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v3.25.4

Revenue Recognition (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2014
Disaggregation of Revenue [Line Items] |  |  |  |
Total net revenue | $ 411,328 | $ 358,711 | $ 310,463 |
Milestone fees paid | 220,000 | 220,000 |  |
Net product sales |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Total net revenue | 172,130 | 97,492 | $ 60,617 |
U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Milestone fees paid | $ 120,000 | $ 120,000 |  |
Net Product Sales | Geographic Concentration Risk | U.S. |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Concentration Risk, Percentage | 69.00% | 83.00% | 91.00% |
Net Product Sales | Geographic Concentration Risk | Rest of the world |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Concentration Risk, Percentage | 31.00% | 17.00% | 9.00% |
GSK | Long-Acting Beta2 Agonist (LABA) Collaboration |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Milestone fees paid |  |  |  | $ 220,000
GSK | RELVAR/BREO | Long-Acting Beta2 Agonist (LABA) Collaboration |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Royalty rate for first level of annual global net sales (as a percent) | 15.00% |  |  |
Annual global sales level used to determine royalty rate | $ 3,000,000 |  |  |
Royalty rate for sales above first level of annual global net sales (as a percent) | 5.00% |  |  |
GSK | ANORO | Long-Acting Beta2 Agonist (LABA) Collaboration | Minimum |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Royalty rate for combination products (as a percent) | 6.50% |  |  |
GSK | ANORO | Long-Acting Beta2 Agonist (LABA) Collaboration | Maximum |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |
Royalty rate for combination products (as a percent) | 10.00% |  |  |

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