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Stockholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2012
Activity under Stock-Based Compensation Plans | Activity under our stock plans is set forth below:
|  | Shares Underlying Outstanding Options (in thousands) |  |  | Weighted-Average Exercise Price Per Share (in thousands) |  |  | Weighted-Average Remaining Contractual Term (years) |  |  | Aggregate Intrinsic Value |
Balance at December 31, 2011 |  |  | 10,987 |  |  | $ | 3.10 |  |  |  |  |  |  |  |  |
Options granted |  |  | 4,534 |  |  |  | 3.68 |  |  |  |  |  |  |  |  |
Options exercised |  |  | (1,166 | ) |  |  | 1.79 |  |  |  |  |  |  |  |  |
Options cancelled: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options forfeited (unvested) |  |  | (505 | ) |  |  | 3.32 |  |  |  |  |  |  |  |  |
Options cancelled (vested) |  |  | (44 | ) |  |  | 5.53 |  |  |  |  |  |  |  |  |
Balance at December 31, 2012 |  |  | 13,806 |  |  | $ | 3.38 |  |  |  | 7.26 |  |  | $ | 4,015 |
Vested and expected to vest at December 31, 2012 |  |  | 12,886 |  |  | $ | 3.37 |  |  |  | 7.13 |  |  | $ | 3,955 |
Exercisable at December 31, 2012 |  |  | 7,226 |  |  | $ | 3.49 |  |  |  | 5.91 |  |  | $ | 2,825 |
Summary of Restricted Stock Units Activity | A summary of the status of non-vested restricted stock units as of December 31, 2012, and activities during 2012 is summarized as follows:
|  | Number of Shares (In thousands) |  |  | Weighted-Average Grant-Date Fair Value |
Non-vested as of December 31, 2011 |  |  | 115 |  |  | $ | 1.98 |
Granted |  |  | 1,815 |  |  | $ | 4.23 |
Vested |  |  | (115 | ) |  | $ | 1.98 |
Forfeited or expired |  |  | (60 | ) |  | $ | 4.22 |
Non-vested as of December 31, 2012 |  |  | 1,755 |  |  | $ | 4.23 |
Black-Scholes Valuation Model and Weighted-Average Assumptions | The fair value of each option is estimated on the date of grant using the Black-Scholes option valuation model and the following weighted-average assumptions:
|  | Stock Options |  |  | Employee Stock Purchase Plan |
|  | Years Ended December 31, |  |  | Years Ended December 31, |
|  | 2012 |  |  | 2011 |  |  | 2010 |  |  | 2012 |  |  | 2011 |  |  | 2010 |
Weighted-average fair value |  | $ | 3.30 |  |  | $ | 2.76 |  |  | $ | 1.49 |  |  | $ | 3.53 |  |  | $ | 2.09 |  |  | $ | 1.47 |
Risk-free interest rate |  |  | 0.5 | % |  |  | 1.3 | % |  |  | 1.7 | % |  |  | 0.2 | % |  |  | 0.3 | % |  |  | 0.4 | %
Expected life (in years) |  |  | 4.2 |  |  |  | 4.0 |  |  |  | 4.0 |  |  |  | 1.1 |  |  |  | 1.2 |  |  |  | 0.9 |
Volatility |  |  | 1.6 |  |  |  | 1.6 |  |  |  | 1.6 |  |  |  | 1.6 |  |  |  | 1.6 |  |  |  | 1.6 |
Stock-Based Compensation Expense | We recognized the following amounts of stock-based compensation expense (in thousands):
|  | Years Ended December 31, |
|  | 2012 |  |  | 2011 |  |  | 2010 |
Employees and directors stock-based compensation expense |  | $ | 10,439 |  |  | $ | 5,185 |  |  | $ | 2,378 |
Non-employees stock-based compensation expense |  |  | — |  |  |  | 4 |  |  |  | 32 |
Total |  | $ | 10,439 |  |  | $ | 5,189 |  |  | $ | 2,410 |
|  | Years Ended December 31, |
|  | 2012 |  |  | 2011 |  |  | 2010 |
Research and development |  | $ | 3,514 |  |  | $ | 2,103 |  |  | $ | 632 |
General and administrative |  |  | 6,925 |  |  |  | 3,086 |  |  |  | 1,778 |
Total |  | $ | 10,439 |  |  | $ | 5,189 |  |  | $ | 2,410 |

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- Definition Tabular disclosure of the amount of total share-based compensation cost, including the amounts attributable to each share-based compensation plan and any related tax benefits. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of share-based compensation plans that may be presented in a single table for outstanding, vested and expected to vest, and exercisable awards. The information that may be disclosed in this table may include, but is not limited to, number of shares, weighted average exercise price, weighted average remaining contractual life, and aggregate intrinsic value. + References No definition available. + Details
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- Definition Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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