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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenues:      
Net product sales $ 284,342 $ 270,073 $ 244,487
Collaborative licensing and milestone revenue 387 3,426 1,426
Royalty revenue 1,901 2,872 3,084
Total revenues 286,630 276,371 248,997
Operating expenses:      
Cost of goods sold 87,915 110,104 71,837
Research and development 57,290 45,678 28,662
Selling, general and administrative 161,494 152,613 139,043
Product discontinuation 4,868 0 0
Total operating expenses 311,567 308,395 239,542
Income (loss) from operations (24,937) (32,024) 9,455
Other (expense) income:      
Interest income 4,078 1,323 678
Interest expense (18,047) (7,061) (7,725)
Loss on early extinguishment of debt (3,732)   (52)
Royalty interest obligation 0 0 (71)
Other, net 167 (82) (165)
Total other expense, net (17,534) (5,820) (7,335)
Income (loss) before income taxes (42,471) (37,844) 2,120
Income tax expense (140) (105) (264)
Net income (loss) $ (42,611) $ (37,949) $ 1,856
Net income (loss) per share:      
Basic net income (loss) per common share (in dollars per share) $ (1.07) $ (1.02) $ 0.05
Diluted net income (loss) per common share (in dollars per share) $ (1.07) $ (1.02) $ 0.04
Weighted average common shares outstanding:      
Basic (in shares) 39,806 37,236 36,540
Diluted (in shares) 39,806 37,236 41,301