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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jun. 30, 2025 | Mar. 31, 2025 | Jun. 30, 2024 | Mar. 31, 2024 | Jun. 30, 2025 | Jun. 30, 2024 | Dec. 31, 2024
Cash flows from operating activities |  |  |  |  |  |  |
Net income | $ 63,688 | $ (46,584) | $ (34,685) | $ 36,532 | $ 17,104 | $ 1,847 |
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |  |  |  |  |
Deferred income taxes |  |  |  |  | (877) | (12,009) |
Amortization of capitalized fees and depreciation of property and equipment |  |  |  |  | 6,976 | 6,986 |
Amortization of acquired intangible assets | 6,500 |  | 6,400 |  | 13,022 | 12,880 |
Inventory fair value step-up adjustment included in cost of products sold |  |  |  |  | 625 | 10,306 |
Stock-based compensation |  |  |  |  | 4,569 | 3,098 |
Amortization of debt discount and issuance costs |  |  |  |  | 1,078 | 1,048 |
Changes in fair values of equity method investments, net | (13,082) |  | 60,108 |  | 467 | 24,766 |
Changes in fair values of equity and long-term investments, net | 11,280 |  | (30,556) |  | (54,019) | (43,891) | $ (59,161)
Other non-cash items |  |  |  |  | 423 | (153) |
Changes in operating assets and liabilities: |  |  |  |  |  |  |
Accounts receivable |  |  |  |  | (533) | (12,328) |
Receivables from collaboration arrangement |  |  |  |  | (1,362) | 2,423 |
Inventory |  |  |  |  | (17,146) | (6,233) |
Prepaid expenses |  |  |  |  | 4,453 | 13,146 |
Other assets |  |  |  |  | 774 | 1,604 |
Accounts payable |  |  |  |  | 3,250 | (4,678) |
Accrued personnel-related expenses and other accrued liabilities |  |  |  |  | 1,932 | (5,950) |
Accrued interest payable |  |  |  |  | (4) | 0 |
Income tax payable |  |  |  |  | 1,921 | 543 |
Deferred revenue |  |  |  |  | 1,999 | (422) |
Net cash provided by operating activities |  |  |  |  | 92,690 | 80,765 |
Cash flows from investing activities |  |  |  |  |  |  |
Purchases of trading securities |  |  |  |  | (34,674) | (43,136) |
Proceeds from trading securities |  |  |  |  | 5,097 | 0 |
Purchases of equity investments managed by ISP Fund LP |  |  |  |  | 0 | (30,892) |
Sales of equity investments managed by ISP Fund LP |  |  |  |  | 19,939 | 5,976 |
Purchases and sales of other investments managed by ISP Fund LP, net |  |  |  |  | 8,086 | 24,916 |
Sale of property and equipment |  |  |  |  | 0 | 98 |
Net cash used in investing activities |  |  |  |  | (1,552) | (43,038) |
Cash flows from financing activities |  |  |  |  |  |  |
Repurchase of common stock |  |  |  |  | 0 | (14,777) |
Repurchase of shares to satisfy tax withholding |  |  |  |  | (91) | (105) |
Proceeds from issuances of common stock, net |  |  |  |  | 1,521 | 645 |
Net cash provided by (used in) financing activities |  |  |  |  | 1,430 | (14,237) |
Net increase in cash and cash equivalents |  |  |  |  | 92,568 | 23,490 |
Cash and cash equivalents at beginning of period |  | $ 304,964 |  | $ 193,513 | 304,964 | 193,513 | 193,513
Cash and cash equivalents at end of period | $ 397,532 |  | $ 217,003 |  | 397,532 | 217,003 | $ 304,964
Supplemental Disclosure of Cash Flow Information: |  |  |  |  |  |  |
Cash paid for interest |  |  |  |  | 5,179 | 5,179 |
Cash paid for income taxes |  |  |  |  | 11,944 | 0 |
Supplemental Disclosure of Non-cash Investing and Financing Activities: |  |  |  |  |  |  |
2025 Notes converted to common stock |  |  |  |  | 500 | 0 |
Accrued interest income converted to long-term investments |  |  |  |  | $ 0 | $ 799 |

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