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Consolidated Statements Of Cash Flows (USD $) In Thousands, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010
Operating activities |  |  |
Net loss | $ (69,949) | $ (48,597) | $ (57,308)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 1,207 | 1,303 | 1,415
Amortization of intangible assets |  | 299 | 980
Loss (gain) on disposal of property and equipment | 8 | 20 | (36)
Accretion of discounts and amortization of premiums of marketable securities | 1,298 | 1,172 | 367
Interest associated with long-term note payable to Holdings | 2,190 | 1,871 | 1,597
Fair value adjustment of the warrant and contingent liabilities to Holdings, including the impact of the anti-dilution provision associated with the common stock and warrants issued to Symphony Capital Partners, L.P. and Symphony Strategic Partners, LLC (collectively, "Symphony") |  | (843) | 8,816
Stock compensation expense | 10,439 | 5,189 | 2,410
Changes in operating assets and liabilities: |  |  |
Accounts receivable | 8,522 | (8,526) | (106)
Prepaid expenses and other current assets | (922) | 230 | (774)
Restricted cash and other assets | (116) | (290) | (38)
Accounts payable | 126 | (289) | 643
Accrued liabilities and other long term liabilities | 1,916 | (2,167) | 3,381
Deferred revenues | 1,472 | 3,512 | (12,717)
Net cash used in operating activities | (43,809) | (47,116) | (51,370)
Investing activities |  |  |
Purchases of marketable securities | (206,149) | (111,205) | (80,835)
Proceeds from maturities of marketable securities | 169,387 | 77,729 | 30,750
Purchases of property and equipment, net | (2,931) | (1,142) | (420)
Net cash used in investing activities | (39,693) | (34,618) | (50,505)
Financing activities |  |  |
Proceeds from issuances of common stock and warrants, net of issuance costs | 71,780 | 91,298 | 87,399
Proceeds from exercise of stock options and restricted stock awards | 1,955 | 10 | 160
Proceeds from employee stock purchase plan | 307 | 132 | 72
Payment of notes payable to Holdings | (15,000) |  |
Net cash provided by financing activities | 59,042 | 91,440 | 87,631
Effect of exchange rate on cash and cash equivalents | 118 | (218) | (23)
Net increase (decrease) in cash and cash equivalents | (24,342) | 9,488 | (14,267)
Cash and cash equivalents at beginning of year | 31,941 | 22,453 | 36,720
Cash and cash equivalents at end of year | 7,599 | 31,941 | 22,453
Non-cash investing and financing activities: |  |  |
Warrants issued in conjunction with the SDI transaction |  |  | 6,638
Disposal of fully depreciated property and equipment | 169 | 1,181 | 42
Net change in unrealized gain (loss) on marketable securities | 48 | 14 | (17)
Aspire Capital purchase agreement |  |  |
Non-cash investing and financing activities: |  |  |
Shares issued |  |  | 1,200
SDI transaction |  |  |
Non-cash investing and financing activities: |  |  |
Shares issued |  |  | $ 1,551

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