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Condensed Consolidated Statements of Operations (USD $)
In Thousands, except Per Share data, unless otherwise specified
 3 Months Ended 6 Months Ended
Jun. 30, 2012
Jun. 30, 2011
Jun. 30, 2012
Jun. 30, 2011
Revenues:        
Collaboration revenue $ 1,623 $ 6,363 $ 2,552 $ 6,729
Grant revenue 882 890 1,969 1,779
Service and license revenue 179 16 513 505
Total revenues 2,684 7,269 5,034 9,013
Operating expenses:        
Research and development 11,376 13,257 23,781 27,929
General and administrative 5,957 4,054 11,750 8,808
Amortization of intangible assets   54   299
Total operating expenses 17,333 17,365 35,531 37,036
Loss from operations (14,649) (10,096) (30,497) (28,023)
Interest income 65 23 117 56
Interest expense (589) (487) (1,176) (977)
Other income (expense) 63 (75) (59) (157)
Net loss $ (15,110) $ (10,635) $ (31,615) $ (29,101)
Basic and diluted net loss per share $ (0.09) $ (0.09) $ (0.20) $ (0.25)
Shares used to compute basic and diluted net loss per share 167,697 117,864 161,564 116,801