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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Revenues:      
Net product sales $ 332,427 $ 284,342 $ 270,073
Collaborative licensing and milestone revenue 3,000 387 3,426
Royalty revenue 1,850 1,901 2,872
Total revenues 337,277 286,630 276,371
Operating expenses:      
Cost of goods sold 86,845 87,915 110,104
Research and development 55,688 57,290 45,678
Selling, general and administrative 177,265 161,494 152,613
Product discontinuation 1,564 4,868 0
Total operating expenses 321,362 311,567 308,395
Income (loss) from operations 15,915 (24,937) (32,024)
Other (expense) income:      
Interest income 6,497 4,078 1,323
Interest expense (21,949) (18,047) (7,061)
Loss on early extinguishment of debt 0 (3,732) 0
Other, net (888) 167 (82)
Total other expense, net (16,340) (17,534) (5,820)
Loss before income taxes (425) (42,471) (37,844)
Income tax expense (46) (140) (105)
Net loss $ (471) $ (42,611) $ (37,949)
Net loss per share:      
Basic and diluted net income (loss) per common share (in dollars per share) $ (0.01) $ (1.07) $ (1.02)
Weighted average common shares outstanding:      
Basic and diluted (in shares) 40,911 39,806 37,236