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Condensed Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
 9 Months Ended
Sep. 30, 2012
Sep. 30, 2011
Operating activities    
Net loss $ (49,406) $ (44,330)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 898 1,009
Amortization of intangible assets   299
Loss (gain) on disposal of assets 6 (8)
Non-cash interest associated with the note payable to Holdings 1,642 1,403
Fair value adjustment of the warrant and contingent liabilities to Holdings   34
Accretion of discounts and amortization of premiums of marketable securities 970 895
Stock-based compensation expense 6,294 3,934
Changes in operating assets and liabilities:    
Accounts receivable 5,842 218
Prepaid expenses and other current assets (1,289) (33)
Restricted cash and other assets (74) (164)
Accounts payable (462) (1,016)
Accrued liabilities and other long term liabilities 1,011 (2,997)
Deferred revenues (1,649) (1,072)
Net cash used in operating activities (36,217) (41,828)
Investing activities    
Purchases of marketable securities (169,634) (38,007)
Proceeds from maturities of marketable securities 127,085 52,675
Purchases of property and equipment, net (1,727) (564)
Net cash (used in) provided by investing activities (44,276) 14,104
Financing activities    
Proceeds from offering of common stock, net of issuance costs 69,619 24,078
Proceeds from exercise of warrants 1,505 7
Proceeds from employee stock purchase plan 307 132
Proceeds from exercise of stock options 1,789 169
Net cash provided by financing activities 73,220 24,386
Effect of exchange rate on cash and cash equivalents (18) (43)
Net decrease in cash and cash equivalents (7,291) (3,381)
Cash and cash equivalents at beginning of period 31,941 22,453
Cash and cash equivalents at end of period 24,650 19,072
Supplemental disclosure of cash flow information    
Disposal of fully depreciated property and equipment 29 845
Net change in unrealized gain on marketable securities $ 32 $ 11