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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2021 | Sep. 30, 2020
Operating activities: |  |
Net income | $ 47,110 | $ 131,008
Adjustments to reconcile net income to net cash provided by operating activities: |  |
Deferred taxes | 12,953 | (124,572)
Depreciation of fixed assets and amortization of intangible assets | 15,478 | 14,847
Amortization of debt issuance costs | 1,976 | 1,512
Amortization of debt discount | 17,245 | 12,684
Loss on early extinguishment of debt | 0 | 8,071
(Gain) loss on disposal of fixed assets | (10) | 22
Stock-based compensation | 31,356 | 29,024
Changes in contingent consideration | (2,147) | (1,560)
Loss (gain) on investment and other non-operating income, net | 2,641 | (2,779)
Changes in operating assets and liabilities: |  |
Accounts receivable, net | 3,070 | 1,386
Inventories, net | (2,560) | (10,246)
Prepaid expenses and other assets | 907 | (382)
Accounts payable | (825) | (1,117)
Accrued expenses and income taxes payable | (17,034) | (16,454)
Other liabilities | (1,996) | (1,670)
Payment of contingent consideration to MyoScience, Inc. securityholders | (5,662) | (9,409)
Net cash provided by operating activities | 102,502 | 30,365
Investing activities: |  |
Purchases of fixed assets | (36,700) | (23,393)
Purchases of available-for-sale investments | (513,492) | (326,664)
Sales of available-for-sale investments | 470,614 | 154,767
Purchases of equity and debt investments | (17,187) | 0
Sale of equity investment | 9,057 | 0
Net cash (used in) investing activities | (87,708) | (195,290)
Financing activities: |  |
Proceeds from exercises of stock options | 19,049 | 35,980
Proceeds from shares issued under employee stock purchase plan | 1,574 | 1,421
Payment of debt issuance and financing costs | 0 | (12,487)
Payment of contingent consideration to MyoScience, Inc. securityholders | (1,338) | (5,591)
Net cash provided by financing activities | 19,285 | 211,941
Net increase in cash and cash equivalents | 34,079 | 47,016
Cash and cash equivalents, beginning of period | 99,957 | 78,228
Cash and cash equivalents, end of period | 134,036 | 125,244
Supplemental cash flow information: |  |
Cash paid for interest | 5,096 | 5,305
Cash paid for income taxes, net of refunds | 2,259 | 2,329
Non-cash investing and financing activities: |  |
Fixed assets included in accounts payable and accrued liabilities | 4,719 | 9,442
Convertible Senior Notes Due 2025 |  |
Financing activities: |  |
Proceeds from debt component of the 2025 convertible senior notes | 0 | 314,708
Proceeds from equity component of the 2025 convertible senior notes | 0 | 87,792
Convertible Senior Notes Due 2022 |  |
Financing activities: |  |
Repayments of convertible senior notes | 0 | (176,793)
Retirement of equity component of the 2022 convertible senior notes | $ 0 | $ (33,089)

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