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Revenue Recognition (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2014
Disaggregation of Revenue [Line Items]
Total net revenue	$ 411,328	$ 358,711	$ 310,463
Milestone fees paid	220,000	220,000
Net product sales
Disaggregation of Revenue [Line Items]
Total net revenue	172,130	97,492	$ 60,617
U.S.
Disaggregation of Revenue [Line Items]
Milestone fees paid	$ 120,000	$ 120,000
Net Product Sales | Geographic Concentration Risk | U.S.
Disaggregation of Revenue [Line Items]
Concentration Risk, Percentage	69.00%	83.00%	91.00%
Net Product Sales | Geographic Concentration Risk | Rest of the world
Disaggregation of Revenue [Line Items]
Concentration Risk, Percentage	31.00%	17.00%	9.00%
GSK | Long-Acting Beta2 Agonist (LABA) Collaboration
Disaggregation of Revenue [Line Items]
Milestone fees paid				$ 220,000
GSK | RELVAR/BREO | Long-Acting Beta2 Agonist (LABA) Collaboration
Disaggregation of Revenue [Line Items]
Royalty rate for first level of annual global net sales (as a percent)	15.00%
Annual global sales level used to determine royalty rate	$ 3,000,000
Royalty rate for sales above first level of annual global net sales (as a percent)	5.00%
GSK | ANORO | Long-Acting Beta2 Agonist (LABA) Collaboration | Minimum
Disaggregation of Revenue [Line Items]
Royalty rate for combination products (as a percent)	6.50%
GSK | ANORO | Long-Acting Beta2 Agonist (LABA) Collaboration | Maximum
Disaggregation of Revenue [Line Items]
Royalty rate for combination products (as a percent)	10.00%

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