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Condensed Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
 6 Months Ended
Jun. 30, 2012
Jun. 30, 2011
Operating activities    
Net loss $ (31,615) $ (29,101)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 592 704
Amortization of intangible assets   299
(Gain)/loss on disposal of assets   (8)
Non-cash interest associated with the note payable to Holdings 1,095 935
Fair value adjustment of the warrant and contingent liabilities to Holdings   17
Accretion of discounts and amortization of premiums of marketable securities 638 617
Stock-based compensation expense 4,391 2,647
Changes in operating assets and liabilities:    
Accounts receivable 8,243 (138)
Prepaid expenses and other current assets (3,015) (428)
Restricted cash and other assets (69) (178)
Accounts payable (885) (587)
Accrued liabilities and other long term liabilities (820) (3,188)
Deferred revenues (2,425) (715)
Net cash used in operating activities (23,870) (29,124)
Investing activities    
Purchases of marketable securities (114,400) (19,509)
Proceeds from maturities of marketable securities 70,085 34,367
Purchases of property and equipment, net (1,403) (419)
Net cash (used in) provided by investing activities (45,718) 14,439
Financing activities    
Proceeds from issuance of common stock, net of issuance costs 69,614 19,487
Proceeds from exercise of warrants 1,205 7
Proceeds from employee stock purchase plan 128 40
Proceeds from exercise of stock options 1,343 65
Net cash provided by financing activities 72,290 19,599
Effect of exchange rate on cash and cash equivalents (113) 112
Net decrease in cash and cash equivalents 2,589 5,026
Cash and cash equivalents at beginning of period 31,941 22,453
Cash and cash equivalents at end of period 34,530 27,479
Supplemental disclosure of cash flow information    
Disposal of fully depreciated property and equipment 19 845
Net change in unrealized gain on marketable securities $ (27) $ 19