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Note 6 - Stockholders' Equity and Stock-based Compensation (Tables) | 9 Months Ended
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Sep. 30, 2025
Notes Tables |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Cost of product revenue |  | $ | 52 |  |  | $ | — |  |  | $ | 52 |  |  | $ | — |
Research and development |  |  | 2,232 |  |  |  | 1,108 |  |  |  | 7,329 |  |  |  | 3,058 |
Selling, general and administrative |  |  | 3,333 |  |  |  | 1,874 |  |  |  | 9,106 |  |  |  | 3,735 |
Total stock-based compensation expense |  | $ | 5,617 |  |  | $ | 2,982 |  |  | $ | 16,487 |  |  | $ | 6,793 |
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Time-based options |  | $ | 3,937 |  |  | $ | 2,131 |  |  | $ | 11,623 |  |  | $ | 4,609 |
Performance-based options |  |  | — |  |  |  | 5 |  |  |  | — |  |  |  | 27 |
Market-based options |  |  | 1,577 |  |  |  | 788 |  |  |  | 4,581 |  |  |  | 1,978 |
ESPP |  |  | 103 |  |  |  | 58 |  |  |  | 283 |  |  |  | 179 |
Total stock-based compensation expense |  | $ | 5,617 |  |  | $ | 2,982 |  |  | $ | 16,487 |  |  | $ | 6,793 |
The 2015 Plan, 2017 Plan and Inducement Plan [Member] |
Notes Tables |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Stock Options Outstanding |
|  | Number of shares |  |  | Weighted average exercise price |  |  | Weighted average remaining life (in years) |
Balances — December 31, 2024 |  |  | 10,979,332 |  |  | $ | 9.59 |  |  |  | 7.11 |
Options granted |  |  | 2,884,343 |  |  |  | 18.67 |  |  |  |  |
Options exercised |  |  | (493,431 | ) |  |  | 4.26 |  |  |  |  |
Options canceled |  |  | (66,500 | ) |  |  | 13.13 |  |  |  |  |
Options expired |  |  | — |  |  |  | — |  |  |  |  |
Balances — September 30, 2025 |  |  | 13,303,744 |  |  | $ | 11.74 |  |  |  | 7.24 |
Exercisable — September 30, 2025 |  |  | 4,806,075 |  |  | $ | 13.44 |  |  |  | 5.20 |
The 2017 Employee Stock Purchase Plan [Member] |
Notes Tables |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Expected term in years |  |  | 0.5 - 1.0 |  |  |  | 0.5 - 1.0 |  |  |  | 0.5 - 1.0 |  |  |  | 0.5 - 1.0 |
Expected volatility |  |  | 98% |  |  |  | 98% |  |  |  | 98% |  |  |  | 98% |
Risk-free interest rate |  |  | 3.8% - 4.0% |  |  |  | 4.4% - 5.3% |  |  |  | 3.8% - 4.3% |  |  |  | 4.9% - 5.3% |
Dividend yield |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Share-Based Payment Arrangement, Option [Member] |
Notes Tables |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Expected term in years |  |  | 5.2 - 6.3 |  |  |  | 5.0 - 6.3 |  |  |  | 5.0 - 6.9 |  |  |  | 5.0 - 6.3 |
Expected volatility |  |  | 93% - 95% |  |  |  | 93% - 97% |  |  |  | 93% - 100% |  |  |  | 91% - 97% |
Risk-free interest rate |  |  | 4.0% - 4.1% |  |  |  | 4.5% |  |  |  | 4.0% - 4.6% |  |  |  | 4.0% - 4.5% |
Dividend yield |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Expected term in years |  |  | 2.2 - 4.5 |  |  |  | 2.2 - 4.2 |  |  |  | 2.2 - 7.0 |  |  |  | 2.2 - 5.8 |
Expected volatility |  |  | 90% |  |  |  | 90% |  |  |  | 90% |  |  |  | 90% |
Risk-free interest rate |  |  | 3.9% |  |  |  | 3.9% |  |  |  | 3.9% - 4.6% |  |  |  | 3.9% - 4.4% |
Dividend yield |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Expected term in years |  |  | — |  |  |  | — |  |  |  | 6.1 - 8.9 |  |  |  | — |
Expected volatility |  |  | — |  |  |  | — |  |  |  | 90% |  |  |  | — |
Risk-free interest rate |  |  | — |  |  |  | — |  |  |  | 4.4% - 4.6% |  |  |  | — |
Dividend yield |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |

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