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STOCK PLANS (Tables) | 12 Months Ended
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Dec. 31, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] |
Schedule of information about the plans | The following tables contain information about the Company’s stock incentive plans at December 31, 2018:
Stock Incentive Plan |  | Awards Reserved For Issuance |  | Awards Issued |  | Awards Available For Grant
2007 Plan |  | 2,022,837 |  |  | 2,022,837 |  |  | — |
2011 Plan |  | 9,931,700 |  |  | 8,392,572 |  |  | 1,539,128 |
2014 Inducement Plan |  | 175,000 |  |  | 36,576 |  |  | 138,424 |
|  | 12,129,537 |  |  | 10,451,985 |  |  | 1,677,552 |
Employee Stock Purchase Plan |  | Shares Reserved For Purchase |  | Shares Purchased |  | Shares Available For Purchase
2014 ESPP |  | 500,000 |  |  | 224,887 |  |  | 275,113 |
Schedule of recognized stock-based compensation in consolidated statements of operations | The Company recognized stock-based compensation expense in its consolidated statements of operations for the years ended December 31, 2018, 2017 and 2016 as follows (in thousands):
|  | Year Ended December 31,
|  | 2018 |  | 2017 |  | 2016
Cost of goods sold |  | $ | 4,478 |  |  | $ | 5,467 |  |  | $ | 6,438 |
Research and development |  | 3,934 |  |  | 3,341 |  |  | 3,297 |
Selling, general and administrative |  | 23,313 |  |  | 22,793 |  |  | 21,513 |
Total |  | $ | 31,725 |  |  | $ | 31,601 |  |  | $ | 31,248 |
Stock-based compensation from: |  |  |  |  |  |
Stock options (employee awards) |  | $ | 21,980 |  |  | $ | 24,056 |  |  | $ | 24,505 |
Stock options (consultant awards) |  | 663 |  |  | 167 |  |  | 841 |
RSUs |  | 8,371 |  |  | 6,698 |  |  | 5,117 |
ESPP |  | 711 |  |  | 680 |  |  | 785 |
Total |  | $ | 31,725 |  |  | $ | 31,601 |  |  | $ | 31,248 |
Schedule of the Company's stock option activity and related information | The following table summarizes the Company’s stock option activity and related information for the period from December 31, 2015 to December 31, 2018:
| Number of Options |  | Weighted Average Exercise Price (Per Share) |  | Weighted Average Remaining Contractual Term (Years) |  | Aggregate Intrinsic Value (in Thousands)
Outstanding at December 31, 2015 | 4,645,722 |  |  | $ | 44.03 |  |  | 7.31 |  | $ | 162,340 |
Granted | 1,656,598 |  |  | 38.20 |  |  |  |  |  |
Exercised | (518,226 | ) |  | 11.13 |  |  |  |  | $ | 21,750 |
Forfeited | (401,048 | ) |  | 70.27 |  |  |  |  |  |
Expired | (175,303 | ) |  | 80.91 |  |  |  |  |  |
Outstanding at December 31, 2016 | 5,207,743 |  |  | 42.16 |  |  | 7.39 |  | $ | 37,581 |
Granted | 1,072,625 |  |  | 43.93 |  |  |  |  |  |
Exercised | (539,989 | ) |  | 12.55 |  |  |  |  | $ | 15,865 |
Forfeited | (555,897 | ) |  | 48.66 |  |  |  |  |  |
Expired | (232,989 | ) |  | 74.65 |  |  |  |  |  |
Outstanding at December 31, 2017 | 4,951,493 |  |  | 43.51 |  |  | 6.91 |  | $ | 57,021 |
Granted | 1,994,332 |  |  | 39.35 |  |  |  |  |  |
Exercised | (332,732 | ) |  | 21.55 |  |  |  |  | $ | 7,418 |
Forfeited | (481,126 | ) |  | 42.30 |  |  |  |  |  |
Expired | (409,149 | ) |  | 68.01 |  |  |  |  |  |
Outstanding at December 31, 2018 | 5,722,818 |  |  | $ | 41.69 |  |  | 7.07 |  | $ | 49,166 |
Exercisable at December 31, 2018 | 3,009,133 |  |  | $ | 43.03 |  |  | 5.38 |  | $ | 37,629 |
Vested and expected to vest at December 31, 2018 | 5,722,818 |  |  | $ | 41.69 |  |  | 7.07 |  | $ | 49,166 |
Schedule of weighted average assumptions used to estimate the fair values of each option grant using the Black-Scholes option pricing model | The fair values of stock options granted were estimated using the Black-Scholes model with the following weighted average assumptions:
| Year Ended December 31,
| 2018 |  | 2017 |  | 2016
Expected dividend yield | None |  | None |  | None
Risk-free interest rate | 2.26% - 3.05% |  | 1.68% - 2.42% |  | 1.03% - 2.48%
Expected volatility | 53.3% |  | 51.4% |  | 53.5%
Expected term of options | 5.14 years |  | 5.31 years |  | 5.77 years
Schedule of Share-based Compensation, Restricted Stock Units Award Activity [Table Text Block] | The following table summarizes the Company’s RSU activity and related information for the period from December 31, 2015 to December 31, 2018:
| Number of Units |  | Weighted Average Grant Date Fair Value (Per Share) |  | Aggregate Intrinsic Value (in Thousands)
Unvested at December 31, 2015 | 216,198 |  |  | $ | 78.59 |  |  | $ | 16,602 |
Granted | 256,631 |  |  | 40.21 |  |  |  |
Vested | (61,487 | ) |  | 78.33 |  |  |
Forfeited | (46,939 | ) |  | 68.84 |  |  |  |
Unvested at December 31, 2016 | 364,403 |  |  | 52.85 |  |  | $ | 11,824 |
Granted | 343,583 |  |  | 44.23 |  |  |
Vested | (101,379 | ) |  | 53.76 |  |  |
Forfeited | (107,061 | ) |  | 49.98 |  |  |
Unvested at December 31, 2017 | 499,546 |  |  | 47.32 |  |  | $ | 22,804 |
Granted | 331,129 |  |  | 38.36 |  |  |
Vested | (156,450 | ) |  | 49.59 |  |  |
Forfeited | (96,261 | ) |  | 43.92 |  |  |
Unvested and expected to vest at December 31, 2018 | 577,964 |  |  | $ | 42.14 |  |  | $ | 24,864 |

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