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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Operating activities:    
Net income (loss) $ (8,116) $ (39,609)
Adjustments to reconcile net loss to net cash provided by operating activities:    
Depreciation of fixed assets 5,610 6,813
Amortization of unfavorable lease obligation and debt issuance costs 786 524
Amortization of debt discount 6,283 4,362
Loss on early extinguishment of debt 0 3,732
Loss on disposal of fixed assets 10 2,030
Stock-based compensation 15,432 14,744
Changes in operating assets and liabilities:    
Accounts receivable, net (3,640) 2,470
Inventories, net (642) (2,324)
Prepaid expenses and other assets 102 1,849
Increase (Decrease) in Accounts Payable (2,826) 2,149
Accrued expenses and income taxes payable (2,303) 8,402
Other liabilities 325 (1,480)
Net cash provided by operating activities 11,021 3,662
Investing activities:    
Purchases of fixed assets (7,818) (8,771)
Purchases of investments (182,749) (274,791)
Sales of investments 244,562 82,782
Payment of contingent consideration (4,715) (4,206)
Net cash provided by (used in) investing activities 49,280 (204,986)
Financing activities:    
Proceeds from exercise of stock options 1,492 2,613
Proceeds from Shares Issued Under Employee Stock Purchase Plans 952 1,056
Proceeds from 2022 convertible senior notes 0 345,000
Repayment of 2019 convertible senior notes 0 (118,191)
Payment of debt issuance and financing costs 0 (11,000)
Costs for conversions of convertible senior notes 0 (284)
Net cash provided by financing activities 2,444 219,194
Net increase in cash and cash equivalents 62,745 17,870
Cash and cash equivalents, beginning of period 54,126  
Cash and cash equivalents, end of period 116,871  
Supplemental cash flow information:    
Cash paid for interest 4,102 2,384
Income Taxes Paid, Net 146 133
Non-cash investing and financing activities:    
Issuance of common stock from conversion of 2019 convertible senior notes 0 120,960
Retirement of equity component of 2019 convertible senior notes 0 (126,326)
Net increase in accrued fixed assets $ 2,032 $ 2,294