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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2025
Mar. 31, 2025
Sep. 30, 2024
Mar. 31, 2024
Sep. 30, 2025
Sep. 30, 2024
Dec. 31, 2024
Cash flows from operating activities              
Net income $ 89,908 $ (46,584) $ 1,213 $ 36,532 $ 107,012 $ 3,060  
Adjustments to reconcile net income to net cash provided by operating activities:              
Deferred income taxes         4,072 (15,438)  
Amortization of capitalized fees and depreciation of property and equipment         10,464 10,466  
Amortization of acquired intangible assets 6,600   6,500   19,640 19,391  
Inventory fair value step-up adjustment included in cost of products sold         4,109 12,101  
Stock-based compensation         6,949 4,701  
Amortization of debt discount and issuance costs         1,533 1,581  
Changes in fair values of equity method investments, net (30,751)   18,231   (30,284) 42,997  
Changes in fair values of equity and long-term investments, net (31,510)   16,936   22,509 60,827 $ 59,161
Acquired in-process research and development assets         9,368 0  
Other non-cash items         402 (324)  
Changes in operating assets and liabilities:              
Accounts receivable         (9,775) (16,092)  
Receivables from collaboration arrangement         2,622 9,109  
Inventory         (10,299) (5,600)  
Prepaid expenses         1,648 8,980  
Other assets         1,001 594  
Accounts payable         4,111 (2,547)  
Accrued personnel-related expenses and other accrued liabilities         (14,568) (3,977)  
Accrued interest payable         (3,191) (2,589)  
Income tax payable         2,649 2,771  
Deferred revenue         12,445 (560)  
Net cash provided by operating activities         142,417 129,451  
Cash flows from investing activities              
Purchases of trading securities         (49,674) (48,136)  
Proceeds from trading securities         5,097 0  
Purchases of equity investments managed by ISP Fund LP         0 (32,270)  
Sales of equity investments managed by ISP Fund LP         19,939 52,831  
Purchases and sales of other investments managed by ISP Fund LP, net         51,987 (20,561)  
Purchases of property and equipment         (1,121) (270)  
Cash paid for in-process research and development assets acquired         (9,368) 0  
Sale of property and equipment         0 98  
Net cash provided by (used in) investing activities         16,860 (48,308)  
Cash flows from financing activities              
Repurchase of common stock         0 (14,777)  
Repurchase of shares to satisfy tax withholding         (116) (123)  
Proceeds from issuances of common stock, net         1,715 874  
Proceeds from exercise of warrants 10,700       10,698 0  
Payment for repurchase of convertible subordinated notes due 2025         (25) 0  
Net cash provided by (used in) financing activities         12,272 (14,026)  
Net increase in cash and cash equivalents         171,549 67,117  
Cash and cash equivalents at beginning of period   $ 304,964   $ 193,513 304,964 193,513 193,513
Cash and cash equivalents at end of period $ 476,513   $ 260,630   476,513 260,630 $ 304,964
Supplemental Disclosure of Cash Flow Information:              
Cash paid for interest         10,353 10,359  
Cash paid for income taxes         13,071 11,793  
Supplemental Disclosure of Non-cash Investing and Financing Activities:              
2025 Notes converted to common stock         192,475 0  
Accrued interest income converted to long-term investments         $ 0 $ 2,090