<SUBMISSION>
<ACCESSION-NUMBER>0001209191-08-036577
<TYPE>3
<PUBLIC-DOCUMENT-COUNT>1
<PERIOD>20080611
<FILING-DATE>20080612
<DATE-OF-FILING-DATE-CHANGE>20080612
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>Fifth Street Finance Corp
<CIK>0001414932
<IRS-NUMBER>261219283
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>0930
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>WHITE PLAINS PLAZA
<STREET2>445 HAMILTON AVENUE, SUITE 1206
<CITY>WHITE PLAINS
<STATE>NY
<ZIP>10601
<PHONE>(914) 286-6800
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>WHITE PLAINS PLAZA
<STREET2>445 HAMILTON AVENUE, SUITE 1206
<CITY>WHITE PLAINS
<STATE>NY
<ZIP>10601
</MAIL-ADDRESS>
</ISSUER>
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>EINHORN DAVID
<CIK>0001240451
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>3
<ACT>34
<FILE-NUMBER>814-00755
<FILM-NUMBER>08894833
</FILING-VALUES>
<BUSINESS-ADDRESS>
<PHONE>2129731900
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>420 LEXINGTON AVE
<STREET2>SUITE 1740
<CITY>NEW YORK
<STATE>NY
<ZIP>10170
</MAIL-ADDRESS>
</REPORTING-OWNER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>bod57623_bod1de.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2008-06-11</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001414932</issuerCik>
        <issuerName>Fifth Street Finance Corp</issuerName>
        <issuerTradingSymbol>FSC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001240451</rptOwnerCik>
            <rptOwnerName>EINHORN DAVID</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>140 EAST 45TH STREET</rptOwnerStreet1>
            <rptOwnerStreet2>24TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10017</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1440736</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">The filing of this Form 3 shall not be construed as an admission that David Einhorn, the senior managing member of Greenlight Capital, L.L.C. (&quot;Greenlight LLC&quot;) and DME Advisors GP, LLC (&quot;DME GP&quot;) and the president of Greenlight Capital, Inc. (&quot;Greenlight Inc.&quot; together with Greenlight LLC and DME GP, the &quot;Greenlight Entities&quot;), is or was for the purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, the beneficial owner of any of the shares of common stock, par value $0.01 per share (the &quot;Common Stock&quot;), of Fifth Street Finance Corp. (the &quot;Issuer&quot;), owned by multiple private investment funds and a managed account controlled or advised by the Greenlight Entities (collectively, the &quot;Greenlight Investors&quot;).  Pursuant to Rule 16a-1, Mr. Einhorn disclaims beneficial ownership except to the extent of his pecuniary interests.</footnote>
        <footnote id="F2">The Greenlight Entities collectively control the voting and disposition of 1,440,736 shares of Common Stock through the accounts of the Greenlight Investors.  The Greenlight Entities recieve an allocation of net profits from the Greenlight Investors.  Mr. Einhorn reports the shares of Common Stock held indirectly by the Greenlight Entities because, as the senior managing member of Greenlight LLC and DME GP, and the president of Greenlight Inc., at the time of purchase by the Greenlight Investors, Mr. Einhorn controlled the disposition and voting of the securities.  Additionally, Mr. Einhorn owns a limited partnership interest in one of the Greenlight Investors.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Daniel Roitman, on behalf of David Einhorn</signatureName>
        <signatureDate>2008-06-12</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SUBMISSION>
