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Summary of Revenue Earned under Agreement with GSK (Detail) (USD $) In Thousands, unless otherwise specified | 3 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended
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Dec. 31, 2012 | Sep. 30, 2012 | Jun. 30, 2012 | Mar. 31, 2012 | Dec. 31, 2011 | Sep. 30, 2011 | Jun. 30, 2011 | Mar. 31, 2011 | Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010 | Dec. 31, 2012 National Institute Of Allergy And Infectious Diseases | Dec. 31, 2011 National Institute Of Allergy And Infectious Diseases | Dec. 31, 2010 National Institute Of Allergy And Infectious Diseases | Dec. 31, 2008 Glaxo, Smith, Kline | Dec. 31, 2012 Glaxo, Smith, Kline | Dec. 31, 2011 Glaxo, Smith, Kline | Dec. 31, 2010 Glaxo, Smith, Kline | Sep. 30, 2006 Astra Zeneca | Dec. 31, 2012 Astra Zeneca | Dec. 31, 2011 Astra Zeneca | Dec. 31, 2010 Astra Zeneca | Dec. 31, 2008 Astra Zeneca | Dec. 31, 2012 National Institutes of Health | Dec. 31, 2011 National Institutes of Health | Dec. 31, 2010 National Institutes of Health
Product Information [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Initial payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 10,000 | $ 1,428 | $ 1,428 | $ 1,428 | $ 10,000 | $ 720 | $ 120 | $ 10,778 |  |  |  |
Milestone revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 15,000 |  |  | 2,462 | 642 | 3,315 | 4,500 |  |  |
Total | 1,806 | 2,874 | 2,684 | 2,350 | 11,427 | 1,174 | 7,269 | 1,744 | 9,714 | 21,614 | 23,950 |  |  |  |  | 1,428 | 16,428 | 1,428 |  | 3,182 | 762 | 14,093 |  |  |  |
Grant revenue |  |  |  |  |  |  |  |  | $ 3,939 | $ 3,110 | $ 3,940 | $ 3,571 | $ 2,730 | $ 3,197 |  |  |  |  |  |  |  |  |  | $ 368 | $ 380 | $ 743

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- Definition Revenue earned during the period from non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.1(e)) -URI http://asc.fasb.org/extlink&oid=6880815&loc=d3e20235-122688 + Details
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- Definition The amount of consideration recognized during the period for the milestone or milestones. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 605 -SubTopic 28 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=19771982&loc=SL6892177-166501 + Details
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- Definition Aggregate revenue recognized during the period (derived from goods sold, services rendered, insurance premiums, or other activities that constitute an entity's earning process). For financial services companies, also includes investment and interest income, and sales and trading gains. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.1) -URI http://asc.fasb.org/extlink&oid=6880815&loc=d3e20235-122688 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 1 -Article 5 + Details
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