum |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Future potential milestone payment receivable | 91,000 |  |
Zai Lab | Royalty Revenue |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Revenues | 500 |  |
PAION AG | Maximum |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Future potential milestone payment receivable | 109,500 |  |
PAION AG | Cost Reimbursement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Revenues | 600 | $ 0 |
PAION AG | Royalty Revenue |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Revenues | $ 0 | 0 |
Everest Medicines Limited |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Royalties payable period after first commercial sale of product | 10 years |  |
Everest Medicines Limited | Maximum |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Sales milestone payments receivable | $ 20,000 |  |
Everest Medicines Limited | Commercial Supply Agreement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Revenues | $ 1,000 | 0 |
Percentage of reimbursed for direct and certain indirect manufacturing costs | 110.00% |  |
Everest Medicines Limited | Royalty Revenue |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Revenues | $ 0 | 0 |
George Washington University | GIAPREZA |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Percentage of royalty payable on net sales | 6.00% |  |
Percentage of royalty on payments received from sublicensees | 15.00% |  |
Obligation to pay royalties | $ 1,100 | 0 |
Harvard University |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Percentage of royalty payable on net sales | 5.00% |  |
Percentage of royalty on payments received from sublicensees | 20.00% |  |
Cost of license revenue | $ 0 | 0 |
Percentage of minimum royalty rate | 4.50% |  |
Percentage of maximum royalty based on achievement of annual net product sales thresholds | 7.50% |  |
Harvard University | Maximum |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Clinical development and regulatory milestones amount payable | $ 15,100 |  |
Basilea |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Upfront payment under intangible asset |  |  | $ 4,000
Astrazeneca | Durlobactam |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
One-time Milestone Payment on Net Sales | $ 5,000 |  |
Term of Milestone Payment for Net Sales | 3 months |  |
Royalty expense | $ 0 | $ 0 |
Astrazeneca | Zoliflodacin |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
One-time Milestone Payment on Commercial Sales | $ 10,000 |  |
Term of Milestone Payment for Commercial Sale | 2 years |  |

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