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License, Collaboration and Other Arrangements (Additional Information) (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Nov. 30, 2025 | Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
License revenue |  | $ (411,328) | $ (358,711) | $ (310,463)
Research and development expense |  | 30,604 | 13,654 | 33,922
Accounts receivable |  | 34,966 | 20,392 |
XACDURO |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
License revenue |  | (74,393) | (21,070) | (2,003)
Royalty Revenue |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
License revenue |  | (236,479) | (241,733) | (238,846)
GIAPREZA |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
License revenue |  | (73,611) | (55,037) | (41,294)
License and other revenue |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
License revenue |  | (2,719) | (19,486) | (11,000)
XERAVA |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
License revenue |  | (23,516) | (21,385) | (17,320)
Zai Lab |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
License revenue recognized |  |  | 8,000 |
Advance payments received |  |  | 5,300 |
Zai Lab | Amended Zai Agreement |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
License revenue recognized |  | 1,300 | 8,100 |
Accounts receivable |  | 1,800 | 1,600 |
Zai Lab | Interim Supply Agreement |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Accounts receivable |  | 6,700 | 600 |
Amount on net product sales recognized |  | 37,900 | 6,300 |
Zai Lab | Manufacturing Stage Transfer Agreement |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
License and other revenue |  | 1,100 | 3,400 |
Zai Lab | XACDURO |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
License revenue recognized |  |  |  | 3,000
Zai Lab | Research and Development Support | Maximum |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Future potential milestone payment receivable |  | 91,000 |  |
Zai Lab | Royalty Revenue |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Revenues |  | 2,400 |  |
PAION AG | Maximum |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Future potential milestone payment receivable |  | 109,500 |  |
PAION AG | Royalty Revenue |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Revenues |  | 1,600 | 1,500 | 0
PAION AG | Cost Reimbursement |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Revenues |  | $ 2,700 | 0 | 1,300
Everest Medicines Limited |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Royalties payable period after first commercial sale of product |  | 10 years |  |
Everest Medicines Limited | Commercial Supply Agreement |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Revenues |  | $ 4,000 | 3,200 | 2,400
Percentage of reimbursed for direct and certain indirect manufacturing costs |  | 110.00% |  |
Everest Medicines Limited | Maximum |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Sales milestone payments receivable |  | $ 20,000 |  |
Everest Medicines Limited | Royalty Revenue |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Revenues |  | 3,600 | 4,700 | 1,400
Everest Medicines Limited | License and other revenue |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Revenues |  |  |  | 8,000
GARDP Collaboration Agreement |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Research and development expense |  | $ 1,000 |  |
Basilea |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Upfront payment under intangible asset |  |  | 4,000 |
George Washington University | GIAPREZA |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Percentage of royalty payable on net sales |  | 6.00% |  |
Percentage of royalty on payments received from sublicensees |  | 15.00% |  |
Royalty expense |  | $ 4,500 | 3,400 | 2,500
Harvard University |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Cost of license revenue |  |  |  | 1,200
Percentage of royalty on payments received from sublicensees |  | 20.00% |  |
Royalty expense |  | $ 1,400 | 1,400 |
Harvard University | U.S. |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Percentage of royalty payable on net sales |  | 5.00% |  |
Harvard University | Non-US |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Percentage of minimum royalty rate |  | 4.50% |  |
Percentage of maximum royalty based on achievement of annual net product sales thresholds |  | 7.50% |  |
Harvard University | Maximum |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Clinical development and regulatory milestones amount payable |  | $ 15,100 |  |
Paratek Pharmaceuticals, Inc | XERAVA |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Percentage of royalty payable on net sales |  | 2.25% |  |
Claim expiration date |  | 2023-10 |  |
Massachusetts Institute of Technology |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Upfront fee payment |  | $ 500 |  |
Massachusetts Institute of Technology | Development Regulatory and Sales Milestone | Maximum |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Future potential milestone payment receivable |  | 17,500 |  |
AstraZeneca | Durlobactam |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
One-time Milestone Payment on Net Sales |  | $ 5,000 |  |
Term of the milestone payment on net sales |  | 3 months |  |
Royalty expense |  | $ 0 | $ 0 | $ 0
AstraZeneca | Zoliflodacin |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
One-time milestone payment on commercial sales |  | $ 10,000 |  |
Term of milestone payment for commercial sale |  | 2 years |  |
Gates Foundation |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |
Grant Funding Maximum Amount | $ 5,000 |  |  |
License revenue recognized |  | $ 100 |  |
Upfront fee received |  | $ 1,600 |  |

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