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Condensed Consolidated Statements of Operations (USD $)
In Thousands, except Per Share data, unless otherwise specified
 3 Months Ended 9 Months Ended
Sep. 30, 2012
Sep. 30, 2011
Sep. 30, 2012
Sep. 30, 2011
Revenues:        
Collaboration revenue $ 1,050 $ 369 $ 3,602 $ 7,098
Grant revenue 1,219 658 3,188 2,437
Service and license revenue 605 147 1,118 652
Total revenues 2,874 1,174 7,908 10,187
Operating expenses:        
Research and development 12,850 11,777 36,631 39,706
General and administrative 7,121 4,217 18,871 13,025
Amortization of intangible assets       299
Total operating expenses 19,971 15,994 55,502 53,030
Loss from operations (17,097) (14,820) (47,594) (42,843)
Interest income 91 18 208 74
Interest expense (589) (485) (1,765) (1,462)
Other income (expense) (196) 58 (255) (99)
Net loss $ (17,791) $ (15,229) $ (49,406) $ (44,330)
Basic and diluted net loss per share $ (0.10) $ (0.12) $ (0.30) $ (0.37)
Shares used to compute basic and diluted net loss per share 177,870 124,069 167,039 119,244