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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Operating activities:    
Net income $ 47,110 $ 131,008
Adjustments to reconcile net income to net cash provided by operating activities:    
Deferred taxes 12,953 (124,572)
Depreciation of fixed assets and amortization of intangible assets 15,478 14,847
Amortization of debt issuance costs 1,976 1,512
Amortization of debt discount 17,245 12,684
Loss on early extinguishment of debt 0 8,071
(Gain) loss on disposal of fixed assets (10) 22
Stock-based compensation 31,356 29,024
Changes in contingent consideration (2,147) (1,560)
Loss (gain) on investment and other non-operating income, net 2,641 (2,779)
Changes in operating assets and liabilities:    
Accounts receivable, net 3,070 1,386
Inventories, net (2,560) (10,246)
Prepaid expenses and other assets 907 (382)
Accounts payable (825) (1,117)
Accrued expenses and income taxes payable (17,034) (16,454)
Other liabilities (1,996) (1,670)
Payment of contingent consideration to MyoScience, Inc. securityholders (5,662) (9,409)
Net cash provided by operating activities 102,502 30,365
Investing activities:    
Purchases of fixed assets (36,700) (23,393)
Purchases of available-for-sale investments (513,492) (326,664)
Sales of available-for-sale investments 470,614 154,767
Purchases of equity and debt investments (17,187) 0
Sale of equity investment 9,057 0
Net cash (used in) investing activities (87,708) (195,290)
Financing activities:    
Proceeds from exercises of stock options 19,049 35,980
Proceeds from shares issued under employee stock purchase plan 1,574 1,421
Payment of debt issuance and financing costs 0 (12,487)
Payment of contingent consideration to MyoScience, Inc. securityholders (1,338) (5,591)
Net cash provided by financing activities 19,285 211,941
Net increase in cash and cash equivalents 34,079 47,016
Cash and cash equivalents, beginning of period 99,957 78,228
Cash and cash equivalents, end of period 134,036 125,244
Supplemental cash flow information:    
Cash paid for interest 5,096 5,305
Cash paid for income taxes, net of refunds 2,259 2,329
Non-cash investing and financing activities:    
Fixed assets included in accounts payable and accrued liabilities 4,719 9,442
Convertible Senior Notes Due 2025    
Financing activities:    
Proceeds from debt component of the 2025 convertible senior notes 0 314,708
Proceeds from equity component of the 2025 convertible senior notes 0 87,792
Convertible Senior Notes Due 2022    
Financing activities:    
Repayments of convertible senior notes 0 (176,793)
Retirement of equity component of the 2022 convertible senior notes $ 0 $ (33,089)