<SUBMISSION>
<ACCESSION-NUMBER>0001181431-09-050769
<TYPE>4
<PUBLIC-DOCUMENT-COUNT>1
<PERIOD>20091106
<FILING-DATE>20091110
<DATE-OF-FILING-DATE-CHANGE>20091110
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>Fifth Street Finance Corp
<CIK>0001414932
<IRS-NUMBER>261219283
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>0930
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>10 BANK STREET
<STREET2>SUITE 1210
<CITY>WHITE PLAINS
<STATE>NY
<ZIP>10601
<PHONE>(914) 286-6800
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>10 BANK STREET
<STREET2>SUITE 1210
<CITY>WHITE PLAINS
<STATE>NY
<ZIP>10601
</MAIL-ADDRESS>
</ISSUER>
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>Genworth Life Insurance CO
<CIK>0001437475
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>4
<ACT>34
<FILE-NUMBER>814-00755
<FILM-NUMBER>091170517
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>6620 WEST BROAD STREET
<CITY>RICHMOND
<STATE>VA
<ZIP>23230
<PHONE>(804) 281-6000
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>6620 WEST BROAD STREET
<CITY>RICHMOND
<STATE>VA
<ZIP>23230
</MAIL-ADDRESS>
</REPORTING-OWNER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd256658.xml
<DESCRIPTION>GLIC FORM 4 (11-6-09)
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2009-11-06</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0001414932</issuerCik>
        <issuerName>Fifth Street Finance Corp</issuerName>
        <issuerTradingSymbol>FSC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001437475</rptOwnerCik>
            <rptOwnerName>Genworth Life Insurance CO</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>6620 WEST BROAD STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>RICHMOND</rptOwnerCity>
            <rptOwnerState>VA</rptOwnerState>
            <rptOwnerZipCode>23230</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-11-06</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>9.8068</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1472379</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <remarks>1. The reported securities are owned directly by Genworth Life Insurance Company and indirectly by Genworth North America Corporation, as parent of Genworth Life Insurance Company, and indirectly by Genworth Financial, Inc., as parent of Genworth North America Corporation.
2. Genworth Life Insurance Company is no longer a 10% owner of common stock of the Issuer and, therefore, no longer subject to Section 16 of the Securities Exchange Act of 1934.</remarks>

    <ownerSignature>
        <signatureName>/s/ Patricia Merrill, by power of attorney</signatureName>
        <signatureDate>2009-11-10</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SUBMISSION>
