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v3.25.2

License and Collaboration Arrangements (Additional Information) (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jun. 30, 2025 | Jun. 30, 2024 | Jun. 30, 2025 | Jun. 30, 2024 | Dec. 31, 2024
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Accounts receivable | $ 20,925 |  | $ 20,925 |  | $ 20,392
Zai Lab |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
License revenue recognized |  | $ 8,000 |  | $ 8,000 |
Payment received for additional inventory purchase | 16,100 |  | 16,100 |  | 5,300
Zai Lab | Interim Supply Agreement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Accounts receivable | 1,400 |  | 1,400 |  | 600
Amount on net product sales recognized | 1,700 | 0 | 2,500 | 0 |
Zai Lab | Amended Zai Agreement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
License revenue recognized |  | 6,500 | 600 | 6,500 |
Accounts receivable |  |  |  |  | 1,600
Zai Lab | Manufacturing Stage Transfer Agreement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
License revenue recognized | 900 | 0 | 900 | 0 |
Zai Lab | Research and Development Support | Maximum |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Future potential milestone payment receivable | 91,000 |  | 91,000 |  |
Zai Lab | Royalty Revenue |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenues | 600 |  | 1,100 |  |
PAION AG | Maximum |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Future potential milestone payment receivable | 109,500 |  | 109,500 |  |
PAION AG | Cost Reimbursement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenues | 800 | 0 | 1,400 | 0 |
PAION AG | Royalty Revenue |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenues | 0 | 0 | $ 0 | 0 |
Everest Medicines Limited |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Royalties payable period after first commercial sale of product |  |  | 10 years |  |
Everest Medicines Limited | Maximum |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Sales milestone payments receivable | 20,000 |  | $ 20,000 |  |
Everest Medicines Limited | Commercial Supply Agreement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenues | 800 | 800 | $ 1,800 | 1,700 |
Percentage of reimbursed for direct and certain indirect manufacturing costs |  |  | 110.00% |  |
Everest Medicines Limited | Royalty Revenue |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Revenues | 2,000 | 1,200 | $ 2,000 | 1,800 |
George Washington University | GIAPREZA |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Percentage of royalty payable on net sales |  |  | 6.00% |  |
Percentage of royalty on payments received from sublicensees |  |  | 15.00% |  |
Royalty expense | 1,100 | 700 | $ 2,200 | 1,400 |
Harvard University |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Percentage of royalty payable on net sales |  |  | 5.00% |  |
Percentage of royalty on payments received from sublicensees |  |  | 20.00% |  |
Percentage of minimum royalty rate |  |  | 4.50% |  |
Percentage of maximum royalty based on achievement of annual net product sales thresholds |  |  | 7.50% |  |
Royalty expense | 600 | 500 | $ 700 | 1,200 |
Harvard University | Maximum |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Clinical development and regulatory milestones amount payable |  |  | 15,100 |  |
Basilea |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Upfront payment under intangible asset |  |  |  |  | $ 4,000
Astrazeneca | Durlobactam |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
One-time Milestone Payment on Net Sales |  |  | $ 5,000 |  |
Term of Milestone Payment for Net Sales |  |  | 3 months |  |
Royalty expense | $ 0 | $ 0 | $ 0 | $ 0 |
Astrazeneca | Zoliflodacin |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
One-time Milestone Payment on Commercial Sales |  |  | $ 10,000 |  |
Term of Milestone Payment for Commercial Sale |  |  | 2 years |  |

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