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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Operating activities:      
Net loss $ (471) $ (42,611) $ (37,949)
Adjustments to reconcile net loss to net cash provided by operating activities:      
Depreciation of fixed assets and amortization of intangibles 13,165 13,833 12,919
Amortization of unfavorable lease obligation and debt issuance costs 1,590 1,248 479
Amortization of debt discount 12,799 10,423 4,088
Loss on disposal of fixed assets 65 2,133 389
Loss on early extinguishment of debt 0 3,732 0
Stock-based compensation 31,725 31,601 31,248
Loss on unexercised investment purchase option 854 0 0
Changes in operating assets and liabilities:      
Accounts receivable, net (5,999) (1,721) (4,082)
Inventories, net (7,157) (10,133) 30,367
Prepaid expenses and other assets (3,228) 3,476 (3,377)
Accounts payable (573) 5,712 (350)
Accrued expenses and income taxes payable 5,203 3,647 1,060
Other liabilities 897 (3,555) (1,339)
Net cash provided by operating activities 48,870 17,785 33,453
Investing activities:      
Purchases of fixed assets (14,514) (19,266) (24,709)
Purchases of investments (363,255) (502,752) (192,815)
Sales of investments 405,188 321,713 171,627
Payment of contingent consideration (6,843) (8,460) (15,857)
Equity investment 0 (15,000) 0
Net cash provided by (used in) investing activities 20,576 (223,765) (61,754)
Financing activities:      
Proceeds from exercises of stock options 7,170 6,778 5,770
Proceeds from shares issued under employee stock purchase plan 1,784 1,862 1,495
Proceeds from issuance of 2022 convertible senior notes 0 345,000 0
Repayment of 2019 convertible senior notes   (118,193) (4)
Payment of debt issuance and financing costs 0 (11,000) 0
Costs for conversions of convertible senior notes 0 (285) 0
Net cash provided by financing activities 8,954 224,162 7,261
Net increase (decrease) in cash and cash equivalents 78,400 18,182 (21,040)
Cash and cash equivalents, beginning of year 54,126 35,944 56,984
Cash and cash equivalents, end of year 132,526 54,126 35,944
Supplemental cash flow information:      
Cash paid for interest 8,205 6,896 3,852
Cash paid for income taxes, net of refunds 128 129 247
Non-cash investing and financing activities:      
Issuance of common stock from conversion of 2019 convertible senior notes 0 120,960 0
Issuance of common stock from conversion of 2019 convertible senior notes 0 (126,328) 0
Net increase (decrease) in accrued fixed assets $ (98) $ 2,189 $ (789)