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Collaborative Research, Development, and License Agreements - Additional Information (Detail) (USD $) | 1 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended | 3 Months Ended |  |  |  |  |  | 1 Months Ended |  | 1 Months Ended
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Dec. 31, 2008 Glaxo, Smith, Kline Project | Dec. 31, 2012 Glaxo, Smith, Kline | Dec. 31, 2011 Glaxo, Smith, Kline | Dec. 31, 2010 Glaxo, Smith, Kline | Sep. 30, 2006 Astra Zeneca | Dec. 31, 2012 Astra Zeneca | Dec. 31, 2011 Astra Zeneca | Dec. 31, 2010 Astra Zeneca | Dec. 31, 2008 Astra Zeneca | Oct. 31, 2011 Astra Zeneca Amendment | Dec. 31, 2011 Astra Zeneca Amendment | Dec. 31, 2012 Astra Zeneca Amendment Advance the program following completion of Phase 2a | Mar. 31, 2012 Astra Zeneca Amendment Advance the program following completion of Phase 2a | May 31, 2012 National Institutes of Health Rheumatoid Arthiritis | Jun. 30, 2012 National Institutes of Health Autoimmune Disease | Jul. 31, 2011 National Institutes of Health Skin Autoimmune Inflammation | Aug. 31, 2010 National Institutes of Health HBV | Jul. 31, 2010 National Institutes of Health HPV | Sep. 30, 2008 National Institutes of Health ISS Technology | Jul. 31, 2008 National Institutes of Health SLE | Mar. 31, 2010 Merck HBV
Product Information [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of programs for research and early clinical development | 4 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration revenue | $ 10,000,000 | $ 1,428,000 | $ 1,428,000 | $ 1,428,000 | $ 10,000,000 | $ 720,000 | $ 120,000 | $ 10,778,000 |  | $ 3,000,000 |  | $ 6,000,000 | $ 2,600,000 |  |  |  |  |  |  |  | $ 4,000,000
Revenue from milestone payment |  |  | 15,000,000 |  |  | 2,462,000 | 642,000 | 3,315,000 | 4,500,000 |  |  | 20,000,000 |  |  |  |  |  |  |  |  |
Deferred revenue recognition period |  | 7 years |  |  |  | 50 months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue |  | 4,200,000 | 5,700,000 |  |  | 7,700,000 | 4,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research collaboration and license agreement period |  |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cost of clinical development activities |  |  |  |  |  |  |  |  |  |  | 20,000,000 |  |  |  |  |  |  |  |  |  |
Grants receivable |  |  |  |  |  |  |  |  |  |  |  |  |  | 400,000 | 600,000 | 600,000 | 1,100,000 | 600,000 |  | 1,800,000 |
Contract agreement period |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years |  |
Contract awarded to develop technology |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 17,000,000 |  |

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