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Consolidated Statements Of Operations (USD $)
In Thousands, except Per Share data, unless otherwise specified
 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Revenues:      
Collaboration revenue $ 4,610 $ 17,190 $ 19,535
Grant revenue 3,939 3,110 3,940
Service and license revenue 1,165 1,314 475
Total 9,714 21,614 23,950
Operating expenses:      
Research and development 49,146 51,322 53,680
General and administrative 28,164 17,570 16,879
Amortization of intangible assets   299 980
Total operating expenses 77,310 69,191 71,539
Loss from operations (67,596) (47,577) (47,589)
Interest income 291 103 85
Interest expense (2,351) (1,957) (1,654)
Other income (expense) (293) 834 (8,150)
Net loss $ (69,949) $ (48,597) $ (57,308)
Basic and diluted net loss per share $ (0.41) $ (0.39) $ (0.69)
Shares used to compute basic and diluted net loss per share 170,469 125,101 82,463