Income Taxes (Tables)

12 Months Ended

Dec. 31, 2012

Component of Consolidated Income (Loss) Before Provision for Income Taxes

Consolidated income (loss) before provision for income taxes consisted of the following (in thousands):


	Years Ended December 31,
	2012			2011			2010
U.S.	$	(70,792	)	$	(49,990	)	$	(56,379	)
Non U.S.		843			1,393			(929	)

Total	$	(69,949	)	$	(48,597	)	$	(57,308	)

Difference Between Consolidated Income Tax Benefit and Amount Computed by Federal Statutory Income Tax Rate

The difference between the consolidated income tax benefit and the amount computed by applying the federal statutory income tax rate to the consolidated loss before income taxes was as follows (in thousands):


	Years Ended December 31,
	2012			2011			2010
Income tax benefit at federal statutory rate	$	(23,650	)	$	(16,523	)	$	(19,486	)
State tax		(89	)		(2,586	)		(1,617	)
Tax credits		—			(1,394	)		(2,172	)
Deferred compensation charges		1,002			595			318
Change in valuation allowance		21,966			18,099			19,863
Change in foreign tax rates		—			(34	)		22
Change in the fair value measurements		—			286			2,997
Non-deductible debt discount		—			509			420
Deemed dividend		—			273			—
Other		771			775			(345	)

Total income tax expense	$	—		$	—		$	—

Component of Deferred Tax Assets and Liabilities

Deferred tax assets and liabilities as of December 31, 2012 and 2011 consisted of the following (in thousands):


	December 31,
	2012			2011
Deferred tax assets:
Net operating loss carry forwards	$	127,529		$	103,119
Research tax credit carry forwards		18,163			17,477
Accruals and reserves		8,529			6,818
Capitalized research costs		12,757			17,278
Deferred revenue		2,180			2,189
Other		1,221			1,455

		170,379			148,336
Less valuation allowance		(170,232	)		(148,266	)

Total deferred tax assets		147			70

Deferred tax liabilities:
Acquired intangible assets		(86	)		(27	)
Other		(61	)		(43	)

Total deferred tax liabilities		(147	)		(70	)

Net deferred tax assets	$	—		$	—