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Consolidated Statements Of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010
Revenues: |  |  |
Collaboration revenue | $ 4,610 | $ 17,190 | $ 19,535
Grant revenue | 3,939 | 3,110 | 3,940
Service and license revenue | 1,165 | 1,314 | 475
Total | 9,714 | 21,614 | 23,950
Operating expenses: |  |  |
Research and development | 49,146 | 51,322 | 53,680
General and administrative | 28,164 | 17,570 | 16,879
Amortization of intangible assets |  | 299 | 980
Total operating expenses | 77,310 | 69,191 | 71,539
Loss from operations | (67,596) | (47,577) | (47,589)
Interest income | 291 | 103 | 85
Interest expense | (2,351) | (1,957) | (1,654)
Other income (expense) | (293) | 834 | (8,150)
Net loss | $ (69,949) | $ (48,597) | $ (57,308)
Basic and diluted net loss per share | $ (0.41) | $ (0.39) | $ (0.69)
Shares used to compute basic and diluted net loss per share | 170,469 | 125,101 | 82,463

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