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STOCK PLANS (Tables)
 12 Months Ended
Dec. 31, 2017
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of information about the plans
The following table contains information about the Company’s plans at December 31, 2017:
Stock Incentive Plans
 
Awards Reserved for Issuance
 
Awards
Issued
 
Awards Available for Grant
2007 Plan
 
2,022,837

 
2,022,837

 
—

2011 Plan
 
9,931,700

 
7,037,947

 
2,893,753

2014 Inducement plan
 
175,000

 
52,276

 
122,724

 
 
12,129,537

 
9,113,060

 
3,016,477

 
 
 
 
 
 
 
Employee Stock Purchase Plan
 
Shares Reserved
for Purchase
 
Shares
Purchased
 
Shares Available
for Purchase
2014 ESPP
 
500,000

 
160,147

 
339,853
Schedule of recognized stock-based compensation in consolidated statements of operations
The Company recognized stock-based compensation expense (net of forfeitures) in its consolidated statements of operations for the years ended December 31, 2017, 2016 and 2015 as follows (in thousands):
 
 
Year Ended December 31,
 
 
2017
 
2016
 
2015
Cost of goods sold
 
$
5,467

 
$
6,438

 
$
6,012

Research and development
 
3,341

 
3,297

 
5,134

Selling, general and administrative
 
22,793

 
21,513

 
22,222

Total
 
$
31,601

 
$
31,248

 
$
33,368

 
 
 
 
 
 
 
Stock-based compensation from:
 
 
 
 
 
 
   Stock options (employee awards)
 
$
24,056

 
$
24,505

 
$
27,262

   Stock options (consultant awards)
 
167

 
841

 
2,367

   RSUs
 
6,698

 
5,117

 
2,887

   ESPP
 
680

 
785

 
852

   Total
 
$
31,601

 
$
31,248

 
$
33,368
Schedule of the Company's stock option activity and related information
The following table summarizes the Company’s stock option activity and related information for the period from January 1, 2015 to December 31, 2017:
 
Number of
Options
 
Weighted
Average
Exercise Price (Per Share)
 
Weighted Average
Remaining
Contractual
Term (Years)
 
Aggregate
Intrinsic Value
(in Thousands)
Outstanding at December 31, 2014
4,677,856

 
$
35.78

 
7.86
 
$
248,276

Granted
906,706

 
75.35

 
 
 
 

Exercised
(618,434
)
 
16.29

 
 
 
$
39,401

Forfeited
(294,880
)
 
64.29

 
 
 
 

Expired
(25,526
)
 
81.94

 
 
 
 

Outstanding at December 31, 2015
4,645,722

 
44.03

 
7.31
 
$
162,340

Granted
1,656,598

 
38.20

 
 
 
 

Exercised
(518,226
)
 
11.13

 
 
 
$
21,750

Forfeited
(401,048
)
 
70.27

 
 
 
 

Expired
(175,303
)
 
80.91

 
 
 
 

Outstanding at December 31, 2016
5,207,743

 
42.16

 
7.39
 
$
37,581

Granted
1,072,625

 
43.93

 
 
 
 

Exercised
(539,989
)
 
12.55

 
 
 
$
15,865

Forfeited
(555,897
)
 
48.66

 
 
 
 

Expired
(232,989
)
 
74.65

 
 
 
 

Outstanding at December 31, 2017
4,951,493

 
$
43.51

 
6.91
 
$
57,021

Exercisable at December 31, 2017
2,882,384

 
$
42.20

 
5.51
 
$
47,082

Vested and expected to vest at December 31, 2017
4,951,493

 
$
43.51

 
6.91
 
$
57,021
Schedule of weighted average assumptions used to estimate the fair values of each option grant using the Black-Scholes option pricing model
The fair values of stock options granted were estimated using the Black-Scholes model with the following weighted average assumptions:
 
Year Ended December 31,
 
2017
 
2016
 
2015
Expected dividend yield
None
 
None
 
None
Risk-free interest rate
1.68% - 2.42%
 
1.03% - 2.48%
 
1.40% - 2.28%
Expected volatility
51.4%
 
53.5%
 
52.9%
Expected term of options
5.31 years
 
5.77 years
 
5.76 years