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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2012
Component of Consolidated Income (Loss) Before Provision for Income Taxes | Consolidated income (loss) before provision for income taxes consisted of the following (in thousands):
|  | Years Ended December 31, |
|  | 2012 |  |  | 2011 |  |  | 2010 |
U.S. |  | $ | (70,792 | ) |  | $ | (49,990 | ) |  | $ | (56,379 | )
Non U.S. |  |  | 843 |  |  |  | 1,393 |  |  |  | (929 | )
Total |  | $ | (69,949 | ) |  | $ | (48,597 | ) |  | $ | (57,308 | )
Difference Between Consolidated Income Tax Benefit and Amount Computed by Federal Statutory Income Tax Rate | The difference between the consolidated income tax benefit and the amount computed by applying the federal statutory income tax rate to the consolidated loss before income taxes was as follows (in thousands):
|  | Years Ended December 31, |
|  | 2012 |  |  | 2011 |  |  | 2010 |
Income tax benefit at federal statutory rate |  | $ | (23,650 | ) |  | $ | (16,523 | ) |  | $ | (19,486 | )
State tax |  |  | (89 | ) |  |  | (2,586 | ) |  |  | (1,617 | )
Tax credits |  |  | — |  |  |  | (1,394 | ) |  |  | (2,172 | )
Deferred compensation charges |  |  | 1,002 |  |  |  | 595 |  |  |  | 318 |
Change in valuation allowance |  |  | 21,966 |  |  |  | 18,099 |  |  |  | 19,863 |
Change in foreign tax rates |  |  | — |  |  |  | (34 | ) |  |  | 22 |
Change in the fair value measurements |  |  | — |  |  |  | 286 |  |  |  | 2,997 |
Non-deductible debt discount |  |  | — |  |  |  | 509 |  |  |  | 420 |
Deemed dividend |  |  | — |  |  |  | 273 |  |  |  | — |
Other |  |  | 771 |  |  |  | 775 |  |  |  | (345 | )
Total income tax expense |  | $ | — |  |  | $ | — |  |  | $ | — |
Component of Deferred Tax Assets and Liabilities | Deferred tax assets and liabilities as of December 31, 2012 and 2011 consisted of the following (in thousands):
|  | December 31, |
|  | 2012 |  |  | 2011 |
Deferred tax assets: |  |  |  |  |  |  |  |
Net operating loss carry forwards |  | $ | 127,529 |  |  | $ | 103,119 |
Research tax credit carry forwards |  |  | 18,163 |  |  |  | 17,477 |
Accruals and reserves |  |  | 8,529 |  |  |  | 6,818 |
Capitalized research costs |  |  | 12,757 |  |  |  | 17,278 |
Deferred revenue |  |  | 2,180 |  |  |  | 2,189 |
Other |  |  | 1,221 |  |  |  | 1,455 |
|  |  | 170,379 |  |  |  | 148,336 |
Less valuation allowance |  |  | (170,232 | ) |  |  | (148,266 | )
Total deferred tax assets |  |  | 147 |  |  |  | 70 |
Deferred tax liabilities: |  |  |  |  |  |  |  |
Acquired intangible assets |  |  | (86 | ) |  |  | (27 | )
Other |  |  | (61 | ) |  |  | (43 | )
Total deferred tax liabilities |  |  | (147 | ) |  |  | (70 | )
Net deferred tax assets |  | $ | — |  |  | $ | — |

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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32537-109319 + Details
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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32687-109319 + Details
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- Definition Tabular disclosure of income before income tax between domestic and foreign jurisdictions. + References No definition available. + Details
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