<SEC-DOCUMENT>0001179110-14-009313.txt : 20140528
<SEC-HEADER>0001179110-14-009313.hdr.sgml : 20140528
<ACCEPTANCE-DATETIME>20140528213143
ACCESSION NUMBER:		0001179110-14-009313
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20140527
FILED AS OF DATE:		20140528
DATE AS OF CHANGE:		20140528

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Pacira Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001396814
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		5 SYLVAN WAY
		STREET 2:		SUITE 100
		CITY:			PARSIPPANY
		STATE:			NJ
		ZIP:			07054
		BUSINESS PHONE:		973-254-3560

	MAIL ADDRESS:	
		STREET 1:		5 SYLVAN WAY
		STREET 2:		SUITE 100
		CITY:			PARSIPPANY
		STATE:			NJ
		ZIP:			07054

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PACIRA INC
		DATE OF NAME CHANGE:	20080318

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Blue Acquisition Corp
		DATE OF NAME CHANGE:	20070418

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Wicki Andreas
		CENTRAL INDEX KEY:			0001511472

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35060
		FILM NUMBER:		14874159

	MAIL ADDRESS:	
		STREET 1:		C/O HBM BIOVENTURES (CAYMAN) LTD.
		STREET 2:		CENTENNIAL TOWERS,STE.305,2454 W.BAY RD.
		CITY:			GRAND CAYMAN
		STATE:			E9
		ZIP:			E9
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>FORM 4 -
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2014-05-27</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001396814</issuerCik>
        <issuerName>Pacira Pharmaceuticals, Inc.</issuerName>
        <issuerTradingSymbol>PCRX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001511472</rptOwnerCik>
            <rptOwnerName>Wicki Andreas</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>GOVERNORS SQUARE, SUITE 4-212-2,</rptOwnerStreet1>
            <rptOwnerStreet2>23 LIME TREE BAY AVE. WEST BAY</rptOwnerStreet2>
            <rptOwnerCity>GRAND CAYMAN</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>00000</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2014-05-27</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>64400</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>77.9309</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1531307</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote.</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by HBM Healthcare Investments (Cayman) Ltd.(&quot;HBM&quot;) on March 17,2014.</footnote>
        <footnote id="F2">The price reported in Column 4 is a weighted average price.  Thses shares were sold in multiple transactions at prices ranging from $77.80 to $78.345, inclusive.  Upon request, the reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission, full information regarding the shares sold at each separate price within the ranges set forth in footnote two (2) of this Form 4.</footnote>
        <footnote id="F3">The Board of Directors of HBM (the &quot;HBM Board&quot;) has sole voting and investment power with respect to the securities held by such entity and acts by majority vote.  The reporting person does not have sole voting or investment power over the securities held by HBM.  However, the reporting person may be deemed to have beneficial ownership of these securities by virtue of his membership on the HBM Board.  The reporting person disclaims beneficial ownership of the securities reported herein for the purposes of Rule 16a-1 (a) under the Securities Exchange Act of 1934, as amended (the &quot;Exchange Act&quot;), except to the extent of his pecuniary interest herein, if any.  This report on Form 4 shall not be deemed an admission that the rporting person is a beneficial owner for the purposes of Section 16 of the Exchange Act, or for any other purpose of Section 16 of the Exchange Act, or for any other purpose.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Mehdi Khodadad (Attorney-in-Fact)</signatureName>
        <signatureDate>2014-05-28</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
